A5085593848- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Microbial Community Ecology and Physiology
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Asthma and respiratory diseases
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neural Engineering
- Ion Transport and Channel Regulation
- Neural dynamics and brain function
- Genetic and Kidney Cyst Diseases
- Peroxisome Proliferator-Activated Receptors
- Spaceflight effects on biology
- Genomics and Phylogenetic Studies
- Neurogenesis and neuroplasticity mechanisms
- Marine Biology and Ecology Research
- Air Quality and Health Impacts
- Autophagy in Disease and Therapy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Alzheimer's disease research and treatments
- Nanomaterials for catalytic reactions
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2025
Institute of Laboratory Animal Science
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
1995-2025
Guangdong Pharmaceutical University
2023-2025
Peking Union Medical College Hospital
2012-2025
Chinese Institute for Brain Research
2014-2024
Peking University
2011-2024
Center for Life Sciences
2014-2024
Beijing University of Technology
2024
Institute of Oceanology
2022-2024
Abstract SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether how crosses blood–brain barrier (BBB). Herein, RNA was occasionally detected in vascular wall perivascular space, as well brain microvascular endothelial cells (BMECs) infected K18-hACE2 transgenic mice. Moreover, permeability vessel increased. Furthermore, disintegrity BBB discovered hamsters by administration Evans blue. Interestingly, expression...
Alzheimer's disease (AD) is a progressive neurodegenerative condition affecting around 50 million people worldwide. Bone marrow-derived mesenchymal stem cells (BMMSCs) have emerged as promising source for cellular therapy due to their ability differentiate into multiple cell types and paracrine effects. However, the direct injection of BMMSCs can lead potential unpredictable impairments, prompting renewed interest in effects AD treatment. The specific mechanism central role cytokines this...
Plant growth-promoting fungi (PGPF) have attracted considerable interest as bio-fertilisers due to their multiple beneficial effects on plant quantity and quality positive relationship with the ecological environment. Advancements in development of PGPF for crops economic cultivation applications been achieved, but such improvements use popular medicinal herbs, Salvia miltiorrhiza, are rare. In this study, we collected S. miltiorrhiza specimens inhabiting wild, semi-wild, farmland...
Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson's disease (PD). Many putative substrates parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization, particularly vivo. Here, we show that synaptotagmin-11, encoded by a PD-risk gene SYT11, is physiological substrate and plays critical roles mediating parkin-linked neurotoxicity. Unilateral overexpression full-length, but not C2B-truncated,...
A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying mechanism largely remains unknown. The major goal of present study was test role renal (pro)renin receptor (PRR) in this model. In Sprague-Dawley rats, intake increased expression full-length PRR, which were attenuated by allopurinol. High-fructose also upregulated mRNA and protein sodium/hydrogen exchanger 3 Na/K/2Cl cotransporter, as well vivo cotransporter activity, all nearly completely blocked a PRR...
Within the kidney, (pro)renin receptor (PRR) is predominantly expressed in collecting duct (CD), particularly intercalated cells, and it regulated by PGE 2 EP 4 . Notably, also controls urinary concentration through regulation of aquaporin (AQP2). Here, we tested hypothesis that sequential activation PRR determines AQP2 expression CD, thus mediating antidiuretic action vasopressin (AVP). Water deprivation (WD) elevated renal soluble excretion rats. Intrarenal infusion a decoy peptide, PRO20,...
(Pro)renin receptor (PRR) is predominantly expressed in the distal nephron where it activated by angiotensin II (ANG II), resulting increased renin activity renal medulla thereby amplifying de novo generation and action of local ANG II. The goal present study was to test role cycloxygenase-2 (COX-2) meditating II-induced PRR expression vitro vivo. Exposure primary rat inner medullary collecting duct cells induced sequential increases COX-2 protein expression. When were pretreated with a...
Significance With a combination of HPLC and carbon fiber electrodes, we demonstrate that grafted neural stem cells directly release dopamine in the damaged striatum vivo partially rescue Parkinson’s disease (PD) model. ( i ) Primitive cell–dopamine-like neuron (pNSC–DAn) retained tyrosine hydroxylase expression reduced PD-like asymmetric rotation; ii depolarization-evoked reuptake were significantly rescued vitro (brain slices) vivo, as determined jointly by microdialysis-based...
Abstract This study examines a specific channel of technology diffusion from multinational enterprises to domestic firms in less developed regions: research and development (R&D) activities the host country. Using firm‐level panel data Chinese science park, known as China's “Silicon Valley,” we find that R&D stock foreign‐owned has positive effect on productivity same industry, while capital foreign no such effect. These results suggest firms' knowledge spills over within industries...
