A5026607823- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Circular RNAs in diseases
- Advanced Fiber Laser Technologies
- HIV-related health complications and treatments
- RNA modifications and cancer
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Calcium signaling and nucleotide metabolism
- HIV Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Ion Channels and Receptors
- Advanced Fiber Optic Sensors
- Blood properties and coagulation
Xi'an Jiaotong University
2009-2025
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Southwest Medical University
2022-2025
Affiliated Hospital of Southwest Medical University
2024-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Chinese Institute for Brain Research
2013-2024
Peking University
2014-2024
Center for Life Sciences
2013-2024
Jining First People's Hospital
2018-2024
Macau University of Science and Technology
2024
Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like...
Abstract White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and formation new (adipogenesis). Adipogenesis results WAT hyperplasia, smaller a metabolically more favourable form obesity. How obesogenic hyperplasia is induced remains, however, poorly understood. Here, we show that the mechanosensitive cationic channel Piezo1 mediates diet-induced adipogenesis. Mice lacking mature demonstrated defective differentiation preadipocyte...
The extravasation of leukocytes is a critical step during inflammation that requires the localized opening endothelial barrier. This process initiated by close interaction with various adhesion molecules such as ICAM-1 on surface cells. Here we reveal mechanical forces generated leukocyte-induced clustering synergize fluid shear stress exerted flowing blood to increase plasma membrane tension and activate mechanosensitive cation channel PIEZO1. leads increases in [Ca2+]i activation...
Social memory has been developed in humans and other animals to recognize familiar conspecifics is essential for their survival reproduction. Here, we demonstrated that parvalbumin-positive neurons the sensory thalamic reticular nucleus (sTRN
Neurotransmitters and neuromodulators can be released via either action potential (AP)-evoked transient or AP-independent continuous neurotransmission. The elevated AP-evoked neurotransmission in the primary sensory neurons plays crucial roles hyperalgesia. However, whether how contributes to hyperalgesia remains largely unknown. Here, we show that dorsal root ganglion (DRG) exhibit frequent spontaneous microdomain Ca2+ (smCa) activities independent of APs across cell bodies axons, which are...
Astrocytes release a variety of signaling molecules including glutamate, d-serine, and ATP in regulated manner. Although the functions these molecules, from regulating synaptic transmission to controlling specific behavior, are well documented, identity their cellular compartment(s) is still unclear. Here we set out study vesicular exocytosis glutamate mouse hippocampal astrocytes. We found that small vesicles lysosomes coexisted same freshly isolated or cultured Both lysosome fused with...
Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson's disease (PD). Many putative substrates parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization, particularly vivo. Here, we show that synaptotagmin-11, encoded by a PD-risk gene SYT11, is physiological substrate and plays critical roles mediating parkin-linked neurotoxicity. Unilateral overexpression full-length, but not C2B-truncated,...
Purpose: Long noncoding RNA (lncRNA) deregulation is frequent in human ovarian cancers (OCs), but the role of specific miRNAs involved this disease remains elusive.LncRNA EMX2OS was previously reported to act as an oncogene cancers.However, their accurate expression, function and underlying mechanisms OC are largely unclear.Materials Methods: The levels tissues cell lines were determined by quantitative real-time PCR, then analyzed both vitro vivo.Luciferase assays immunoprecipitation...
Background: Vascular endothelial cells are critical for maintaining blood pressure (BP) by releasing biologically active molecules, such as nitric oxide. A non-endothelial cell resident matricellular protein, COMP (cartilage oligomeric matrix protein), plays a pivotal role in cardiovascular homeostasis, but little is known about its regulatory effect on BP. Methods: Mice were infused with AngII (angiotensin II; 450 ng/kg per minute) 3 days via an osmotic minipump, and BP was monitored...
Transient receptor potential A1 (TRPA1) is a nonselective cation channel implicated in thermosensation and inflammatory pain. In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) dorsal root ganglion (DRG) neurons presence absence of extracellular Ca2+. Pharmacological immunocytochemical analyses revealed channels both on plasma membrane endolysosomes. Confocal line-scan imaging demonstrated...
Significance With a combination of HPLC and carbon fiber electrodes, we demonstrate that grafted neural stem cells directly release dopamine in the damaged striatum vivo partially rescue Parkinson’s disease (PD) model. ( i ) Primitive cell–dopamine-like neuron (pNSC–DAn) retained tyrosine hydroxylase expression reduced PD-like asymmetric rotation; ii depolarization-evoked reuptake were significantly rescued vitro (brain slices) vivo, as determined jointly by microdialysis-based...
Animal models are crucial for elucidating the pathological mechanisms underlying Parkinson's disease (PD). Unfortunately, most of transgenic mouse fail to manifest changes observed in PD patients, pending advancement research. However, mechanism this discrepancy remains elusive. Here, we provide compelling evidence that compensatory expression synaptotagmin-11 (Syt11) plays a key role concealing PD-associated phenotypes parkin knockout (KO) models. Unlike normal dopamine (DA) release and...
Pathogenic microorganisms responsible for infectious diseases pose a significant global threat to human health. Existing detection methods, such as qPCR and ELISA, fail simultaneously meet the requirements high sensitivity, specificity, rapid detection. This study presents an innovative approach rapid, specific, highly sensitive of pathogenic microorganisms, particularly Escherichia coli O157:H7 (E. O157:H7) varicella-zoster virus (VZV), by combining recombinase polymerase amplification...
Key points The timing of synaptic transmission is critical to plasticity in the striatum. However, striatal dopamine (DA) release induced by cholinergic interneurons (ChIs) striatum unclear. In this study, we focused on temporal components DA and replenishment triggered different pathways. We show that stimulation ChIs induces with a total delay 20.6 ms, including 2.8 ms for action potential firing ChIs, 7.0 between acetylcholine terminals terminals, 10.8 downstream release. via ChI pathway...