A5056939962- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Luminescence Properties of Advanced Materials
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Chemical Reactions and Isotopes
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Synthesis of Indole Derivatives
- Advanced Photocatalysis Techniques
- Organoselenium and organotellurium chemistry
- Chemical Synthesis and Reactions
- Radiation Detection and Scintillator Technologies
- Synthesis and Biological Evaluation
- Asymmetric Hydrogenation and Catalysis
- Microbial Natural Products and Biosynthesis
- Computational Drug Discovery Methods
- Photochromic and Fluorescence Chemistry
- Biochemical and Molecular Research
- Synthesis of Organic Compounds
- bioluminescence and chemiluminescence research
Kunming University of Science and Technology
2023-2025
Zhengzhou University
2012-2025
Materials Science & Engineering
2025
University of Arizona
2019-2024
University of New Mexico
2016-2017
Guangzhou University of Chinese Medicine
2016
Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins oligomerize into multiprotein complexes termed inflammasomes when activated. Their autoinhibition mechanism remains poorly defined. Here, we report the crystal structure of mouse NLRC4 in a closed form. The adenosine diphosphate-mediated interaction between central nucleotide-binding domain (NBD) winged-helix (WHD) was critical for stabilizing conformation NLRC4. helical HD2 repressively contacted conserved...
A solution to the unmet synthetic challenge of achieving highly atropo-enantioselective transesterification Bringmann's lactones has been realized, employing a chiral bifunctional amine thiourea as promoter. The synergistic activation and alcohols/phenols by respective groups is crucial for enantioselective, high-yielding dynamic kinetic resolution process. This protocol gives optically pure, axially biaryl compounds with broad substrate scope under mild reaction conditions.
Abstract Electrochemical converting CO 2 to via single atom catalyst is an effective strategy for reducing concentration in the atmosphere and achieving a carbon‐neutral cycle. However, relatively low industrial processes large energy barriers activating severely obstruct actual application. Reasonably modulating coordination shell of active center enhance activity catalysts. Herein, well‐designed single‐atom electrocatalyst Ni‐N 3 S 1 developed large‐scale synthesis strategy. The...
A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence potassium carbonate. The conditions this reaction also work well with crude acylhydrazone substrates obtained from condensation aldehydes hydrazides. series symmetrical asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) can be conveniently generated an efficient scalable fashion.
Abstract A simple formylation reaction of aryl halides, triflates, and vinyl bromides under synergistic nickel‐ organic‐dye‐mediated photoredox catalysis is reported. Distinct from widely used palladium‐catalyzed processes, this proceeds by a two‐step mechanistic sequence involving initial in situ generation the diethoxymethyl radical diethoxyacetic acid 4CzIPN‐mediated reaction. The formyl‐radical equivalent then undergoes nickel‐catalyzed substitution reactions with halides triflates to...
An approach for efficient synthesis of C-glycosyl amino acids is described. Different from typical photoredox-catalyzed reactions imines, the new process follows a pathway in which α-imino esters serve as electrophiles chemoselective addition with nucleophilic glycosyl radicals. The highlighted by mild nature reaction conditions, highly stereoselectivity attending C–C bond formation, and its applicability to C-glycosylations using both armed disarmed pentose hexose derivatives.
An unprecedented, chemo- and regioselective, organo-photoredox catalyzed hydroformylation reaction of aryl olefins with diethoxyacetic acid as the formylation reagent is described. In contrast to traditional transition metal promoted ionic reactions, new process follows a unique photoredox promoted, free radical pathway. this process, formyl equivalent, produced from diethoxacetic through dye (4CzIPN) photocatalyzed, sequential oxidation-decarboxylation route, regio- chemoselectively adds...
A mild, versatile organophotoredox protocol has been developed for the preparation of diverse, enantioenriched α-deuterated α-amino acids. Distinct from well-established two-electron transformations, this radical-based strategy offers unrivaled capacity convergent unification readily accessible feedstock carboxylic acids and a chiral methyleneoxazolidinone fragment simultaneous highly diastereo-, chemo-, regioselective incorporation deuterium. Furthermore, approach addressed long-standing...
