Background: The microbiota-gut-brain axis has been proposed as a potential therapeutic target of PD. effects curcumin against Parkinson's disease have demonstrated; however, its neuroprotective mechanisms remain unknown. Our study investigated the through which ameliorates via axis. Methods: Mice were randomly divided into four groups: control, Curcumin, MPTP, and MPTP + Curcumin. Motor deficits gastrointestinal dysfunction assessed using behavioral test, intestinal motility fecal parameter...

Parkinson's disease (PD) is the most prevalent movement disorder. Curcumin, a polyphenol with hydrophobic properties, has been proved against Parkinson. Our previous study suggested that curcumin's effectiveness in treating may be linked to gut-brain axis, although specific mechanism by which curcumin exerts neuroprotective effects brain remains unknown.

Parkinson's disease (PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction. The exploration of novel therapeutic strategies for PD is vital. To investigate the potential mechanism action rhapontin-a natural compound with known antioxidant anti-inflammatory properties-in context PD. Network pharmacology was used to predict targets mechanisms rhapontin in Behavioral tests tyrosine hydroxylase immunofluorescence analysis were assess effect on...

Parkinson's disease (PD) is a chronic progressive neurodegenerative commonly seen in aged people, which gastrointestinal dysfunction the most common nonmotor symptom and activation of gut-brain axis by intestinal inflammation may contribute to pathogenesis PD. In previous study, curcumin was considered neuroprotective PD, this mechanism act inhibiting inflammation. Therefore, aim study evaluate effect on motor loss dopaminergic neurons PD mouse model, induced...

Introduction . Recent studies suggest the involvement of ferroptosis in pathogenesis Parkinson disease (PD). δ ‐Opioid receptors (DORs) have neuroprotective effects PD. It is not known whether DORs PD are attributable to inhibition ferroptosis. Therefore, we aimed investigate role MPTP‐induced models. Methods To identify influence on models, measured malondialdehyde (MDA) and 4‐hydroxynonenal (4‐HNE) levels, analyzed levels ferroptosis‐related proteins (GXP4 SLC7a11) Nrf2 expression by using...

Observational studies have indicated an association between diabetes mellitus (DM), glycemic traits, and the occurrence of Parkinson's disease (PD). However, complex interactions these factors presence a causal relationship remain unclear. Therefore, we aim to systematically assess diabetes, PD onset, risk, progression. We used two-sample Mendelian randomization (MR) investigate potential associations PD. summary statistics from genome-wide (GWAS). In addition, employed multivariable...

To investigate the clinical phenotype-genotype correlations of a family with Kennedy disease (KD) and improve our understanding disease. KD was confirmed after phenotypic analyses, laboratory tests, polymerase chain reaction assays for cytosine-adenine-guanine (CAG) repeats, neuro-electrophysiological tests. The assessed using KD1234 scale spinal bulbar muscular atrophy functional rating scale. average age onset 30.8 ± 2.85 years. Clinically diagnosed members had 48 CAG repeats (≥35 is...

Objective To evaluate the clinical effect of acupuncture on Parkison disease (PD) with systematic review in view evidence-based medicine (EBM). Methods Articles Parkinson published from database-established year to May 2017 we searched China National Knowledge Internet (CNKI), Wanfang, VIP, Chinese Biomedical Literature Database (CBM), PubMed, and Cochrane Library databases without language limitation. Quality evaluation data extraction were carried out according tool for assessing...

Parkinson's disease (PD) is a common irreversible neurodegenerative associated with cognitive impairment. To investigate the serum level of phosphatidylinositol-3-kinase (PI3K) and distribution genotypes alleles 3 PI3K single-nucleotide polymorphisms (RS37,30,087, RS37,30,088, RS37,30,089) in PD patients different clinical characteristics. A total 54 50 healthy individuals were recruited. The was measured using enzyme-linked immunosorbent assay. severity assessed modified Hoehn-Yahr scale....

Parkinson′s disease is a neurodegenerative characterized by static tremor, myotonia, motor retardation and abnormal posture gait. Freezing of gait (FOG) common symptom advanced disease. At present, the pathogenesis frozen not clear, treatment still difficult. This article reviews latest progress in patients makes prospect. Key words: Parkinson disease; Freezing reaction, cataleptic; Gait disorders, neurologic; Review

Parkinson′s disease (PD) is a type of degenerative the nervous system. In addition to its typical clinical symptoms, non-motor symptoms mainly include sensory disorders, neuropsychiatric disorders and autonomic nerve which also have serious effects on patients. This article reviews performance, mechanism improve clinicians' attention quality life for Parkinson's patients. Key words: Parkinson disease; Sensation disorders; Mental disorders; Autonomic system diseases; Review

Parkinson's disease (PD) is a neurodegenerative characterized by degeneration and deletion of dopaminergic neurons in the substantia nigra pathological feature Louis body. The clinical manifestations including non motor symptoms symptoms. Cognitive impairment (CI) one most common patients with PD, Which includes mild cognitive (MCI) dementia. MCI an early manifestation dementia PD. Therefore, diagnosis treatment are very important for prognosis epidemiology, risk factors, heredity,...

Abstract Objective: By analyzing the clinical phenotype, genotype and family characteristics of a Kennedy disease family, to explore genetic further improve understanding disease. And through analysis phenotype draw pedigree diagram, provide counseling, in order block continued inheritance disease-causing genes. Methods: The research subjects were from discovered January 2019. For 5 clinically diagnosed patients including proband, Kennedy's function rating scale (KD1234) spinal cord bulbar...

Abstract Hypoxic/ischemic brain injury is a potential etiology of Parkinson’s disease (PD). There evidence suggesting that the up-regulation enkephalin, an endogenous opioid, in midbrain may have compensatory effect against (PD) related motor symptoms. To explore mechanism underlying this action, we investigated effects hypoxia and MPP + , pathological inducer PD, on δ-opioid receptor (DOR, enkephalin receptor), prohormone convertases 1 2 (PC1/PC2) in- vitro PD model PC12 cells. We found (1)...