Kristina A. Cole
A5005796905- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Gene expression and cancer classification
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Peroxisome Proliferator-Activated Receptors
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
University of Pennsylvania
2015-2025
Children's Hospital of Philadelphia
2016-2025
Cancer Research Institute
2012-2023
University of Chicago
2007-2022
University of Zurich
2022
Philadelphia University
2008-2022
University of Turku
2013
UNSW Sydney
2013
University of Helsinki
2013
Åbo Akademi University
2013
Using the URL at end of this item, readers can immediately offer feedback and suggestions on topic. A s list expressed human genes expands, a major scientific medical challenge is to understand molecular events that drive normal tissue morphogenesis progression
Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, number of cell-cycle proteins, particularly those within the Cyclin D/CDK4/CDK6/RB network, have been shown exert oncogenic roles in neuroblastoma, suggesting their therapeutic exploitation might improve patient outcomes.We evaluated effect dual CDK4/CDK6 inhibition on neuroblastoma viability using LEE011 (Novartis Oncology), highly specific CDK4/6 inhibitor.Treatment with significantly...
MicroRNAs are small noncoding RNAs that have critical roles in regulating a number of cellular functions through transcriptional silencing. They been implicated as oncogenes and tumor suppressor genes (oncomirs) several human neoplasms. We used an integrated genomics functional screening strategy to identify potential oncomirs the pediatric neoplasm neuroblastoma. first identified microRNAs map within chromosomal regions we others defined frequently deleted (1p36, 3p22, 11q23-24) or gained...
Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and often lethal. Its cause not known.
Neuroblastoma is a childhood cancer that often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when depleted, with loss cell cycle checkpoint kinase 1 (CHK1/CHEK1) being most potent. CHK1 mRNA expression was higher in MYC-Neuroblastoma-related (MYCN)-amplified (P < 0.0001) and high-risk = 0.03) tumors....
Abstract Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading (MMRD and PPD) in children harbour the highest mutational microsatellite insertion–deletion (MS-indel) burden humans. MMRD PPD cancers are commonly lethal due to inherent resistance chemo-irradiation. Although immune checkpoint inhibitors (ICIs) have failed benefit previous studies, we hypothesized that hypermutation caused by will improve outcomes following ICI treatment these patients. Using an...
Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.
Neuroblastoma is a malignant neoplasm of the developing sympathetic nervous system that notable for its phenotypic diversity. High-risk patients typically have widely disseminated disease at diagnosis and poor survival probability, but low-risk frequently localized tumors are almost always cured with little or no chemotherapy. Our genome-wide association study (GWAS) has identified common variants within FLJ22536, BARD1, LMO1 as significantly associated neuroblastoma more robustly high-risk...
Abstract Chromosome 6p22 was identified recently as a neuroblastoma susceptibility locus, but its mechanistic contributions to tumorigenesis are yet undefined. Here we report that the most highly significant single-nucleotide polymorphism (SNP) associations reside within CASC15, long noncoding RNA define tumor suppressor at 6p22. Low-level expression of short CASC15 isoform (CASC15-S) associated with advanced and poor patient survival. In human cells, attenuating CASC15-S increased cellular...
Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us examine downstream effectors this pathway and identify mitotic regulator Wee1 as an additional therapeutic target in disease. was overexpressed both neuroblastoma cell lines high-risk patient tumors. Genetic or pharmacologic abrogation signaling results marked cytotoxicity 10 11 with a median IC(50) 300 nmol/L for Wee1-selective small-molecule inhibitor MK-1775. Murine tumor...
Although replication repair deficiency, either by mismatch deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark MMRD alone. By genome-wide analysis tumors with germline and somatic deficiencies repair, we reveal novel association between proofreading MSI, especially when both components are lost. Analysis indels microsatellites (MS-indels) identified five distinct signatures (MS-sigs)....
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...