A5005890921- Acute Ischemic Stroke Management
- Autoimmune and Inflammatory Disorders Research
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- RNA modifications and cancer
- Venous Thromboembolism Diagnosis and Management
- Parvovirus B19 Infection Studies
- Effects and risks of endocrine disrupting chemicals
- Adolescent and Pediatric Healthcare
- Botulinum Toxin and Related Neurological Disorders
- Systemic Lupus Erythematosus Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Family and Disability Support Research
- Inflammatory Biomarkers in Disease Prognosis
- Tuberculosis Research and Epidemiology
- Cancer-related gene regulation
- Toxic Organic Pollutants Impact
- Diabetic Foot Ulcer Assessment and Management
- Reproductive Biology and Fertility
- Psoriasis: Treatment and Pathogenesis
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disorders and Treatments
- Ureteral procedures and complications
Shanghai Jiao Tong University
2015-2025
Renji Hospital
2017-2025
Hunan Children's Hospital
2019-2024
Zhejiang University
2021-2024
Central South University
2024
North China University of Water Resources and Electric Power
2023
Academy of Social Sciences
2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Shandong Institute of Commerce & Technology
2022
Abstract Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for so-called ‘BPA-free’ plastics. Here we show that BHPF released from commercial bottles into drinking water and anti-oestrogenic effects mice. We demonstrate activity vitro and, an uterotrophic assay mice, induces low uterine weight, atrophic endometria causes adverse pregnancy outcomes, even at doses lower than...
The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. ER mitochondria form tight contacts at specific subdomains, which coordinate functions two organelles are required for multiple cellular processes such as Ca2+ transfer apoptosis. However, it largely unknown how morphology ER-mitochondria signaling dynamically regulated under different physiological or pathological conditions DNA damage. Here we show that peripheral,...
Significance Sex ratio is an important indicator of reproductive health, and its skewing reflects disturbed embryonic development. This study focused on sex skewing, which has recently identified in human vitro fertilization (IVF) babies. We reported herein that the skewed mouse IVF offspring was due to impaired imprinted X chromosome inactivation via suppressing ring finger protein 12 ( Rnf12 )/X-inactive specific transcript Xist ) pathway; can be corrected by overexpressing or...
The intracellular signaling mechanisms underlying postnatal angiogenesis are incompletely understood. Herein we show that Grb-2–associated binder 1 (Gab1) plays a critical role in ischemic and VEGF-induced angiogenesis. Endothelium-specific Gab1 KO (EGKO) mice displayed impaired the hindlimb despite normal induction of VEGF expression. Matrigel plugs with implanted EGKO induced fewer capillaries than those control mice. vessels endothelial cells (ECs) derived from were defective vascular...
Abstract The estrogenicity of parabens at human exposure levels has become a focus concern due to the debate over whether is strong enough play role in increased incidence breast cancer. In this study, uterotrophic activities methylparaben (MP) and ethylparaben (EP) doses close acceptable daily intake as allocated by JECFA were demonstrated immature Sprague-Dawley rats intragastric administration, up-regulations estrogen-responsive biomarker genes found uteri quantitative real-time RT–PCR...
Transient receptor potential A1 (TRPA1) is a nonselective cation channel implicated in thermosensation and inflammatory pain. In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) dorsal root ganglion (DRG) neurons presence absence of extracellular Ca2+. Pharmacological immunocytochemical analyses revealed channels both on plasma membrane endolysosomes. Confocal line-scan imaging demonstrated...
This study was designed to evaluate antiplatelet effect and therapeutic of ginkgo diterpene lactone meglumine injection (GDLI) in acute ischemic stroke (AIS) patients. In this randomized, double-blind, placebo-controlled trial, we randomly assigned 70 inpatients within 48 hr after the onset AIS combination therapy with GDLI aspirin (GDLI at a dose 25 mg/d for 14 days plus 100 90 days) or placebo ratio 1:1. Platelet function, National Institute Health Stroke Scale (NIHSS), modified Rankin...
Purpose: To investigate the risk factors associated with subclinical diabetic peripheral neuropathy (sDPN) in patients type 2 diabetes mellitus (T2DM). Patients and Methods: This cross-sectional, retrospective study involved 311 T2DM who were successively admitted from January 2018 to December 2021 without any neurological symptoms. All participants underwent a nerve conduction (NCS), those asymptomatic abnormal diagnosed sDPN. Differences between groups evaluated by chi-squared, Wilcoxon,...
Summary Objectives This study sought to evaluate the influence of genetic polymorphisms on platelet reactivity and clinical outcomes in acute ischemic stroke patients taking clopidogrel. Background Little research has been published relationships between polymorphisms, reactivity, treated with Methods Patients hospitalized Changhai Hospital were randomly enrolled into treatment a 75‐mg daily maintenance dose Genotyping was detected by Mass ARRAY iPLEX genotyping system (Sequenom Inc, San...
Leukocytes and fibrinogen are inflammatory markers involved in circulating central response after ischemic stroke. However, the interaction between leukocytes serum neuronal injury acute stroke (AIS) patients is still unclear. The present study aimed to investigate association leukocyte respectively AIS.A cross-section with 431 hospitalized AIS from department of neurology was performed. Circulating were measured, neuron-specific enolase (NSE) detected evaluate damage. A propensity score...
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a relatively rare and life-threatening disorder. Early mortality remains significantly high among patients with HLH. Our aim was to investigate clinical features risk factors associated 7-day 30-day pediatric HLH patients. We retrospectively collected medical records of discharge diagnosis between August 2014 October 2018 from tertiary children’s hospital in China. The main outcome measures were the after admission. associations...
Extracorporeal membrane oxygenation (ECMO) has been increasingly used as rescue therapy for severe pediatric acute respiratory distress syndrome (PARDS) over the past decade. However, a contemporary comparison of venovenous (VV) and venoarterial (VA) ECMO in PARDS yet to be well described. Therefore, objective our study was assess difference between VV VA efficacy safety infection-associated patients.This prospective multicenter cohort included patients with who received or intensive care...
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by excessive activation of the immune system, along with uncontrolled proliferation activated macrophages and lymphocytes. The clinical features HLH often overlap other severe inflammatory conditions such as sepsis, hindering accurate timely diagnosis. In this study, we performed data-independent acquisition mass spectrometry-based plasma proteomic analysis 33 pediatric patients...
Elevated red blood cell distribution width (RDW) has been found to be associated with the occurrence of ischemic stroke.However, there is no defined relationship between RDW and neuronal damage in acute stroke (AIS).This study was designed determine AIS patients.A total 442 consecutive patients from January 2018 June 2019 were evaluated for damage, which estimated by serum neuron-specific enolase (NSE) levels.Red width-standard deviation (RDW-SD), a parameter that reflects heterogeneity...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system. However, few biomarkers have been found to predict outcome immunotherapy. We investigated relationship between serum albumin (S-Alb) and response immunotherapy in acute NMOSD patients.