A5020138295- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- 3D Printing in Biomedical Research
- Molecular Biology Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Lanthanide and Transition Metal Complexes
- Neurobiology and Insect Physiology Research
- Medical Imaging Techniques and Applications
- Animal Behavior and Welfare Studies
- Photoreceptor and optogenetics research
- Atomic and Subatomic Physics Research
- Advanced Neural Network Applications
- Cancer Research and Treatments
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Advanced Fluorescence Microscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advanced Vision and Imaging
- Radiation Detection and Scintillator Technologies
- Cell Image Analysis Techniques
- Medical Imaging and Analysis
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
National Institute of Biomedical Imaging and Bioengineering
2007-2025
National Institutes of Health
2015-2024
Center for Information Technology
2012-2021
Signal Processing (United States)
2010-2021
Office of Extramural Research
2018
National Cancer Institute
1999-2011
Center for Cancer Research
2011
Science Applications International Corporation (United States)
2009
Using the URL at end of this item, readers can immediately offer feedback and suggestions on topic. A s list expressed human genes expands, a major scientific medical challenge is to understand molecular events that drive normal tissue morphogenesis progression
We determined the prostate cancer detection rate of multiparametric magnetic resonance imaging at 3T. Precise one-to-one histopathological correlation with was possible using based custom printed specimen molds after radical prostatectomy.This institutional review board approved prospective study included 45 patients (mean age 60.2 years, range 49 to 75) a mean specific antigen 6.37 ng/ml (range 2.3 23.7) who had biopsy proven Gleason score 6.7, 6 9). Before prostatectomy all underwent...
No AccessJournal of UrologyAdult Urology1 Oct 2012Correlation Magnetic Resonance Imaging Tumor Volume with Histopathology Baris Turkbey, Haresh Mani, Omer Aras, Ardeshir R. Rastinehad, Vijay Shah, Marcelino Bernardo, Thomas Pohida, Dagane Daar, Compton Benjamin, Yolanda L. McKinney, W. Marston Linehan, Bradford J. Wood, Maria Merino, Peter Choyke, and A. Pinto TurkbeyBaris Turkbey Molecular Program, National Cancer Institute, Bethesda, Maryland , ManiHaresh Mani Laboratory Pathology,...
Self-agency (SA) is the individual's perception that an action consequence of his/her own intention. The neural networks underlying SA are not well understood. We carried out a novel, ecologically valid, virtual-reality experiment using blood oxygen level-dependent functional magnetic resonance imaging (fMRI) where could be modulated in real-time while subjects performed voluntary finger movements. Behavioral testing was also to assess explicit judgment SA. Twenty healthy volunteers...
This work characterizes the uptake of <sup>11</sup>C-acetate in prostate cancer (PCa), benign hyperplasia, and normal tissue comparison with multiparametric MRI, whole-mount histopathology, clinical markers to evaluate potential utility for delineating intraprostatic tumors a population patients localized PCa. <b>Methods:</b> Thirty-nine men presumed PCa underwent dynamic–static abdominal–pelvic PET/CT 30 min 3-T MRI before prostatectomy. images were registered MR using pelvic bones initial...
Abstract We previously developed γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that enzyme γ-glutamyltranspeptidase (GGT) is overexpressed membranes of various but not expressed in normal tissue. Cleavage probe by GGT generates fluorescence. Here, we examined feasibility clinical application gGlu-HMRG during breast-conserving surgery. found fluorescence derived from cleavage allowed easy discrimination breast tumors, even...
A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images order to facilitate process correlating with histopathology is presented. The applied radical prostatectomy specimens where customized mold designed using magnetic resonance (MR) each obtained prior surgery. In this case, holds prostate place while knife single blade or multiple blades inserted slots which are positioned obtain blocks corresponding slices MR images. resulting...
Purpose: There is a growing need to localize prostate cancers on magnetic resonance imaging (MRI) facilitate the use of image guided biopsy, focal therapy, and active surveillance follow up. Our goal was develop decision support system (DSS) for detecting localizing peripheral zone by using machine learning approach calculate cancer probability map from multiparametric MR images (MP-MRI). Methods: This IRB approved Health Insurance Portability Accountability Act compliant retrospective study...
The receptor mechanism for color vision has been extensively studied. In contrast, the circuit(s) that transform(s) photoreceptor signals into percepts to guide behavior remain(s) poorly characterized. Using intersectional genetics inactivate identified subsets of neurons, we have uncovered first-order interneurons are functionally required hue discrimination in Drosophila. We developed a novel aversive operant conditioning assay intensity-independent (true vision) Single flying flies...
Laser capture microdissection (LCM) is a new method used to select and procure cell clusters from tissue sections. Once captured, the DNA, RNA or protein can be easily extracted isolated cells analyzed by conventional PCR, reverse transcription (RT)-PCR polyacrylamide gel electrophoresis, including zymography for specific macromolecular changes. In LCM, thermoplastic polymer coating [ethylene vinyl acetate (EVA)] attached rigid support placed in contact with section. The EVA over...
Abstract Three-dimensional (3D) in vitro cell culture models are invaluable tools for investigating the tumor microenvironment (TME). However, analyzing impact of critical stromal elements, such as extracellular matrix (ECM), remains a challenge. Here, we developed hydrogel-free self-assembly platform to establish ECM-rich 3D “MatriSpheres” deconvolute cancer cell-ECM interactions. Mouse and human colorectal (CRC) MatriSpheres actively incorporated microgram quantities decellularized small...
The application of direct time-locked subsampling (TLSS) to Fourier transform electron paramagnetic resonance (FT-EPR) spectroscopy at radio frequencies (rf) is described. With conventional FT-EPR spectroscopy, the high Larmor (Lf) often necessitate use intermediate frequency (IF) stages down convert received free induction decay (FID) signal a that can be acquired with common data acquisition technology. However, our research focuses on in vivo studies, and consequently utilizes system Lf...
Abstract Video monitoring of mice in the home-cage reveals behavior profiles without disruptions caused by specialized test setups and makes it possible to quantify changes patterns continually over long time frames. Several commercial systems are available with varying costs capabilities; however there currently no open-source for monitoring. We present an system top-down video research a slightly modified home-cage. The is designed integration Allentown NexGen ventilated racks allows...
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Authors...
Analytical ultracentrifugation (AUC) is a classical technique of physical biochemistry providing information on size, shape, and interactions macromolecules from the analysis their migration in centrifugal fields while free solution. A key mechanical element AUC centerpiece, component sample cell assembly that mounted between optical windows to allow imaging seal solution column against high vacuum exposed gravitational forces excess 300,000 g. For sedimentation velocity it needs be...
Sentinel lymph node biopsy is performed as a standard procedure in breast cancer surgery, and the development of quick simple methods to detect metastatic lesions high demand. Here, we validated new fluorescent method using γ-glutamyl hydroxymethyl rhodamine green diagnose nodes cancer. One hundred forty-nine from 38 patients were evaluated this study. Comparison pathological images showed that was successful for visualizing cells nodes. This had sufficiently sensitivity (97%), specificity...