A5084024908- Cancer-related gene regulation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Congenital Diaphragmatic Hernia Studies
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Kruppel-like factors research
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Child Nutrition and Water Access
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Neuroscience and Neuropharmacology Research
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Cervical Cancer and HPV Research
- Breastfeeding Practices and Influences
- Phosphodiesterase function and regulation
Huzhou University
2023-2025
Soochow University
2015-2024
China Medical University
2014-2024
Fourth Affiliated Hospital of China Medical University
2024
First Affiliated Hospital of Soochow University
2024
Wannan Medical College
2022-2023
Shenyang Pharmaceutical University
2015-2022
Inner Mongolia Normal University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Inner Mongolia Medical University
2020
TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding involved human cancers. However, whether how circRNAs contribute to TGF-β-induced EMT NSCLC remain vague. Here, we investigated the regulation function of RNA hsa_circ_0008305 (circPTK2) metastasis, well a link between circPTK2 transcriptional intermediary factor 1 γ (TIF1γ) NSCLC. were...
Breastfeeding rates remain low in China and some mothers stop breastfeeding shortly after returning to work. Our study aimed investigate the association between practices of working their employment status (formal versus informal) occupational fields (agriculture related, industry business white collar). We also identified key work-related factors that influence Chinese mothers.This is a mixed-method research consisted two components. conducted cross-sectional 10,408 with children under 12...
AlkB homolog 5 (ALKBH5) has been revealed as a key RNA N6-methyladenosine (m6A) demethylase that is implicated in development and diseases. However, the function of ALKBH5 TGF-β-induced epithelial-mesenchymal transition (EMT) tumor metastasis non-small-cell lung cancer (NSCLC) remains unknown. Here, we firstly show expression significantly reduced metastatic NSCLC. overexpression inhibits EMT invasion NSCLC cells, whereas knockdown promotes corresponding phenotypes. suppresses...
Expression of osteopontin correlates with tumor progression and metastasis. The mechanisms by which promotes cell survival remain unclear. Here we used short-hairpin RNA-mediated gene silencing to investigate the antitumor effects depletion in hepatocellular carcinoma (HCC).We applied polyethylenimine nanoparticles deliver a RNA for expression HCC cells. Tumorigenicity metastatic potentials cells were studied vitro nude mice. Nuclear factor-kappaB (NF-kappaB) activation was analyzed gel...
Objective To investigate the association between maternal education and breast feeding in Chinese population, with a consideration of household income health-seeking behaviours. Design A nationally representative population-based cross-sectional study. Setting 77 counties from 12 geographically distinct regions China. Participants 10 408 mothers children 0 to months age, aged 15–53 years old (mean: 29.15, SD: 5.11) were classified into primary school or below group (n=781), middle (n=3842),...
// Xin Tong 1,2,3 , Lili Li 4 Xiaoyan 1,2 Lei Heng 1 Lan Zhong Xianwei Su Rong Shi Hu Wenjia Liu 2 Baoqing Jia Xing 5 Geng Kou 1,3 Jun Han 3,6 Shangjing Guo 3 Yi Cheng Qian Tao and Yajun 1,2,3,6 International Joint Cancer Institute, The Second Military Medical University, Shanghai, China PLA General Hospital Center Key Laboratory, School of Chinese PLA, Beijing, Department Pharmacy, Liao Shandong, Epigenetics Clinical Oncology, State Laboratory Oncology in South China, Sir YK Pao for Ka...
Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation this (IL4, IL4R, IL13, GATA3, STAT6) influence risk, such influences are age-dependent, some CpG sites changes over time accordance transition. tested these hypotheses subsamples girls from a population-based birth cohort established Isle Wight, UK, 1989.Logistic regression models were...
Article26 March 2021Open Access Source DataTransparent process Quaking 5 suppresses TGF-β-induced EMT and cell invasion in lung adenocarcinoma Shengjie Wang orcid.org/0000-0003-0320-0377 Soochow University Laboratory of Cancer Molecular Genetics, Medical College University, Suzhou, China Department School Biology Basic Sciences, Medicine, Kangda Nanjing Lianyungang, ChinaThese authors contributed equally to this work Search for more papers by author Xin Tong Chang Li Thoracic Surgery, The...
Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity, which triggers cell death in various neuropathological diseases, including epilepsy. Studies have shown that inhibition activity increases the epilepsy threshold, is, has an anticonvulsant effect. However, exact role and potential mechanism seizures are still unclear. In this study, we performed RNA sequencing, functional enrichment analysis, weighted gene coexpression network analysis hippocampus tremor rats, a rat...
Spring viremia of carp virus (SVCV) is a significant pathogen that has notably hindered the advancement cyprinid aquaculture in recent years. Infections caused by SVCV are often associated with substantial economic losses due to absence effective treatment options. Previous reports indicated N-(4-methyl-2-oxo-2H-chromen-7-yl) benzenesulfonamide (N6) exhibits inhibitory effects on proliferation. This study aims comprehensively evaluate anti-SVCV N6 using healthy young as experimental model....
Background: MiRNAs may be associated with the risk of uterine sarcoma and related molecular mechanism remains unclear.Methods: A total 101 patients (cases) 54 healthy subjects (controls) were enrolled. The levels serum miR-152, miR-205, miR-222, miR-24, miR-150 sirtuin 1 (SIRT1, an NAD +-dependent class III histone deacetylase) measured by qRT-PCR. HeLa cells transfected mimics miR-152 miR-24. autophagic rates, SIRT1 acetylation microtubule-associated protein 1A/1B-light chain 3 (LC3)...
Aim We explored the association of relatively low concentrations metals in soil proximal to maternal residence during pregnancy, with intellectual disability. hypothesized different would be associated mild versus severe Method used a mixed methods design, starting retrospective cohort from 1996 2002, 10 051 pregnant mothers, sampling areas where these mothers resided and follow‐up their children determine if there was an disability outcome. tested then predicted concentration at homes,...
Screening cytosine-phosphate-guanine dinucleotide (CpG) DNA methylation sites in association with some covariate(s) is desired due to high dimensionality. We incorporate surrogate variable analyses (SVAs) into (ordinary or robust) linear regressions and utilize training testing samples for nested validation screen CpG sites. SVA account variations the not explained by specified adjust confounding effects. To make it easier users, this screening method built a user-friendly R package,...
Pyroptosis, a novel form of programmed cell death, has been implicated in neurodegeneration diseases. However, its role status epilepticus (SE)—a condition characterized by prolonged or repeated seizures—remains inadequately understood. SE were induced intraperitoneal injection pilocarpine (PILO). Neuronal excitability was assessed through electroencephalogram (EEG) recordings and patch clamp. Chromatin immunoprecipitation (ChIP) assay applied to verify the interaction phosphorylated signal...
Objectives . Inhibition of calcium‐/calmodulin‐ (CaM‐) dependent kinase II (CaMKII) is correlated with epilepsy. However, the specific mechanism that underlies learning and memory impairment neuronal death by CaMKII inhibition remains unclear. Materials Methods In this study, KN93, a inhibitor, was used to investigate role during epileptogenesis. We first identified differentially expressed genes (DEGs) in primary cultured hippocampal neurons or without KN93 treatment using RNA‐sequencing....
We compared hospital encounters between adolescents and young adults with fragile X syndrome (FXS) to peers intellectual disability (ID) from other causes, autism spectrum disorder (ASD), a comparison group without these conditions matched by gender, age, insurance coverage. Those FXS, ASD, or ID were more likely have had encounters. In terms of age groups, we found mental illness hospitalizations decreased during adulthood as adolescence for those that unrelated FXS (e.g., respiratory,...
As research into periventricular leukomalacia (PVL) gradually increases, concerns are emerging about long‑term neuron injury. The present study aimed to investigate neuronal injury and the relevant alterations in apoptosis autophagy a PVL model established previously. A rat of hypoxia‑ischemia‑induced was established. In group, Sprague‑Dawley (SD) rats [postnatal day 3 (P3)] were subjected right common carotid artery ligation followed by suturing exposed 6‑8% oxygen for 2 h; control SD (P3)...
In the field of computer vision, multi-object tracking tasks have been widely used in pedestrians and vehicles, but application fish is relatively scarce. Therefore, this paper takes Atlantic salmon as research object, collects industrial recirculating aquaculture videos, constructs a dataset MOTSALMON for research. The task challenging. When swim underwater, motion blur serious law highly nonlinear. paper, multiple scales YOLOv8 are detectors combined with advanced trackers to use train...