Michael T. McCurdy
A5075777842- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Disaster Response and Management
- Intensive Care Unit Cognitive Disorders
- Renal function and acid-base balance
- Trauma and Emergency Care Studies
- Mechanical Circulatory Support Devices
- Radiology practices and education
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Radiation Dose and Imaging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Global Health and Surgery
- Trauma Management and Diagnosis
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Failure Treatment and Management
University of Maryland, Baltimore
2016-2025
St. Joseph Medical Center
2021-2024
Thomas Jefferson University Hospital
2023-2024
Rothman Orthopaedics
2023-2024
Institute of Semitic Studies
2024
Rothman Institute
2023-2024
Thomas Jefferson University
2023-2024
Pulmonary and Critical Care Associates
2021-2023
Boston Biomedical (United States)
2022-2023
University of British Columbia
2023
Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for treatment patients this condition.We randomly assigned vasodilatory who were receiving more than 0.2 μg norepinephrine per kilogram body weight minute or equivalent dose another vasopressor receive infusions either placebo. The primary end point was a response respect mean arterial pressure at hour 3 after start infusion, defined as an...
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema macules—the involvement the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated analyzed two single-cell RNA sequencing datasets human minor salivary glands gingiva (9 samples, 13,824 cells), identifying 50 cell clusters. Using integrated normalization annotation, classified 34 unique subpopulations between gingiva. Severe acute...
BACKGROUND: Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use reduced of mechanical ventilation, intensive care unit (ICU) admission, in-hospital mortality. METHODS: A retrospective, observational cohort study adult patients admitted COVID-19 to multiple hospitals the United States between March 2020 July was performed. The primary outcome need for...
Abstract Background Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence the respiratory management COVID-19-related acute failure (C-ARF) resulted in wide variation clinical practice. Methods Using a Delphi process, an international panel 39 experts developed practice statements C-ARF areas where is absent or limited. Agreement was defined as achieved when > 70% voted for given option Likert scale...
Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin concentrations may identify most likely to benefit from such therapy.Objectives: To test the kinetic changes and their prognostic value CRVS.Methods: analyzed serum samples enrolled ATHOS-3 (Angiotensin for Treatment of High-Output Shock) trial renin, I, before start administration or placebo after 3 hours.Measurements Main...
Abstract COVID-19 is known to cause multi-organ dysfunction 1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC) 4-5 . However, the burden infection outside respiratory tract and time viral clearance not well characterized, particularly brain 3,6-14 We performed complete autopsies on 44 patients map quantify distribution, replication, cell-type specificity across human body, including brain, from through over seven...
In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II II) their ratio may reflect differences in the response to severe vasodilation, provide novel insights into its biology, predict clinical outcomes. The objective these protocol prespecified subsequent post hoc analyses was assess epidemiology outcome associations ANG levels catecholamine-resistant shock (CRVS) enrolled Angiotensin for Treatment High-Output Shock (ATHOS-3) study.We measured at baseline,...
The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging.To test higher levels urinary [TIMP-2] × [IGFBP7] are associated with lower survival among patients same functional stage AKI.This cohort study was performed using data from...
Sepsis is a leading cause of mortality. Predicting outcomes challenging and few biomarkers perform well. Defects in the renin-angiotensin system (RAS) can predict clinical sepsis may outperform traditional biomarkers. We postulated that RAS dysfunction (elevated active renin, angiotensin 1-7 [Ang-(1-7)], angiotensin-converting enzyme 2 (ACE2) activity with depressed Ang-II ACE activity) would be associated mortality cohort septic patients.
Abstract Background Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these might impact the response angiotensin-II treatment during vasodilatory shock. Methods In a post-hoc subgroup analysis randomized, placebo-controlled, Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we compared patients with chronic angiotensin-converting use, blocker without exposure either...
About one-third of critically ill patients with acute kidney injury (AKI) develop persistently decreased function, known as disease (AKD), which may progress to chronic (CKD). Although sepsis is the most common cause AKI, little about sepsis-associated AKD.Using data from a large randomized trial including 1341 septic shock, we studied stage 2 or 3 AKI on day 1 hospitalization. We defined AKD reduced glomerular filtration rate for >7 days. In addition clinical data, measured several urinary...
Early clinical data showed that some patients with vasodilatory shock are responsive to low doses of angiotensin II. The objective this analysis was compare outcomes in requiring ≤ 5 ng kg−1 min−1 II at 30 min (≤ subgroup) maintain mean arterial pressure (MAP) ≥ 75 mmHg versus receiving > (> subgroup). Data from II-treated enrolled the ATHOS-3 trial were used. subgroup whose dose down-titrated 20 treatment initiation (79/163) had significantly lower endogenous serum levels and...