A5003110957- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Virus-based gene therapy research
- COVID-19 Impact on Reproduction
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Vasculitis and related conditions
University of Hong Kong
2016-2025
Shantou University
2016-2025
East China Normal University
2025
Fujian Medical University
2025
Institute of Laboratory Animal Science
2013-2024
Zhejiang DongFang Vocational and Technical College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Hong Kong Science and Technology Parks Corporation
2022-2024
Laboratory of Data Discovery for Health
2022-2024
Shantou University Medical College
2013-2024
Summary We present an r package, ggtree , which provides programmable visualization and annotation of phylogenetic trees. can read more tree file formats than other softwares, including newick nexus NHX phylip jplace formats, support phylo, multiphylo, phylo4, phylo4d, obkdata phyloseq objects defined in packages. It also extract the tree/branch/node‐specific data from analysis outputs beast epa hyphy paml phylodog pplacer r8s raxml revbayes software, allows using these to annotate tree. The...
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This has been tentatively seafood market Wuhan, China, where sale wild animals may be source zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, identity any intermediate host that have facilitated transfer to humans unknown. Here we report identification SARS-CoV-2-related coronaviruses Malayan pangolins (Manis javanica) seized anti-smuggling...
Ggtree is a comprehensive R package for visualizing and annotating phylogenetic trees with associated data. It can also map visualize external data on phylogenies two general methods. Method 1 allows to be mapped the tree structure used as visual characteristic in visualization. 2 plots side by using different geometric functions after reordering based structure. These methods integrate phylogeny further exploration comparison evolutionary biology context. available from...
Phylogenetic trees and data are often stored in incompatible inconsistent formats. The outputs of software tools that contain with analysis findings not compatible each other, making it hard to integrate the results different analyses a comparative study. treeio package is designed connect phylogenetic tree input output. It supports extracting as well commonly used analytical software. can link external phylogenies merge obtained from sources, enabling phylogeny-associated disciplines an...
Coronaviruses in the Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute illness and kills about a third of people infected. The virus is common dromedary camels, which can be source human infections. In survey for MERSCoV over 1300 Saudi Arabian Sabir et al. found that dromedaries share three species with humans. Diverse MERS lineages camels have caused infections, suggests transfer among host occurs quite easily. Haagmans made MERS-CoV vaccine use using poxvirus as...
The emergence of pandemic H1N1/2009 influenza demonstrated that viruses could be generated in swine. Subsequent reintroduction to swine has occurred multiple countries. Through systematic surveillance from a Hong Kong abattoir, we characterize reassortant progeny with viruses. Swine experimentally infected this developed mild illness and transmitted infection contact animals. Continued reassortment produce variants transmissibility altered virulence for humans. Global is warranted.
Avian Flu in Ferrets A recent outbreak of avian H7N9 influenza humans eastern China has been closely monitored for any evidence human-to-human transmission and its potential sparking a pandemic. Zhu et al. (p. 183 , published online 23 May) examined the behavior virus ferret, mammalian model human influenza. The was excreted by ferrets could be transmitted readily contact but displayed limited capacity airborne infectivity. pathology is similar to H1N1, it seems that factors other than...
Abstract SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether how crosses blood–brain barrier (BBB). Herein, RNA was occasionally detected in vascular wall perivascular space, as well brain microvascular endothelial cells (BMECs) infected K18-hACE2 transgenic mice. Moreover, permeability vessel increased. Furthermore, disintegrity BBB discovered hamsters by administration Evans blue. Interestingly, expression...
The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis SFTSV. We are unique in establishing infectious model C57/BL6 mice, resulting hallmark symptoms and leukocytopenia. Viral RNA histopathological changes were identified spleen, liver, kidney. However, replication was only found which suggested spleen be principle target organ Moreover, number macrophages platelets...
A key observation about the human immune response to repeated exposure influenza is that first strain infecting an individual apparently produces strongest adaptive response. Although antibody titers measure response, interpretation of multiple strains – from same sera in terms infection history clouded by age effects, cross reactivity and waning. From July September 2009, we collected serum samples 151 residents Guangdong Province, China, 7 81 years age. Neutralization tests were performed...
Abstract The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, provisionally termed 2019-nCoV. This has been tentatively seafood market Wuhan, China, where the sale wild animals may be source zoonotic infection. Although bats are likely reservoir hosts for 2019-nCoV, identity any intermediate host facilitating transfer to humans unknown. Here, we report identification 2019-nCoV related coronaviruses pangolins ( Manis javanica ) seized...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, unique signature early responses remains elusive. We characterized transcriptome rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly induced in SARS-CoV-2-infected animal models as well COVID-19 patients. Paquinimod, a specific inhibitor S100A8/A9, could...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion remains elusive. Here, we show that classically activated M1 facilitate viral spread; however, alternatively M2 limit spread. utilize cellular softness efficiently take up SARS-CoV-2. Subsequently, invaded viruses over endo-lysosomal system escape. have a lower endosomal pH, favoring membrane fusion and allowing...
Remarkable progress has been made in developing intramuscular vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with respect to eliciting local immunity the tract, which is primary infection site for SARS-CoV-2. To overcome limitations of vaccines, we constructed a nasal vaccine candidate based on an influenza vector by inserting gene encoding receptor-binding domain (RBD) spike protein SARS-CoV-2, named CA4-dNS1-nCoV-RBD (dNS1-RBD). A...
The immunity of a host population against specific influenza A strains can influence number important biological processes, from the emergence new virus to effectiveness vaccination programmes. However, development an individual's long-lived antibody response over course lifetime remains poorly understood. Accurately describing this immunological process requires fundamental understanding how mechanisms boosting and cross-reactivity respond repeated infections. Establishing contribution such...
ABSTRACT A novel avian-origin influenza A/H7N9 virus emerged in 2013 to cause more than 130 cases of zoonotic human disease, with an overall case fatality rate around 30% detected. It has been shown that E-to-K amino acid change at residue 627 polymerase basic protein 2 (PB2) occurred frequently the H7N9 isolates obtained from humans but not viruses isolated poultry. Although this mutation reported confer increased mammalian pathogenicity other avian subtypes, it experimentally investigated...
<h3>Objective</h3> Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, humanised antibody that inhibits human IL-13, was evaluated for the treatment of <h3>Design</h3> In multicentre, randomised, double-blind, placebo-controlled study, patients with active UC (Mayo score ≥4 and <10) were randomised anrukinzumab 200, 400 or 600 mg placebo. Patients received five intravenous administrations over 14 weeks. The primary endpoint fold change from...
Recent studies have suggested that the etiology of autism spectrum disorder (ASD) may be caused by immunological factors, particularly abnormalities in innate immune system. However, it is still unclear which specific cytokines most importance. The current study therefore investigated showed altered concentrations blood ASD compared with healthy control children and were also correlated symptom severity. Our sample included 32 diagnosed 28 age sex-matched typically developing children....