Adriamycin (ADR) administration in susceptible rodents such as the BALB/c mouse strain produces injury to glomerulus mimicking human focal glomerular sclerosis. The goal of present study was use this model investigate antiproteinuric action nitro-oleic acid (OA-NO2), a nitric oxide-derived endogenous lipid product, which has exhibited multiple attractive signaling properties particularly kidney. mice were pretreated for 2 days with OA-NO2 at 5 mg·kg(-1)·day(-1) via an osmotic minipump,...
Key points The timing of synaptic transmission is critical to plasticity in the striatum. However, striatal dopamine (DA) release induced by cholinergic interneurons (ChIs) striatum unclear. In this study, we focused on temporal components DA and replenishment triggered different pathways. We show that stimulation ChIs induces with a total delay 20.6 ms, including 2.8 ms for action potential firing ChIs, 7.0 between acetylcholine terminals terminals, 10.8 downstream release. via ChI pathway...
Proteinuria is a characteristic of chronic kidney disease and also causative factor that promotes the progression, in part, via activation intrarenal renin-angiotensin system (RAS). (Pro)renin receptor (PRR), newly discovered component RAS, binds renin (pro)renin to promote angiotensin I generation. The present study was performed test role soluble PRR (sPRR) albumin overload-induced responses cultured human renal proximal tubular cell line 2 (HK-2) cells. Bovine serum albmuin (BSA)...
Neuropeptides released from dorsal root ganglion (DRG) neurons play essential roles in the neurotransmission of sensory inputs, including those underlying nociception and pathological pain. are intracellular vesicles through two modes: a partial release mode called "kiss-and-run" (KAR) full "full fusion-like" (FFL). Using total internal reflection fluorescence (TIRF) microscopy, we traced pH-sensitive green fluorescent protein-tagged neuropeptide Y (pHluorin-NPY) individual dense-core soma...
Removal of damaged and depolarized mitochondria, known as mitophagy, is critical to cellular homeostasis viability. Although initially identified in neurodegenerative diseases, mitophagy being recognized playing important roles during acute kidney injury. PINK1 Parkin play central regulating mitophagy. Here, we used knockout rats examine the role PINK1/Parkin-mediated cisplatin nephrotoxicity. Compared with wild-type rats, showed lower serum creatinine less tubular damage following...
Abstract Cold seep microbial communities are fascinating ecosystems on Earth which provide unique models for understanding the living strategies in deep-sea distinct environments. In this study, 23 metagenomes were generated from samples collected Site-F cold field South China Sea, including sea water closely above invertebrate communities, fluids, fluids under and sediment column around vent. By binning tools, we retrieved a total of 768 metagenome assembled genome (MAGs) that estimated to...
Coronavirus disease 2019 (COVID-19) is characterized by fever, fatigue, dry cough, dyspnea, mild pneumonia and acute lung injury (ALI), which can lead to respiratory distress syndrome (ARDS), SARS-CoV-2 accelerate tumor progression. However, the molecular mechanism for increased mortality in cancer patients infected with COVID-19 unclear. Colony formation wound healing assays were performed on Huh-7 cells cocultured syncytia. Exosomes purified from cell supernatant verified nanoparticle...
Fine particulate matter 2.5 (PM2.5) is a prevalent atmospheric pollutant that closely associated with asthma. Elderly patients have high incidence of asthma long course illness. Our previous studies revealed exposure to PM2.5 diminishes lung function and exacerbates damage in elderly rats. In the present study, we investigated whether influences susceptibility allergic Brown-Norway rats were treated ovalbumin (OVA) for different durations before after exposure. The results from pulmonary...
Regulatory T cells (Tregs) play critical roles in inhibiting antitumor immunity, which is dependent on FOXP3-mediated transcriptional activity. However, no Treg-specific therapeutics has been approved for clinical use. We performed a high-throughput screen of FDA-approved drugs potential inhibitors FOXP3 These efforts identified Lanatoside C (Lac), potently inhibits activity by causing degradation RUNX1, FOXP3-associated component required its Lac directly binds the E3 ligase STUB1, leading...
Space flight has many adverse effects on the physiological functions of astronauts. Certain similarities have been observed in some processes rodents and astronauts space, although there are also differences. These make helpful models for initial investigations into space-induced changes. This study uses a 3D-Clinostat to simulate microgravity explores role space flight-induced liver brain abnormalities by comparing changes gut microbiota, serum metabolites, function biochemistry tissues...