H/D exchange at formyl groups represents the straightforward approach to C-1 deuterated aldehydes. This transformation has been recently realized by transition metal and NHC carbene catalysis. Mechanistically, all of these processes involve an ionic pathway. Herein, we report a distinct photoredox catalytic, visible light mediated neutral radical approach. Selective control highly reactive acyl in energy barrier surmountable, reversible reaction enables driving formation products when excess...
Abstract Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity engineered into α‐amino‐acid‐forming Petasis reaction occurring between aryl acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity process its ability generate structurally diverse valued aryl, heteroaryl, α,β‐unsaturated aldehydes containing wide array functional groups, demonstrates practical utility new synthetic strategy.
A mild organophotoredox synthetic protocol for forming a Csp3–S/Se bond by reacting widespread redox-active esters with thio/selenosulfonates has been developed. The power of the manifold is fueled an unprecedented broad substrate scope and wide functional group tolerance.
The dearomatization of indoles represents the most efficient approach for accessing highly valued indolines. inherent nucleophilic reactivity has dictated indole development in both 1e– and 2e– processes. However, electron-deficient been challenging. Herein, we introduce a conceptually distinct photoredox-mediated Giese-type transformation strategy, which is generally used conjugate addition radicals to simple α, β-unsaturated systems, chemoselectively breaking C═C bonds embedded aromatic...
Abstract A metal‐ and oxidant‐free catalytic method for accessing structurally diverse thioesters from readily accessible, widespread aldehydes, is described. strategy of a simple organic 9,10‐phenanthrenequinone‐promoted hydrogen atom transfer (HAT) with visible light was successfully implemented to selectively generate acyl radicals without inducing crossover reactivity thioester products. The preparative power the demonstrated by broad substrate scope wide functional group tolerance,...
Organophotoredox mediated HAT catalysis is developed for achieving high anomerically selective thioglycosylation of glycosyl bromides.
Accessing fascinating organic and biological significant indolines via dearomatization of indoles represents one the most efficient approaches. However, it has been difficult for electron deficient indoles. Here we report studies leading to developing a photoredox mediated Giese-type transformation strategy The reaction implemented chemoselectively breaking indolyl C=C bonds embedded in aromatic system. synthetic power this demonstrated by using structurally diverse bearing common...
A metal-free catalytic approach to tryptanthrins has been achieved for the first time. The unique process is realized by an organocatalytic and indole anthranilic acid substrate co-catalyzed photochemical oxidative condensation with visible light O2. truly environmentally friendly reaction conditions enable various reactants participate in deliver structurally diverse tryptanthrins.
Abstract A simple formylation reaction of aryl halides, triflates, and vinyl bromides under synergistic nickel‐ organic‐dye‐mediated photoredox catalysis is reported. Distinct from widely used palladium‐catalyzed processes, this proceeds by a two‐step mechanistic sequence involving initial in situ generation the diethoxymethyl radical diethoxyacetic acid 4CzIPN‐mediated reaction. The formyl‐radical equivalent then undergoes nickel‐catalyzed substitution reactions with halides triflates to...
Dearomatization has emerged as a powerful manifold for rapid construction of 3D molecular architectures from simple, abundant, and planar (hetero)arenes. The field evolved beyond the simple dearomatization driven by new synthetic technology development. With renaissance photocatalysis expanding activation mode, last few years have witnessed impressive developments on innovative photochemical methodologies, enabling skeletal modifications dearomatic structures. They offer truly efficient...
Abstract SrAl 2 O 4 :Eu 2+ , Dy 3+ (SAED) is one of the most popular materials for information storage and night display applications because it has a wide excitation range long afterglow duration. However improving hydrolytic resistance SAED remains challenge. In this study, presented to be ceramic type by solid‐state reaction in vacuum ambiance. The achieved 8200 mcd m −2 initial luminescence intensity. It can also obtain long‐persistent after UV light irradiation even soaking water more...