A5100421809- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- MicroRNA in disease regulation
- Cancer Research and Treatments
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Ginseng Biological Effects and Applications
- RNA regulation and disease
- Immune cells in cancer
- Virus-based gene therapy research
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Heavy Metal Exposure and Toxicity
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- RNA Research and Splicing
- NF-κB Signaling Pathways
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
Jilin University
2016-2025
Capital Medical University
2021-2025
Peking University
2016-2025
Sun Yat-sen University
2015-2025
Shandong First Medical University
2024-2025
Shandong Tumor Hospital
2012-2025
Oil Crops Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Lanzhou University
2016-2025
Lanzhou University Second Hospital
2024-2025
Receptor-interacting protein 3 (Ripk3)-mediated necroptosis contributes to cardiac ischaemia-reperfusion (IR) injury through poorly defined mechanisms. Our results demonstrated that Ripk3 was strongly upregulated in murine hearts subjected IR and cardiomyocytes treated with LPS H2O2. The higher level of positively correlated the infarction area expansion, dysfunction augmented necroptosis. Function study further illustrated evoked endoplasmic reticulum (ER) stress, which accompanied an...
Abstract Therapeutic antibodies targeting PD-1 have made major breakthroughs in cancer treatment. However, the majority of colorectal (CRC) cases are microsatellite stable (MSS) and do not respond to anti-PD-1-based immunotherapy. Combination therapy will be an ideal strategy overcome this limitation. Gegen Qinlian decoction (GQD), a classical traditional Chinese medicine (TCM) formula, has been clinically proven effective treatment ulcerative colitis (UC) type 2 diabetes mellitus. Here,...
The death of cardiomyocytes either through apoptosis or necroptosis is the pathological feature cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a mitochondrially-localized serine/threonine-protein phosphatase, functions as novel inducer necroptosis. However, intense debate exists regarding effect PGAM5 on I/R-related cardiomyocyte death. Using cardiac-specific knockout (PGAM5CKO) mice, we comprehensively investigated precise contribution and molecular mechanism...
The mammalian CNS contains an abundance of chelatable Zn(2+) sequestered in the vesicles glutamatergic terminals. These are particularly numerous hippocampal mossy fiber synapses hilar and CA3 regions. Our recent observation frequency-dependent release from synaptic terminals subsequent entry into postsynaptic neurons has prompted us to investigate role synaptically released induction long-term potentiation (LTP) field hippocampus. rapid removal with membrane-impermeable chelator CaEDTA (10...
Zn 2+ is found in glutamatergic nerve terminals throughout the mammalian forebrain and has diverse extracellular intracellular actions. The anatomical location possible synaptic signaling role for this cation have led to hypothesis that released from presynaptic boutons, traverses cleft, enters postsynaptic neurons. However, these events not been directly observed or characterized. Here we show, using microfluorescence imaging rat hippocampal slices, brief trains of electrical stimulation...
We have analyzed the fate of several integral membrane proteins nuclear envelope during mitosis in cultured mammalian cells to determine whether are present a vesicle population distinct from bulk ER membranes after mitotic disassembly or dispersed throughout ER. Using immunofluorescence staining and confocal microscopy, we compared localization two inner (laminaassociated polypeptides 1 2 [LAP1 LAP2]) pore protein (gp210) distribution membranes, which was determined with lipid dyes (DiOC6...
ABSTRACT Phage-coded lysin is an enzyme that destroys the cell walls of bacteria. Phage could be alternative to conventional antibiotic therapy against pathogens are resistant multiple antibiotics. In this study, a novel staphylococcal phage, GH15, was isolated, and endogenous lytic (LysGH15) expressed purified. The LysGH15 displayed broad spectrum; in vitro treatment killed number Staphylococcus aureus strains rapidly completely, including methicillin-resistant S. (MRSA). animal...
Here we aimed to firstly investigate the role of miR-27a in proliferation and multidrug resistance gastric cancer cells. The cells was detected using MTT assay, soft agar flow cytometry nude mice real-time PCR, western blot reporter gene etc. Down-regulation could inhibit porliferation vitro vivo. also confer sensitivity drugs on cells, might increase accumulation decrease releasing amount adriamycin significantly expression P-glycoprotein transcriptional activity cyclin D1, up-regulate p21....
Background: Bladder cancer is a common serious disease around the world. Long noncoding RNAs (lncRNAs) have been demonstrated to participate in development and progression of various cancers, including bladder cancer. The aim this study was investigate effects lncRNA taurine upregulated gene 1 (TUG1) on proliferation apoptosis cell lines underlying mechanism. Methods: levels TUG1 were detected by quantitative real time polymerase chain reaction (qRT-PCR) tissues cells. mRNA protein zinc...
Hypoxia inducible factor 1 (HIF-1) is a transcription composed of two subunits, namely, HIF-1α and HIF-1β, in which HIF-1β constitutively expressed. HIF-1 upregulates several hypoxia-responsive proteins, including angiogenesis factors, glycolysis solution enzymes, cell survival proteins. also associated with the degree inflammation tumor region, but exact mechanism remains unclear. This study aims to identify molecular recruiting monocytes/macrophages by pancreatic ductal adenocarcinoma...
Albumin absorbed by renal tubular epithelial cells induces inflammation and plays a key role in promoting diabetic kidney disease (DKD) progression. Macrophages are prominent inflammatory the kidney, their there is dependent on phenotypes. However, whether albuminuria influences macrophage phenotypes underlying mechanisms during development of DKD still unclear. We found that M1 macrophage-related markers were increased diabetes mellitus (DM) mouse tissues with DKD, coculture extracellular...
, especially hypervirulent
Bladder cancer (BLCA) is one of the ten most common cancers worldwide. However, deregulation PROS1 and its specific function in BLCA not well understood. By combining proteomic transcriptomic datasets, we discovered expression was significantly reduced tissues revealed clinical relevance with BLCA. Analysis multiple datasets consistently showed group linked to cancer-promoting pathways, more aggressive characteristics, a greater chance responding positively immunotherapy. Next, various...
Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However, the correlation between heterodimeric hypoxia-inducible factor-1 (HIF-1) multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) has not been clearly investigated. This study aims at examining expression levels of HIF-1α MDR1/P-gp human colon carcinoma tissues cell lines (HCT-116, HT-29, LoVo, SW480) ascertaining whether plays an important role tumor MDR1/P-gp. The distribution P-gp...