A5077225971- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Genetic and phenotypic traits in livestock
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Genetics, Aging, and Longevity in Model Organisms
- Bipolar Disorder and Treatment
- Liver Disease Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Genetic Syndromes and Imprinting
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
Translational Genomics Research Institute
2016-2025
City Of Hope National Medical Center
2019-2025
City of Hope
2018-2025
Scripps Research Institute
2013-2024
University of California, San Diego
2015-2024
Fate Therapeutics (United States)
2023
Rady Children's Hospital-San Diego
2022
J. Craig Venter Institute
2014-2021
University College London
2021
Universidad Católica Santo Domingo
2021
High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined.To evaluate the effect of high-dose compared with standard-dose in patients high on-treatment PCI.Randomized, double-blind, active-control trial (Gauging Responsiveness A VerifyNow assay-Impact on Thrombosis And Safety [GRAVITAS]) 2214 12 24 hours PCI drug-eluting stents at 83 centers North...
Abstract Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common in children adolescents. However, standard histological criteria for pediatric NAFLD NASH undeveloped. We reviewed consecutive patients ages 2 to 18 years with biopsy-proven diagnosed between 1997 2003. Biopsies were evaluated by two pathologists individual features of steatohepatitis. Agglomerative hierarchical cluster analysis demonstrated different forms Type 1 was characterized steatosis,...
Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes methylation produce meiotically stable epialleles that transcription morphology, but rates spontaneous gain or loss are unknown. We examined spontaneously occurring variation Arabidopsis thaliana plants propagated by single-seed descent for 30 generations. identified 114,287 CG single polymorphisms 2485 differentially methylated regions (DMRs),...
N-of-1 or single subject clinical trials consider an individual patient as the sole unit of observation in a study investigating efficacy side-effect profiles different interventions. The ultimate goal n-of-1 trial is to determine optimal best intervention for using objective data-driven criteria. Such can leverage design and statistical techniques associated with standard population-based trials, including randomization, washout crossover periods, well placebo controls. Despite their...
Abstract Background Next generation sequencing (NGS) platforms are currently being utilized for targeted of candidate genes or genomic intervals to perform sequence-based association studies. To evaluate these this application, we analyzed human sequence generated by the Roche 454, Illumina GA, and ABI SOLiD technologies same 260 kb in four individuals. Results Local characteristics contribute systematic variability coverage (>100-fold difference per-base coverage), resulting patterns...
Natural epigenetic variation provides a source for the generation of phenotypic diversity, but to understand its contribution such interaction with genetic requires further investigation. Here we report population-wide DNA sequencing genomes, transcriptomes and methylomes wild Arabidopsis thaliana accessions. Single cytosine methylation polymorphisms are not linked genotype. However, rate linkage disequilibrium decay amongst differentially methylated regions targeted by RNA-directed is...
The use of direct-to-consumer genomewide profiling to assess disease risk is controversial, and little known about the effect this technology on consumers. We examined psychological, behavioral, clinical effects scanning with Navigenics Health Compass, a commercially available test uncertain validity utility.
Cross-sectional magnetic resonance imaging (MRI) studies have long hypothesized that the brain in children with autism undergoes an abnormal growth trajectory includes a period of early overgrowth; however, this has never been confirmed by longitudinal study. We performed first study toddlers at time symptoms are becoming clinically apparent using structural MRI scans multiple points beginning 1.5 years up to 5 age. collected 193 on 41 who received diagnosis autistic disorder ∼48 months age...
Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-based transcriptional artifacts, and can be applied archived frozen specimens. We used well-matched scRNA-seq datasets from mouse visual cortex compare type detection. Although more transcripts are detected in individual whole cells (~11,000 genes) than nuclei...