A5088138942- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Statistical Methods and Inference
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Brain Metastases and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
- Statistical Methods and Bayesian Inference
- Antimicrobial Peptides and Activities
- Markov Chains and Monte Carlo Methods
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal Tumor Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Bayesian Methods and Mixture Models
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Zhejiang Cancer Hospital
2013-2025
North Sichuan Medical University
2023-2024
Nanchong Central Hospital
2019-2024
Qilu Hospital of Shandong University
2022-2024
The First People’s Hospital of Lianyungang
2024
The Fourth People's Hospital
2024
Nanjing Medical University
2024
Chinese Academy of Sciences
2022-2024
Chongqing Medical University
2020-2023
Significance One of the challenging problems in lung cancer is to understand how inflammation pathways influence on development and identify early immune mediators. In this study, we functionally dissect critical events occurring at interface between endogenously arising tumors host system that determine tumor progression. Our findings greatly advance our knowledge function T helper 17 cells help mechanisms inflammatory mediators promote cancer.
Abstract Activating mutations of K-ras are the most common oncogenic alterations found in lung cancer. Unfortunately, attempts to target K-ras–mutant tumors have thus far failed, clearly indicating need for new approaches patients with this molecular profile. We previously shown NF-κB activation, release IL6, and activation its responsive transcription factor STAT3 tumors, which was further amplified by tumor-enhancing effect chronic obstructive pulmonary disease (COPD)-type airway...
Safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) vs chemotherapy (nCT) for treatment locally advanced esophageal squamous cell carcinoma (ESCC) remain uncertain given lack high-level clinical evidence.To compare safety long-term survival nCRT followed by minimally invasive esophagectomy (MIE) with that nCT MIE patients ESCC.A prospective, multicenter, open-label, randomized trial compared ESCC. From January 1, 2017, to December 31, 2018, 264 ESCC stages from cT3 T4aN0 1M0 were...
•The CMISG1701 trial assessed the safety and efficacy of nCRT versus nCT followed by MIE for locally advanced bulky ESCC.•The strategy could not improve survival significantly compared with strategy.•The best neoadjuvant therapy ESCC remains a pending issue. BackgroundNeoadjuvant is recommended esophageal cancer, but optimal unclear. We aimed to evaluate chemoradiotherapy (nCRT) chemotherapy (nCT) minimally invasive esophagectomy (MIE) squamous cell carcinoma (ESCC).Patients methodsEligible...
Abstract Background Tumor cells produce various cytokines and chemokines that attract leukocytes. Leukocytes can amplify parenchymal innate immune responses, have been shown to contribute tumor promotion. Neutrophils are among the first arrive at sites of inflammation, increased number tumor-associated neutrophils is linked poorer outcome in patients with lung cancer. Results We previously COPD-like airway inflammation promotes cancer a K-ras mutant mouse model (CC-LR). This was associated...
Growing evidence indicates that systemic inflammation response and malnutrition status are correlated with survival in certain types of solid tumors. The aim this study is to evaluate the association between immune-inflammation index (SII) prognostic nutritional (PNI) overall (OS) patients esophageal squamous cell carcinoma (ESCC) after esophagectomy. A consecutive series 655 resected ESCC who underwent esophagectomy were enrolled retrospective study. preoperative SII was defined as platelet...
A current challenge for many Bayesian analyses is determining when to terminate high-dimensional Markov chain Monte Carlo simulations. To this end, we propose using an automated sequential stopping procedure that terminates the simulation computational uncertainty small relative posterior uncertainty. Further, show rule equivalent effective sample size sufficiently large. Such a has previously been shown work well in settings with posteriors of moderate dimension. In article, illustrate its...
Background The pathogenesis of post-stroke depression (PSD) remains largely unknown. There is growing evidence indicating that gut microbiota participates in the development brain diseases through gut-brain axis. Here, we aim to determine whether and how microbial composition function altered among control, stroke PSD rats. Materials Methods After rat model was successfully established, microbiome combined with fecal metabolome approach were performed identify potentially PSD-related...
The eyes and skin are obvious retinoid target organs. Vitamin A deficiency causes night blindness retinoids widely used to treat acne psoriasis. However, more than 90% of total body retinol is stored in liver stellate cells. In addition, hepatocytes produce the largest amount binding protein cellular retinoic acid mobilize from hepatic storage pool deliver its receptors, respectively. Furthermore, express highest x receptor alpha (RXRα) among all cell types. Surprisingly, function endogenous...
Purpose: Leptomeningeal metastasis (LM) is a detrimental complication of non-small cell lung cancer (NSCLC) and associated with poor prognosis. However, the underlying mechanisms process are still poorly understood.Experimental Design: We performed next-generation panel sequencing primary tumor tissue, cerebrospinal fluid (CSF), matched normal controls from epidermal growth factor receptor (EGFR) mutation-positive NSCLC patients LM.Results: The status EGFR-activating mutations was highly...
LBA329 Background: Neoadjuvant chemotherapy (nCT) or chemoradiotherapy (CRT) followed by surgery is the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). Despite significant advancements in therapeutic strategies, rate of recurrence remains high. Therefore, this multicenter, randomized, Phase III trial (SCIENCE) aims to evaluate and compare efficacy nCT nCRT plus Sintilimab, alone patients with LA-ESCC. Methods: Eligible thoracic ESCC had not...
ABSTRACT Background The recurrence patterns of different types pathologic regression the primary tumor and lymph nodes in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (NCRT) are little known, especially ypT0N+ patients. Methods We included 582 ESCC who had esophagectomy NCRT or radiotherapy (NRT) from 3 institutions. were divided into 4 groups: ypT0N0, ypT0N+, ypT+N0, ypT+N+ according to type pathological nodes. Survival, pattern timing,...
The problem of constructing Lyapunov functions for a class nonlinear dynamical systems is considered. reduced to the construction polytope satisfying some conditions. A generalization concept sector condition that it makes possible evaluate given function by using set piecewise-linear proposed. This improvement greatly reduces conservatism in stability analysis systems. Two algorithms such polytopes are proposed, and two examples shown demonstrate usefulness results.< <ETX...
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor. Tumor markers are very useful in early diagnosis; however single marker rather limited. We launched test to increase the diagnostic sensitivity through combined detection.Serum concentration of three tumor-markers, Glypican-3 (GPC-3), Human-Cervical-Cancer-Oncogene (HCCR) and a-fetoprotein (AFP), were determined 189 samples: 101 cases HCC, 40 cirrhosis, 18 hepatitis 30 control healthy donors. Every was evaluated for its value by...
Over-expressed in cancer cells, hexokinase II (HK II) forms a mitochondrial complex, which promotes survival. 3- Bromopyruvic acid (3-BrPA) dissociates HK from this causing cell death, and thus, having an anti-tumor effect. The design of study was to first analyze the expression hepatoma line, BEL-7402, then investigate effects 3-Br-PA on these finally, discuss its potential for clinical usage. detected BEL-7402 cells by immunocytochemistry reverse transcriptase polymerase chain reaction...