A5100359677- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- NF-κB Signaling Pathways
- Diverse Approaches in Healthcare and Education Studies
- Biological Research and Disease Studies
- Medicinal Plants and Bioactive Compounds
- Psoriasis: Treatment and Pathogenesis
- Renin-Angiotensin System Studies
- Atherosclerosis and Cardiovascular Diseases
- Biomedical Ethics and Regulation
- Protein Tyrosine Phosphatases
- Ginkgo biloba and Cashew Applications
- Complementary and Alternative Medicine Studies
- ATP Synthase and ATPases Research
- Chronic Kidney Disease and Diabetes
- Pain Management and Placebo Effect
- Histiocytic Disorders and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Respiratory and Cough-Related Research
- Mindfulness and Compassion Interventions
- Magnetism in coordination complexes
Southwest Medical University
2024
Liaocheng University
2024
Children's Hospital of Fudan University
2024
State Key Laboratory of Genetic Engineering
2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Shanghai Jiao Tong University
2016-2023
Shanghai Mental Health Center
2016-2023
Beijing University of Technology
2023
Dalian Medical University
2016-2021
Kunming Medical University
2021
Saikosaponins-a (Ssa) is a major bioactive extract of Radix Bupleuri which traditional Chinese medicine. The roles inflammatory response and lipid transportation in the process atherosclerosis have drawn increasing attention. We explored regulation immune-inflammatory role Ssa early atherosclerosis. antiatherogenic actions possible molecular mechanisms were texted THP-1 cells. examined effect on oxidized low-density lipoprotein (ox-LDL)-induced uptake, cholesterol efflux, response....
Background: Detection of retinal β-amyloid (Aβ) peptide accumulation is a novel diagnostic method for Alzheimer's disease (AD), but there is, as yet, no conclusive evidence its accuracy. Aim: To identify the accuracy pathological Aβ detection AD by meta-analytic approach. Methods: Electronic and reference searches were conducted to studies related effects in that met pre-defined inclusion criteria. The QUADAS-2 tool was employed assess risk bias, Review Manager plus Open Meta-Analyst used...
Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications in patients with diabetes. Accumulating evidence has demonstrated that DCM thoroughly related to mitochondrial energy impairment and increases generation reactive oxygen species (ROS). Therefore, an ongoing study developing strategies protect cardiac mitochondria from diabetic complications, especially hyperglycemia. Phosphocreatine (PCr) plays a major metabolic role muscular cells including intracellular...
Abstract Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found utero DBP exposure was associated with increase of adipose tissue weight serum lipids offspring, but the precise mechanism unknown. Here we aimed to study effects on obesity offspring examine possible mechanisms. SPF C57BL/6J pregnant mice were gavaged either (5 mg /kg/day) or corn oil, from gestational day 12 until 7. After...
Dynamic interpersonal therapy (DIT) is a brief, structured psychodynamic psychotherapy with demonstrated efficacy in treating major depressive disorder (MDD). The aim of the study was to determine whether DIT an acceptable and efficacious treatment for MDD patients China.Patients were randomized 16-week treatments either plus antidepressant medication (DIT + ADM; n = 66), general supportive (GST 75) or alone (ADM; 70). Hamilton Depression Rating Scale (HAMD) administered by blind raters...
Aim: A genomic region on 5q33.3 lies between and encompasses the IL12B PTTG1 genes, contains many potential psoriasis causal variants. We aimed to further examine influence of variants in around this region. Materials & methods: used least absolute shrinkage selection operator (LASSO)-based regression analysis assess independent contributions 2171 susceptibility tested them for association with different clinical subtypes. Results: found that ADRA1B gene contribute Chinese population. have a...
Soluble guanylatecyclase (sGC), as a NO receptor, is key metalloenzyme in mediating NO-signaling transduction. sGC activated by to catalyze the conversion of guanosine 5-triphosphate (GTP) cyclic guanylate monophosphate (cGMP). The dysfunction signaling results many pathological disorders, including several cardiovascular diseases such arterial hypertension, pulmonary heart failure and so on. Significant advances its structure, function, mechanism, physiological & roles have been made...
To reveal the molecular mechanism of antagonistic effect traditional Chinese medicine Tianma formula (TF) on dementia including vascular (VaD) and Alzheimer's disease (AD) to provide a scientific basis for study prevention treatment dementia.The TF was derived from concerted application medicine. We detected pharmacological in VaD rats. The examined by APP/PS1 mice vivo, Caenorhabditis elegans (C. elegans) vitro, ELISA, pathological assay via HE staining, transcriptome. Based RNA-seq...
Objective: To evaluate the potential hazards of organic pollutants in Jilin City Reach second Songhua River.Methods: water was concentrated and tested by vivo experiments on rats.Results : Testis organ coefficient decreased sperm deformity rate increased with increase OE dose each samples from low period high period.A significant decrease SOD activity a MDA content testis observed at 50mL/kg group midstream,25 mL/kg , 50 downstream period.Furthermore, reproductive toxicity extracts higher...
Sports events play an important role in modern society amid the prosperity of global economy and culture. However, holding mega sports produces greenhouse gas, which considerably contributes to warming. Although previous studies have contributed quantification carbon footprints, issue completeness uncertainties need be investigated further. Hence, this study proposes a model for quantifying life-cycle footprints large related them.First, quantitative footprint includes preparation stage, end...