A5008864873- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Mollusks and Parasites Studies
- Helminth infection and control
- Research on Leishmaniasis Studies
- Trace Elements in Health
- Medical and Biological Ozone Research
- Insect Resistance and Genetics
- Parasitic infections in humans and animals
- Vector-borne infectious diseases
- Parasitic Diseases Research and Treatment
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Environmental Crop Studies
- Nanoplatforms for cancer theranostics
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Insect symbiosis and bacterial influences
- Genetic diversity and population structure
- Macrophage Migration Inhibitory Factor
- Gut microbiota and health
- Bone Tissue Engineering Materials
- Insect Pest Control Strategies
Sun Yat-sen University
2016-2025
Hainan Medical University
2020-2025
Weifang People's Hospital
2025
Hainan General Hospital
2024-2025
Hospital for Tropical Diseases
2022
Fifth Affiliated Hospital of Sun Yat-sen University
2018-2021
Ministry of Education of the People's Republic of China
2010-2021
Guangdong Provincial Center for Disease Control and Prevention
2017-2020
Objectives: To assess the psychological status of college students in China during COVID-19 outbreak, and offer some theoretical evidence for intervention students. Methods: An online survey was conducted from May 10, 2020 to June 2020. Anxiety symptoms were measured by Generalized Disorder 7-Item Scale (GAD-7). Categorical data reported as number percentage, while continuous mean ± SD. Multivariate logistic regression models used evaluate association between different factors anxiety...
Objective: To examine the effects of coronavirus disease-2019 (COVID-19) exposure, expressive suppression/cognitive reappraisal, and demographic variables on post-traumatic stress symptoms (PTS) among Chinese.Methods: Participants were recruited by social media through WeChat 6 049 Chinese (aged from 17 to 63 years; median=24) 31 provinces included in study. PTS symptoms, suppression, cognitive reappraisal assessed after outbreak COVID-19. A regression mixture analysis was conducted Mplus...
Background: Epidemiologic studies and animal model experiments have shown that parasites significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of Schistosoma japonicum (S.japonicum) produced by Escherichia coli (E. coli), has been to immunoregulatory in vivo vitro. In this study, we aimed determine the rSj16 dextran sulfate sodium (DSS)-induced colitis. Methods: DSS-induced colitis mice were...
Schistosoma japonicum (S. japonicum) is one of the etiological agents schistosomiasis, a widespread zoonotic parasitic disease. However, mechanism balanced co-existence between host immune system and S. as well their complex interaction remains unclear. In this study, 16S rRNA gene sequencing combined with metagenomic approach, UPLC-MS metabolic profiling was applied to demonstrate changes in gut microbiome community structure during schistosomiasis progression, functional interactions...
Schistosomiasis japonicum remains a considerable economic and public health concern in China, the Philippines Indonesia. Currently available measures to control unique intermediate host Oncomelania hupensis are frequently associated with severe side effects. Previous studies have demonstrated that linalool-rich extracts from various plants exhibited promising biological activities including cytotoxic, anti-microbial anti-parasitic properties.We identified components of leaf Cinnamomum...
Ticks are small, blood-sucking arachnids, known vectors of various diseases, and found throughout the world. They distributed basically in almost all regions China. At present, there is not much information regarding tick species on Hainan Island. were subjected to morphological identification imaging an individual basis. Molecular phylogenetic analyses, based cox1 16S rRNA genes, utilized identify determine their approximate origin genetic diversity. The genomic DNA was extracted,...
Angiostrongylus cantonensis has been the only parasite among Angiostrongylidae to cause human central nervous system infection characterized by eosinophilic meningitis or meningoencephalitis. The mechanism of extensive neurological impairments hosts caused A. larvae remains unclear. aim present study was investigate apoptosis, necroptosis and autophagy in brains mice infected with cantonensis, which will be valuable for better understanding pathogenesis angiostrongyliasis cantonensis....
Schistosomiasis is a zoonotic and debilitating parasitic disease caused by Schistosoma japonicum. Praziquantel remains the choice for treating schistosomiasis, but its efficacy could be hampered emergence of resistance. In this study, using large-scale drug screening, we selected out myricetin, natural flavonol compound, having good anti-schistosome effect. We found that myricetin exhibited dose time-dependent insecticidal effect on S. japonicum in vitro, with an IC50 600 μM 24 h, inhibited...
Abstract Angiostrongylus cantonensis (AC) can cause severe eosinophilic meningitis or encephalitis in non-permissive hosts accompanied by apoptosis and necroptosis of brain cells. However, the explicit underlying molecular basis upon AC infection has not yet been elucidated. To determine specific pathways infection, gene set enrichment analysis (GSEA) protein–protein interaction (PPI) for expression microarray (accession number: GSE159486) mouse infected revealed that TNF-α likely played a...
Long-term infections by Clonorchis sinensis are associated with cholangitis, cholecystitis, liver fibrosis, cirrhosis, and even cancer. Molecules from the worm play vital roles in disease progress. In present study, we identified explored molecular characterization of C. granulin (CsGRN), a growth factor-like protein excretory/secretory products (CsESPs). The encoding sequence conserved domains CsGRN were analysed bioinformatics tools. Recombinant (rCsGRN) was expressed Escherichia coli BL21...
Triatoma rubrofasciata (T. rubrofasciata), one kind of triatomine insects, is the vector Trypanosoma cruzi cruzi), which lead to American trypanosomiasis. Although gut microbiome may play an essential role in development and susceptibility triatomine, there limited research on microbiota T. rubrofasciata. To elucidate effect vector's developmental stages environmental conditions microbiome, we employed 16S rRNA gene sequencing profile bacterial community diversity composition Significant...
Summary Sj16, a 16‐kDa protein produced by Schistosoma japonicum , has been demonstrated to have anti‐inflammatory effect. However, the possible mechanism of these phenomena not discovered. Here, we tried touch it with arthritis rats’ model induced injection complete Freund’s adjuvant (CFA). A set pathogenic characters were observed in CFA‐treated rat, including local and systematic read‐out, which showed successfully up. After administration rSj16 (recombinant Sj16) vivo paw swelling...
Schistosomiasis mansoni is one of the most important, but often neglected, tropical diseases transmitted by snails genus Biomphalaria. Control intermediate host snail plays a crucial role in preventing spread schistosomiasis. However, there only molluscicide, niclosamide, recommended World Health Organization. Niclosamide has been used for several decades toxic to non-target organisms. Therefore, it necessary optimize scaffold niclosamide and develop novel molluscicides with enhanced potency...