A5078857384- Pain Mechanisms and Treatments
- Venomous Animal Envenomation and Studies
- Spinal Cord Injury Research
- Ion channel regulation and function
- Poisoning and overdose treatments
- Emergency and Acute Care Studies
- Nerve injury and regeneration
- Rabies epidemiology and control
- Injury Epidemiology and Prevention
- Alcoholism and Thiamine Deficiency
- Pesticide Exposure and Toxicity
- Neurotransmitter Receptor Influence on Behavior
- Insect and Pesticide Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Respiratory and Cough-Related Research
- Innovations in Medical Education
- Pain Management and Opioid Use
- Respiratory Support and Mechanisms
- Radiation Dose and Imaging
- Cardiac Arrest and Resuscitation
- Neuropeptides and Animal Physiology
- Musculoskeletal pain and rehabilitation
East Carolina University
2016-2025
Mayo Clinic in Florida
2023
WinnMed
2023
Bellarmine University
2018
Virginia Tech
2015
Vidant Medical Center
2013-2014
Medical University of South Carolina
2008-2011
Carolinas Medical Center
2007
Piedmont International University
2006
University of Maryland, Baltimore
2005
Antagonists of glutamate receptors the N -methyl- d -aspartate subclass (NMDAR) or inhibitors nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting a clinical opportunity for use NMDAR antagonists NOS in chronic pain. Agmatine (AG), an endogenous neuromodulator present brain spinal cord, has both antagonist inhibitor activities. We report here that AG, exogenously administered to rodents, decreased hyperalgesia...
The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging.To test higher levels urinary [TIMP-2] × [IGFBP7] are associated with lower survival among patients same functional stage AKI.This cohort study was performed using data from...
About one-third of critically ill patients with acute kidney injury (AKI) develop persistently decreased function, known as disease (AKD), which may progress to chronic (CKD). Although sepsis is the most common cause AKI, little about sepsis-associated AKD.Using data from a large randomized trial including 1341 septic shock, we studied stage 2 or 3 AKI on day 1 hospitalization. We defined AKD reduced glomerular filtration rate for >7 days. In addition clinical data, measured several urinary...
Previous studies have demonstrated that the public maintains unrealistic expectations of potential for successful recovery following administration cardiopulmonary resuscitation (CPR). Others attributed this phenomenon to misrepresentation CPR outcomes on television and other sources information.To determine correlate these with various information regarding CPR, including age, television, personal medical training, programs, friends/family experience CPR.A written survey was randomly...
Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 subtype, however there no clinical evidence of a dysfunction in RLS patients. In contrast, genome-wide association studies patients have established mutation MEIS1 gene associated an increased risk developing RLS, but effect on sensorimotor function remain unknown. Mouse models for dysfunctional (D3KO) Meis1 (Meis1KO) were developed independently, each animal expresses...
Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern inflammatory features consistent macrophage activation. Identification of clinical phenotypes sepsis may allow for improved care. We aim to describe the occurrence HBD DIC a contemporary cohort determine association this phenotype known activation syndrome (MAS) biomarkers mortality. performed...
Previous studies have shown that intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with pathological characteristics similar to those associated ischemic and traumatic spinal cord (SCI). Significant changes in the functional properties sensory neurons adjacent site also been observed this model. Additionally, following QUIS injections, mechanical cold allodynia, combined excessive grooming behavior be behavioral correlates these physiological changes. These...
Embryonic stem (ES) cells have been investigated in repair of the CNS following neuronal injury and disease; however, efficacy these treatment postinjury pain is far from clear. In this study, we evaluated therapeutic potential predifferentiated mouse ES to restore sensory deficits spinal cord (SCI) mice. The model used unilateral intraspinal injection quisqualic acid (QUIS) into dorsal horn between vertebral levels T13 L1. Seven days later, 60,000 or media were transplanted site lesion....
Dopamine (DA) modulates spinal reflexes, including nociceptive in part via the D3 receptor subtype. We have previously shown that mice lacking functional (D3KO) exhibit decreased paw withdrawal latencies from painful thermal stimuli. Altering DA system CNS, D1 and systems, reduces ability of opioids to provide analgesia. Here, we tested if increased pain sensitivity D3KO might result a modified µ-opioid (MOR) function at cord level. As subtypes competing cellular effects can form...
Introduction Traditional medical school curricula rely on textbook-based learning during the first two years, often limiting students' clinical exposure. Simulation-based (SBL) provides an opportunity for students to gain exposure and competency with common procedures as well knowledge related topics. Retention of factual is a current topic discussion learners have difficulty long-term retention. The aim this study was assess if would learn, retain, enjoy emergency medicine (EM)-focused SBL....
The emergency medicine (EM) job market is increasingly focused on incentive-based reimbursement, which largely based relative value units (RVUs) and directly related to documentation of patient care. Previous studies have shown a need improve resident education in documentation. authors created educational intervention billing practices meet this identified need. hypothesis study was that would result an increase RVUs generated by EM physicians the average amount billed per patient.The used...
To determine the prevalence of herbal and/or dietary supplement use and identify patients at risk for herb-drug interactions.A convenience sample 944 were surveyed to types supplements used. Patients with heart disease, diabetes, psychiatric disorders, hypertension assessed potential interactions.One hundred thirty-five (14.3%) reported regular use. Of these, 79.3% taking concurrently prescription medications, 80.0% administered medication(s) in emergency department. Cardiac: 19.8% (n = 33)...
The administration of intravenous (IV) calcium to treat hyperkalemia resulting from digoxin poisoning is considered potentially dangerous, based on a body older literature which, in sum, reported increased cardiac glycoside toxicity with (increased arrhythmias, higher rate death).This pilot study sought determine if the chloride when compared normal saline would affect time death given hyperkalemic, toxic swine.Digoxin IV at 0.25 mg/kg was determined be appropriately for this study. When...
Study objective. Pressure-immobilization bandages sequester venom in extremities and are recommended for snakebites without local toxicity. Pilot studies were performed to determine the time of onset toxicity efficacy pressure-immobilizations a porcine model rattlesnake envenomation. Methods. After IACUC approval, anesthetized pigs injected subcutaneously distal hind leg with 200 mg Crotalus atrox venom. 1 min, received either pressure-immobilization bandage (N = 3) or no treatment 3). At 24...