A5101892400- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Antibiotic Resistance in Bacteria
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmaceutical and Antibiotic Environmental Impacts
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
Hangzhou DAC Biotech (China)
2025
Shandong First Medical University
2019-2025
Shandong Tumor Hospital
2019-2025
Qingdao University
2025
Ningbo Medical Center Lihuili Hospital
2024
Shanghai East Hospital
2023
Third Xiangya Hospital
2023
Central South University
2023
Peking University
2020-2022
Changchun University of Chinese Medicine
2022
Background: Head and neck squamous cell carcinoma (HNSCC) are head cancers.On the other hand, ferroptosis is a novel iron-dependent ROS reliant type of death observed various disease conditions.Method: We constructed prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC.Results: identified 25 differently associated with prognosis HNSCC.Kaplan-Meier analyses revealed high-risk poor HNSCC.Moreover, AUC was 0.782, underscoring their utility...
Carbapenemase-producing Klebsiella pneumoniae (CPKP) strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the circulating clones and analyze clinical molecular characteristics CPKP in our hospital.A total 74 carbapenemase producers collected from hospital 2012 2014 were analyzed prevalence extended-spectrum β-lactamase (ESBLs), plasmid-mediated quinolone resistance genes (PMQRs), exogenously acquired 16S rRNA methyltransferase (16S-RMTase),...
Abstract Combining immune checkpoint therapy (ICT) and targeted holds great promises for broad long-lasting anti-cancer therapies. However, combining ICT with anti-PI3K inhibitors have been challenging because the multifaceted effects of PI3K on both cancer cells within tumor microenvironment. Here we find that intermittent but not daily dosing a PI3Kα/β/δ inhibitor, BAY1082439, Pten -null prostate models could overcome resistance unleash CD8 + T cell-dependent anti-tumor immunity in vivo....
BAL1 is a transcription modulator that overexpressed in chemoresistant, diffuse large B-cell lymphomas (DLBCLs). complexes with recently described DELTEX family member termed BBAP. Herein, we characterized and BBAP expression primary DLBCL subtypes defined by their comprehensive transcriptional profiles. were most abundant brisk host inflammatory response, designated response (HR) tumors. Although these DLBCLs include significant numbers of tumor-infiltrating lymphocytes interdigitating...
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid (AML). It characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates leukemia-retinoic acid receptor α (PML-RARA) fusion oncogene. Although this oncogene known to initiate APL in mice, other cooperating mutations, as yet ill defined, are important for disease pathogenesis. To identify these, we used mouse model APL, whereby PML-RARA expressed cells leads myeloproliferative ultimately evolves into APL....
Radiotherapy for esophageal squamous cell carcinoma (ESCC) patients is limited by resistance to ionizing radiation (IR). However, the roles and mechanisms of microRNAs in radioresistance are obscure. Here, we investigated that microRNA-205 (miR-205) was upregulated radioresistant (RR) ESCC cells compared with parental cells. Overexpression miR-205 promoted colony survival post-IR, whereas depletion sensitized IR vitro vivo. Further, demonstrated enhancing DNA repair, inhibiting apoptosis...
Abstract Objective In total, 97 carbapenem-resistant Enterobacteriaceae (CRE) were collected from 17 hospitals located in Nanjing, Southeast China, and analyzed for epidemiological characteristics. Methods Antimicrobial susceptibility was determined; followed by determination of the prevalence resistance determinants, including extended-spectrum β-lactamase (ESBLs), plasmid-mediated AmpC enzyme (pAmpCs), quinolone genes (PMQRs), fosfomycin gene exogenously acquired 16S rRNA methyltransferase...
// Xin Tong 1,2,3 , Lili Li 4 Xiaoyan 1,2 Lei Heng 1 Lan Zhong Xianwei Su Rong Shi Hu Wenjia Liu 2 Baoqing Jia Xing 5 Geng Kou 1,3 Jun Han 3,6 Shangjing Guo 3 Yi Cheng Qian Tao and Yajun 1,2,3,6 International Joint Cancer Institute, The Second Military Medical University, Shanghai, China PLA General Hospital Center Key Laboratory, School of Chinese PLA, Beijing, Department Pharmacy, Liao Shandong, Epigenetics Clinical Oncology, State Laboratory Oncology in South China, Sir YK Pao for Ka...
Metastasis is the major cause for high mortality of lung cancer with underlying mechanisms poorly understood. The scaffolding protein neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) has been identified as a pro-metastasis gene in several types cancers including melanoma and breast cancer. However, exact role related mechanism NEDD9 regulating metastasis still remain largely unknown. Here, we demonstrate that knockdown significantly inhibits migration, invasion cells...
Neoadjuvant therapy is widely used for esophageal cancer (EC), but optimal treatment regimens and predictive factors outcomes remain unclear. This study retrospectively analyzed data from EC patients who underwent neoadjuvant therapy. The chi-square test or Fisher's exact was utilized to examine differences in general clinicopathological between benefit groups. Survival analyses were conducted using Kaplan-Meier methods. Cox univariate multivariate regression employed identify independent...
11505 Background: Anti-PD-1(L1) therapies appear to be less efficacious in NSCLC patients whose tumors have EGFR activating mutations, but the underlying mechanism is poorly understood. We investigated relationship between Methods: Flow cytometry and/or quantitative PCR were used evaluate genes and proteins five mt cell lines 6 wt lines. Anti-EGFR TKIs gefitinib osimertinib at concentrations ranging from 0.001-100uM; EGF was 50 ng/mL. CP1108/NCT01693562 a nonrandomized phase 1/2 trial...
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to assess independent prognostic value KIF20A in terms overall survival (OS) recurrence-free (RFS). Results showed that normal liver tissues had very low expression compared with other cohorts TCGA. However, primary HCC (N = 371) significantly elevated than...
The malignant progression from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive (MIBC) is common and has detrimental effect on patients. We aimed elucidate the underlying mechanisms of an immunological perspective establish a reliable signature for prognostic prediction immunotherapeutic strategies.The Cell Type Identification by Estimating Relative Subsets RNA Transcripts algorithm was applied GSE32894 data set identify different tumor-infiltrating immune cells involved in...
Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing systemic immune status, are shown to have complicated relationships tumor angiogenesis, and proved be associated survival NSCLC patients. However, information from baseline factors relatively limited, which cannot reflect dynamic changes status during bevacizumab treatment....
Introduction Follicular thyroid carcinoma (FTC) is the second most common malignancy and characterized by a higher risk of distant metastasis compared to papillary cancer. Intraoperative frozen section (IOFS) diagnosis FTC challenging due its limited sensitivity accuracy, leading uncertainty in intraoperative surgical decision-making. In response, we developed predictive model assess follicular nodules identified as suspicious for neoplasm IOFS. Methods This was derived from preoperative...