A5101588949- HIV Research and Treatment
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Ocean Waves and Remote Sensing
- HIV/AIDS Research and Interventions
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Plant Virus Research Studies
- Wave and Wind Energy Systems
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Oceanographic and Atmospheric Processes
- HIV, TB, and STIs Epidemiology
- Fire effects on ecosystems
- Chemical Reactions and Isotopes
- Tuberculosis Research and Epidemiology
- Virus-based gene therapy research
- HIV, Drug Use, Sexual Risk
National Center for AIDS/STD Control and Prevention,China CDC
2017-2023
Kunming Medical University
2013-2015
Chinese Center For Disease Control and Prevention
2011-2014
National Institute for Viral Disease Control and Prevention
2011-2013
SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible SFTSV infection, but the infection nonhuman primates has not investigated. This study first report that, rhesus macaques, does cause symptoms or death fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases myocardial enzymes blood. Viremia, virus-specific...
Background SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding the antigen target humoral immune responses new bunyavirus infection. Methodology/Principal Findings We have generated combinatorial Fab antibody phage library from two patients recovered To date, 94 unique human antibodies been and characterized over 1200 clones obtained by screening purified...
Lung cancer is the leading cause of mortality and 5-year survival rate very low worldwide. Recent studies show that vascular endothelial growth factor receptor-3 (VEGFR-3) signaling pathway contributes to lung progression. So we hypothesize an oral DNA vaccine targets VEGFR-3 carried by attenuated Salmonella enterica serovar typhimurium strain SL3261 has impacts on In this study, VEGFR-3-based vaccine-immunized mice showed appreciable inhibition tumor lymphatic microvessels in model....
Human immunodeficiency virus 1 (HIV-1) attacks the immune system, making people susceptible to various diseases, thus increasing their risk of death. Comprehensive detection major HIV-1 strains circulating in China is vital for effective infection prevention and treatment. nucleic acid considered diagnosis since traditional immunological testing may fail detect during window period. This work demonstrates a one-pot two-stage amplification assay (RT-RAP), combination reverse transcription...
Objective: To compare the bio-equivalence among commercial HIV-1 viral load tests, including EasyQ v2.0 (EasyQ) from bioMerieux NucliSens of France; VERSANT RNA 3.0 assay (bDNA) Siemens Healthcare Diagnostics USA; COBAS AmpliPrep/COBAS TaqMan test (Taqman) Roche Molecular Diagnosis Abbott Real Time Kit (M2000) USA and two domestic kits (domestic kit) DaAn Gene Company Sun Yat-Sen University Liaoning Bio-Pharmaceutical company Northeast pharmaceutical group, by using proficiency results in...
Abstract Background Why some persons living with human immunodeficiency virus (HIV) (PLWH) progress quickly and others remain “healthy” for a decade or more without treatment remains fundamental question of HIV pathology. We aimed to assess the epidemiological characteristics long-term nonprogressors (LTNPs) based on cohort PLWH in China observed between 1989 2016. Methods conducted nationwide, retrospective study among Chinese diagnosed before 1 January 2008. Records were extracted from...
Abstract Severe Fever with Thrombocytopenia Syndrome (SFTS) emerged as an infectious disease in 2010 rural China, and its causative agent SFTS virus (SFTSV) is a new member of the family Bunyaviridae, genus phlebovirus, most closely related to heartland recently discovered Missouri, US. To develop effective vaccines therapeutics against this emerging pathogen, animal models are urgently needed. Here, we report first findings measurable clinical non-human primates infected SFTSV. In primate...
Objective: To analyze the longitudinal characteristics of CD4+T lymphocytes (CD4) among adult HIV/AIDS on antiretroviral therapy (ART) and related factors. Methods: A retrospective cohort starting ART in Dehong Dai Jingpo Autonomous Prefecture (Dehong) 2007-2016 was followed up to December 31, 2018. Group-based trajectory models were utilized identify CD4 subgroups based immune recovery (whether when reached average level >500 cells/μl). The demographics information at baseline described,...
Objective To study the factors that influence ex vivo proliferation of human immunodeficiency virus (HIV) specific CD8 T cells. Methods Three methods to use HIV-specific antigen peptides stimulating cells from HIV patients were compared, and effect adding exogenous IL-2 into co-culture on was evaluated. Results In comparison directly MHC I matched peripheral blood mononuclear (PBMCs) by presence during or incubating for 2 hours, more efficient stimulated loading mixed presenting...
Lung cancer is the leading cause of related deaths and need new more effective therapies. In this study, we investigated anti-tumor effect recombinant orally DNA vaccine delivered by attenuated S.typhimurium strain SL3261 (aroA mutant) targeting vascular endothelial growth factor receptor (VEGFR-2), also known as fetal liver kinase-1 (Flk-1) in mouse. The cDNA extracellular domains (ECD) VEGFR-2 (Flk-1ECD) was amplified RT-PCR cloned into pcDNA3.1 (+) vector, then transformed to construct...