A5020851267- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Mental Health and Psychiatry
- Congenital heart defects research
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Child and Adolescent Health
- Electroconvulsive Therapy Studies
- Child Abuse and Trauma
- Infant Health and Development
- Functional Brain Connectivity Studies
- Early Childhood Education and Development
- Mental Health Treatment and Access
- Psychotherapy Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Psychopathy, Forensic Psychiatry, Sexual Offending
University of Washington
2015-2024
Seattle University
1996-2022
Washington State University Spokane
2018
American Academy of Child and Adolescent Psychiatry
2013-2015
Seattle Children's Hospital
1991-2010
University of Washington Medical Center
2010
University of Minnesota
2009
United States Department of State
2009
Washington Department of Social and Health Services
2009
National Institute of Mental Health
2007-2008
Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness. Microdeletions and microduplications >100 kilobases were identified by microarray comparative genomic hybridization of DNA from 150 individuals with schizophrenia 268 ancestry-matched controls. All validated high-resolution platforms. Novel deletions duplications genes present in 5% controls versus 15%...
Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances technologies detect these changes allow for routine identification of submicroscopic imbalances large numbers patients.
Objective: Atypical (second-generation) antipsychotics are considered standard treatment for children and adolescents with early-onset schizophrenia schizoaffective disorder. However, the superiority of second-generation over first-generation has not been demonstrated. This study compared efficacy safety two (olanzapine risperidone) a antipsychotic (molindone) in Method: double-blind multisite trial randomly assigned pediatric patients disorder to either olanzapine (2.5–20 mg/day),...
Africa, the ancestral home of all modern humans, is most informative continent for understanding human genome and its contribution to complex disease. To better understand genetics schizophrenia, we studied illness in Xhosa population South recruiting 909 cases 917 age-, gender-, residence-matched controls. Individuals with schizophrenia were significantly more likely than controls harbor private, severely damaging mutations genes that are critical synaptic function, including neural...
Background: In adolescents and adults, bipolar disorder (BD) is associated with significant morbidity, mortality, impairment in psychosocial occupational functioning. IPSRT an empirically supported adjunctive psychotherapy for adults disorder, which has been shown to help delay relapse, speed recovery from a depressive episode, increase functioning BD. This study designed describe the adolescent-specific developmental adaptations made (i.e., IPSRT-A) report results open trial of IPSRT-A 12...
Objective: This study examined racial and ethnic differences in treatment outcomes among participants a randomized controlled trial of an intervention for first-episode psychosis called NAVIGATE. Methods: Secondary data analyses were conducted randomly assigned to usual community care (N=181) NAVIGATE (N=223). Generalized estimating equations assessed whether race ethnicity associated with psychiatric symptoms service use (medication management, family psychoeducation, individual therapy)...
The primary aim of this study was to examine the effect recent tobacco, alcohol and cannabis use on treatment outcomes among participants experiencing first episode psychosis (FEP).Secondary data analyses were conducted 404 enrolled in Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study. RAISE-ETP investigated effectiveness a coordinated specialty care (CSC) intervention for FEP community mental health agencies United States. Generalized estimating...