Abstract Background Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated roles mechanisms inducible nitric oxide synthase (iNOS) stress-induced depression. Methods used a depressive-like state mouse model induced by unpredictable chronic mild stress (UCMS). Depressive-like behaviors were evaluated after 4 weeks UCMS, presence absence iNOS inhibitor N -(3-(aminomethyl)benzyl)acetamidine (1400 W) compared with control...

Depression is often preceded by exposure to stressful life events. Chronic stress causes perturbations in the immune system, and up-regulates production of proinflammatory cytokines, which has been proposed be associated with pathogenesis clinical depression. However, potential mechanisms stress-induced cytokines lead development depression are not well understood. Here, we sought screen main linking inflammation depression-like behavior during unpredictable, chronic, mild (UCMS), vivo. Mice...

Breastfeeding rates remain low in China and some mothers stop breastfeeding shortly after returning to work. Our study aimed investigate the association between practices of working their employment status (formal versus informal) occupational fields (agriculture related, industry business white collar). We also identified key work-related factors that influence Chinese mothers.This is a mixed-method research consisted two components. conducted cross-sectional 10,408 with children under 12...

Abstract A substantial body of social scientific research considers the negative mental health consequences media use on TikTok. Fewer, however, consider potentially positive impact that content creators (“influencers”) TikTok can have to improve outcomes; including degree which platform exposes users evidence-based communication. Our novel, influencer-led approach remedies this shortcoming by attempting change creator content-producing behavior via a large, within-subject field experiment...

Objective To investigate the association between maternal education and breast feeding in Chinese population, with a consideration of household income health-seeking behaviours. Design A nationally representative population-based cross-sectional study. Setting 77 counties from 12 geographically distinct regions China. Participants 10 408 mothers children 0 to months age, aged 15–53 years old (mean: 29.15, SD: 5.11) were classified into primary school or below group (n=781), middle (n=3842),...

Daytime napping has been postulated as both a protective and risk factor for depression in previous studies. In addition to these conflicting results, research gaps also exist with regard controlling confounding bias between daytime examining the potential association within Chinese population. To facilitate prevention diagnosis of depression, this study aims provide insight into 0.5 million adults by fully confounders, further examine modifying effects socio-economic status (SES) age. Data...

Objectives This study was conducted to examine the potential health benefits of thonningianin A (TA) on renal injury and interstitial fibrosis in diabetic nephropathy (DN) mice. Methods In this study, a DN mice model established using male C57BL/6 injected with streptozotocin (STZ, 50 mg/kg) intraperitoneally treated TA for 12 weeks. Firstly, therapeutic anti-fibrotic effects were evaluated. Secondly, effect inflammation evaluated Western blot used detect changes NLRP3/ASC/Caspase-1...

Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 subtype, however there no clinical evidence of a dysfunction in RLS patients. In contrast, genome-wide association studies patients have established mutation MEIS1 gene associated an increased risk developing RLS, but effect on sensorimotor function remain unknown. Mouse models for dysfunctional (D3KO) Meis1 (Meis1KO) were developed independently, each animal expresses...

Abstract Restless legs syndrome (RLS) is a sensory-motor neurological disorder characterized by uncomfortable sensations in the extremities, generally at night, which often relieved movements. Genome-wide association studies (GWAS) have identified mutations BTBD9 conferring higher risk of RLS. Knockout homolog mice ( Btbd9 ) and fly results motor restlessness sleep disruption. Clinical found RLS patients structural functional abnormalities striatum; however, whether how striatal pathology...

DYT1 early-onset generalized torsion dystonia is a hereditary movement disorder characterized by abnormal postures and repeated movements. It caused mainly heterozygous trinucleotide deletion in DYT1/TOR1A, coding for torsinA. The mutation may lead to partial loss of torsinA function. Functional alterations the basal ganglia circuits have been implicated this disease. Striatal dopamine receptor 2 (D2R) levels are significantly decreased patients animal models dystonia. D2R-expressing cells,...

Abstract The level‐1 (L1) radiance spectra from the first Geostationary Interferometric InfraRed Sounder (GIIRS) have been publicly available since January 2019. On account of inherent observation characteristics, operation modes, and capabilities, a complete spectrum calibration method GIIRS/L1 products is originally proposed to form latest version (V3) algorithm for implementation. Particularly, four targeted improvements in three aspects are independently established: subsample location...

In numerous animals, one essential chemosensory organ that detects chemical signals is the vomeronasal (VNO), which involved in species-specific behaviors, including social and sexual behaviors. The purpose of this study to investigate mechanism underlying processing cues semi-aquatic mammals using muskrats as animal model. Muskrat (Ondatra zibethicus) has a sensitive VNO system activates seasonal breeding behaviors through receiving specific substances, pheromones hormones. Vomeronasal...

We investigate the associations between marital status and cognitive well-being among adults aged 50 older across four settings: United States, rural South Africa, Mexico, China. Using a standardized measure of immediate word recall, we assess whether people in each non-married have worse function than their married counterparts, extent to which these vary settings. theorize that practices around marriage setting, as well social stigma attached dissolution, will reveal differing cognition....

Adiponectin is an important adipokine involved in glucose and lipid metabolism, but its secretion potential role regulating utilization during ovarian development remains unclear. This study aims to investigate the mechanism effects of follicle-stimulating hormones (FSHs) on adiponectin following impact transport granulosa cells rat ovaries. A range experimental techniques were utilized test our research, including immunoblotting, immunohistochemistry, immunofluorescence, ELISA, histological...

With rapid industrialization and urbanization, there is a growing need for women to enter the workforce, affluent people are drawn infant formula market. The breastfeeding rates in China below optimal level. Large scale quantitative research studying practices after 2015 lacking.We aimed (1) explore latest patterns (2) identify determinants of China.The study was population-based, cross-sectional survey. A multi-stage sampling technique adopted selection participants. We recruited 10,408...

Abstract Background Hypertension may be influenced by multiple factors, including social and individual determinants. Regional economic disparity in China is closely associated with such factors that give rise to diverse health outcomes. This study examines the relationship between regional development, household income, gender hypertension prevalence China. Methods utilized data from Kadoorie Biobank (CKB), a population-based on half million Chinese adults 10 geographically distinct...

The aim of this study was to investigate the presence nerve growth factor (NGF) and its receptors tyrosine kinase A (TrkA) p75 in ovaries wild ground squirrels during breeding nonbreeding seasons. In period, NGF, TrkA were immunolocalized granulosa cells, thecal interstitial cells luteal whereas both them detected only cells. Stronger immunostaining observed season compared season. Corresponding for immunohistochemical results, immunoreactivities NGF two greater then decreased a relatively...