A5044106874- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Fire effects on ecosystems
- Power Systems and Renewable Energy
- Respiratory viral infections research
- Advanced SAR Imaging Techniques
- Influenza Virus Research Studies
- Smart Grid Energy Management
- Animal Disease Management and Epidemiology
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Viral gastroenteritis research and epidemiology
- Microgrid Control and Optimization
- Integrated Energy Systems Optimization
- Viral Infections and Immunology Research
- Electric Power System Optimization
- Animal Virus Infections Studies
- Electric Vehicles and Infrastructure
- SARS-CoV-2 and COVID-19 Research
- Radar Systems and Signal Processing
- Advanced Battery Technologies Research
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
Shandong Agricultural University
2022-2025
National University of Defense Technology
2013-2024
Jilin Electric Power Research Institute (China)
2018-2024
National Institute for Viral Disease Control and Prevention
2014-2023
Chinese Center For Disease Control and Prevention
2014-2023
Wuhan University of Science and Technology
2022-2023
Incept (United States)
2023
Princeton University
2023
Southwest Jiaotong University
2022
Chinese National Human Genome Center
2022
Abstract To investigate the infections of severe fever with thrombocytopenia syndrome virus (SFTSV) in domesticated animals, we sampled a total 3,039 animals 2 counties Shandong Province, People's Republic China, from April to November 2011. SFTSV-specific antibodies were detected 328 (69.5%) 472 sheep, 509 (60.5%) 842 cattle, 136 (37.9%) 359 dogs, 26 (3.1%) 839 pigs, and 250 (47.4%) 527 chickens. SFTSV RNA was all animal species, but prevalence low, ranging 1.7% 5.3%. A cohort study 38...
The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis SFTSV. We are unique in establishing infectious model C57/BL6 mice, resulting hallmark symptoms and leukocytopenia. Viral RNA histopathological changes were identified spleen, liver, kidney. However, replication was only found which suggested spleen be principle target organ Moreover, number macrophages platelets...
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by high fever, thrombocytopenia, multiorgan dysfunction, and a fatality rate between 12 30%. It caused SFTS virus (SFTSV), novel Phlebovirus in family Bunyaviridae . Although the viral pathogenesis remains largely unknown, hemopoietic cells appear to be targeted virus. In this study we report that human monocytes were susceptible SFTSV, which replicated efficiently, as shown...
Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses is a serious public health problem in China. The National Notifiable Disease Surveillance System (NNDSS) was established online China CDC 2004 and rodent surveillance sites were adjusted to 40 22 provinces 2005. Here we analyzed the data of both human cases rodents host during 2006-2012 examine epidemic trends HFRS recent years China.Records on from 2006 2012 analyzed. Phylogenetic tree based complete sequence M segment 58...
In this letter, a method is proposed to suppress the interrupted sampling repeater jamming (ISRJ) by jointly designing radar waveform and mismatch filter. The joint design problem under multiple constraints formulated with optimization criterion of minimizing integrated sidelobe levels (ISLs) filter output (ILs) ISRJ signal output. An iterative algorithm optimize using Lagrange multiplier alternating direction (ADMM), respectively. Simulation results demonstrate that achieves good pulse...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease and that a severe threat to public health considering its high fatality person-to-person transmission. In order obtain updated deep understanding of the epidemiological characteristics SFTS in mainland China, we used Pearson’s chi-squared test compare rate demographic different groups. Data were analyzed R3.6.1 (R Development Core Team 2018), while visualization was performed ArcGIS 10 (ESRI, Redlands, CA,...
The interrupted-sampling repeater jamming (ISRJ) is coherent and has the characteristic of suppression deception to degrade synthetic aperture radar (SAR) image quality. anti-ISRJ methods are studied in this work order suppress ISRJ based on waveform filter design for SAR. First, relationship between obtained by analyzing principle using ambiguity function. produces multiple false targets high Doppler tolerance matched filter. Next, a method proposed counter transmitting phase-coded (PC)...
Abstract Gene therapy is a new class of medical treatment that alters part patient’s genome through the replacement, deletion, or insertion genetic material. While still in its infancy, gene has demonstrated immense potential to treat and even cure previously intractable diseases. Nevertheless, existing prices are high, raising concerns about affordability for U.S. payers availability patients. We assess financial impact novel therapies by developing implementing an original simulation model...
THP-1 monocyte, which can be differentiated into macrophages by PMA, is widely used in researches on pathogen infection and host innate immunity, but reports the induction methods of PMA are different lack a unified standard, transcriptome characteristics macrophage compared with cells remains unclear. In this research, we examined differentiation effect three factors including time, cell seeding density concentration detecting positive rate CD14 expression. The 80ng/ml time 24h, 5×10 5...
Four cases of severe acute respiratory syndrome (SARS) that occurred from December 16, 2003, to January 8, 2004, in the city Guangzhou, Guangdong Province, China, were investigated. Clinical specimens collected these patients tested by provincial and national laboratories China as well members World Health Organization SARS Reference Verification Laboratory Network a collaborative effort identify confirm SARS-associated coronavirus (SARS-CoV) infection. Although SARS-CoV was not isolated any...
An outbreak of acute respiratory tract infection occurred in Shanxi Province, China, from March to April 2006. Of the 254 patients affected by this outbreak, 247 were students a senior high school; 1 these died during outbreak. Serological tests and blood culture revealed no evidence bacterial infection. The results direct reverse transcription-PCR or PCR performed with clinical specimens collected patients, including sole patient who died, positive for human adenoviruses (HAdVs) but...
ABSTRACT Cells are equipped with pattern recognition receptors (PRRs) such as the Toll-like and RIG-I-like that mount innate defenses against viruses. However, viruses have evolved multiple strategies to evade or thwart host antiviral responses. Viral inclusion bodies (IBs), which accumulated aggregates of viral proteins, commonly formed during replication some in infected cells, but their role immune evasion has rarely been explored. Severe fever thrombocytopenia syndrome (SFTS) is an...