A5090388364- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Structural Behavior of Reinforced Concrete
- Chemical Synthesis and Analysis
- Structural Load-Bearing Analysis
- Structural Engineering and Vibration Analysis
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Click Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Innovative concrete reinforcement materials
- Fluorine in Organic Chemistry
- Cellular transport and secretion
- Vanadium and Halogenation Chemistry
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Advanced Nanomaterials in Catalysis
- Structural Analysis of Composite Materials
Fujian Normal University
2023-2025
Nanyang Technological University
2000-2023
Henan University of Technology
2023
Peking University
2011-2022
Health First
2020
East China Normal University
2015-2019
Astrocytes release a variety of signaling molecules including glutamate, d-serine, and ATP in regulated manner. Although the functions these molecules, from regulating synaptic transmission to controlling specific behavior, are well documented, identity their cellular compartment(s) is still unclear. Here we set out study vesicular exocytosis glutamate mouse hippocampal astrocytes. We found that small vesicles lysosomes coexisted same freshly isolated or cultured Both lysosome fused with...
Pd( ii )-catalyzed auto-tandem formal [4+1] cycloaddition of diazoacetates and aryl propargyl alcohols affords 2,5-dihydrofurans as the dominant product over traditional ones.
Nickel-catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive also works a 2-cyclopentenone ketal, which is equivalent to conjugate arylation the enone itself.
Palladium-catalyzed three-component carboetherification of cyclic alkenes proceeded to give trans adducts exclusively with excellent enantioselectivity through a Wacker-type pathway. The reaction is also applicable other oxygen nucleophiles, such as water, phenols, and carboxylic acids, well some electron-poor aryl amines.
Abstract Asymmetric coupling proceeds efficiently between propargylic acetates, cycloalkenes and electron‐rich heteroarenes including indoles, pyrroles, activated furans thiophenes. 2,3‐Disubstituted tetrahydrofurans pyrrolidines are produced in trans configuration excellent enantiomeric ratios. The reaction via Wacker‐type attack of nucleophilic on alkenes by allenyl Pd II species.
The palladium-catalyzed intermolecular Heck-type reaction of both cyclic and acyclic epoxides is reported with tolerance typical polar groups acidic protons. Suitable alkenes include styrenes, conjugate dienes, some electron-deficient olefins. In reactions aliphatic terminal epoxides, ring opening occurs selectively at positions, stereocenters are fully retained. Mechanistic studies provide evidence for in situ conversion to β-halohydrins, generation alkyl radicals, radical addition as key...
We report a green synthesis of spiro[2,3-dihydrofuran-3,3′-oxindole] derivatives which are potential value in medicinal chemistry.
Open AccessCCS ChemistryRESEARCH ARTICLES17 Jan 2025Constructing Intramolecular Electric Fields in NIR-II-Emissive Photosensitizers to Regulate the Local Electron Density for Boosting Hypoxia-Tolerant Cancer Phototheranostics Xiaoming Hu†, Cheng Zhang†, Jingqi Lv, Rongtian Li, Achen Qin, Caijun Zhu, Fengwei Sun, Zejing Chen, Shenghan Teng, Hongxin Lin, Zhen Yang and Wei Huang Hu† College of Photonic Electronic Engineering, Strait Institute Flexible Electronics (SIFE, Future Technologies),...
Amine-targeting reactions that work under biocompatible conditions or in water are green processes extremely useful for the synthesis of functional materials and biotherapeutics. Unfortunately, despite usefulness this reaction, there very few good amine-specific click methods reported thus far. Here, we report an reagent using alkynone β-trifluoroborates as electrophiles. These boron-containing alkynyl reagents exhibit high chemoselectivity toward amines even presence thiols. The resulting...
Site-specific modification of thiol-containing biomolecules has been recognized as a versatile and powerful strategy for probing our biological systems discovering novel therapeutics. The addition lipophilic silicon moiety opens up new avenues multi-disciplinary research with broad applications in both the medicinal material sciences. However, adhering to strict biocompatibility requirements, achieving introduction labile handle high chemo-selectivity have formidable. In this paper, we...
An NHC/chiral tertiary amine dual catalytic system for the aerobic oxidation/allylic amination reaction has been developed. The combination of NHC with organo-catalysts especially catalysts remains an underexplored area.
Nickel-catalyzed Heck reaction of cycloalkenes produces uncommon isomers with aryl rings in conjugation olefins.
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We report a bifunctional Ag catalyst promoted intramolecular capture of oxonium ylides with alkynes for the enantioselective synthesis 2,5-dihydrofurans.
This review summarizes recent advances in alkynyl trifluoroborate chemistry, emphasizing their unique reactivity and stability organic synthesis biological applications under transition metal catalyst-free conditions.
Abstract Palladium‐catalyzed three‐component carboetherification of cyclic alkenes proceeded to give trans adducts exclusively with excellent enantioselectivity through a Wacker‐type pathway. The reaction is also applicable other oxygen nucleophiles, such as water, phenols, and carboxylic acids, well some electron‐poor aryl amines.
Abstract Nickel‐catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive also works a 2‐cyclopentenone ketal, which is equivalent to conjugate arylation the enone itself.
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Keywords NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE, NEWCASTLE UNIVERSITY AUTOWAYS CONSTRUCTION KUALA, LUMPUR CONCRETE, BEAMS, DEEP, REINFORCED, PRESTRESSED, STRENGTH, SHEAR, DESIGN, METHODS, EQUATIONS, RESEARCH, CODES, BEHAVIOUR, WEBS, PRACTICE... Show All
Abstract Asymmetric coupling proceeds efficiently between propargylic acetates, cycloalkenes and electron‐rich heteroarenes including indoles, pyrroles, activated furans thiophenes. 2,3‐Disubstituted tetrahydrofurans pyrrolidines are produced in trans configuration excellent enantiomeric ratios. The reaction via Wacker‐type attack of nucleophilic on alkenes by allenyl Pd II species.
Here, we report a regio- and stereo-defined 1,3-heteroaryl acyloxylation of 3-substituted propargylic esters with readily available heteroarenes including indoles, pyrroles, furans thiophenes under palladium catalysis.