A5101871036- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- Synthesis and biological activity
- Fault Detection and Control Systems
- Control Systems and Identification
- Neural Networks and Applications
- Crystal structures of chemical compounds
- Microstructure and mechanical properties
- Lung Cancer Research Studies
- Mineral Processing and Grinding
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Surface Treatment and Residual Stress
- Periodontal Regeneration and Treatments
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Integrated Energy Systems Optimization
- Angiogenesis and VEGF in Cancer
- Structural Health Monitoring Techniques
- Metal and Thin Film Mechanics
- Extracellular vesicles in disease
- Power Systems and Renewable Energy
- Spinal Cord Injury Research
- Image and Signal Denoising Methods
Sichuan University
2004-2025
Zhejiang University of Technology
2017-2024
Anhui Medical University
2024
Xi'an Jiaotong University
2024
Wannan Medical College
2024
First Affiliated Hospital of Anhui Medical University
2024
Jiangsu University of Technology
2022-2024
Tiangong University
2024
Shanghai University
2021-2023
Chinese Academy for Environmental Planning
2023
Multidrug resistance (MDR) is one of the major reasons chemotherapy-based treatments fail. Hypoxia generally associated with tumor chemoresistance. However, correlation between heterodimeric hypoxia-inducible factor-1 (HIF-1) and multidrug (MDR1) gene/transporter P-glycoprotein (P-gp) remains unclear. This study aims to explore molecular mechanisms reversing colon cancer MDR by focusing on target gene HIF-1α.A chemotherapeutic sensitivity assay was used observe efficiency reversal in LoVo...
Abstract Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. In this study, simvastatin was incorporated into the mesoporous hydroxyapatite microspheres (MHMs) synthesized through a microwave-assisted hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as an organic phosphorous source. The effects of simvastatin-loaded MHMs (S-MHMs) on differentiation rat marrow mesenchymal stem cells (rBMSCs) angiogenesis...
Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However, the correlation between heterodimeric hypoxia-inducible factor-1 (HIF-1) multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) has not been clearly investigated. This study aims at examining expression levels of HIF-1α MDR1/P-gp human colon carcinoma tissues cell lines (HCT-116, HT-29, LoVo, SW480) ascertaining whether plays an important role tumor MDR1/P-gp. The distribution P-gp...
Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction a novel biomimetic scaffold optimized bone augmentation Weilin Yu,1,* Tuan-Wei Sun,2,3,* Chao Qi,2,3 Zhenyu Ding,1 Huakun Zhao,1 Shichang Zhongmin Shi,1 Ying-Jie Zhu,2,3 Daoyun Chen,1 Yaohua He1,4 1Department Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 2State Key Laboratory High Performance Ceramics and Superfine Microstructure, Institute Ceramics, Chinese Academy Sciences,...
Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, similarity inorganic component osseous tissue. In this work, strontium (Sr)-doped amorphous (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source ions. The SrAPMs showed mesoporous structure relatively high area. Compared with hydroxyapatite...
The development of multifunctional biomaterials with drug delivery ability, and pro-osteogenic pro-angiogenic activities has garnered increasing interest in the field regenerative medicine. In present study, hypoxia-mimicking copper (Cu)-doped mesoporous hydroxyapatite (HAP) microspheres (Cu-MHMs) were successfully synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. Cu-MHMs doped 0.2, 0.5 1 mol% Cu prepared. consisting HAP nanorods...
Treatment for spinal cord injury (SCI) remains a challenge worldwide, and inflammation is major cause of secondary after SCI.Peripheral macrophages (PMs) have been verified as key factor that exert anti-inflammatory effects SCI, but the mechanism unidentified.As local macrophages, microglia also significant especially polarization.Exosomes show source cell-like biological functions to target cells subject much research in recent years.Thus, we hypothesized PM-derived exosomes (PM-Exos) play...
Autophagy is a cellular degradation process for the recycling of damaged or superfluous intracellular compartments to provide an alternative energy source during periods metabolic stress maintaining cell homeostasis and viability. Although autophagy in different contexts have been shown use similar signaling pathways, exact molecular regulation has found be cell-type dependent.We used rapamycin trigger nitric oxide (NO) inhibit prostate cancer cells. IWP-2 was β-catenin signaling....
Abstract In bone remodeling, osteogenesis is closely coupled to angiogenesis. Bone tissue engineering using multifunctional bioactive materials a promising technique which has the ability simultaneously stimulate and angiogenesis for repair of defects. We developed mesoporous glass (MBG)-doped poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) composite scaffolds as delivery vehicle. Two molecules, dimethyloxalylglycine (DMOG), small-molecule angiogenic drug, recombinant human...
Although immune checkpoint inhibitors (ICIs) provide unprecedented survival improvement for patients with advanced non-small cell lung cancer (NSCLC), disease progression inevitably occurs. After ICIs failure, limited data exist on whether ICI-based treatment beyond (TBP) may be beneficial to NSCLC. This retrospective study aimed evaluate the efficacy of this approach in NSCLC and identify potential factors.Patients stage IV who received after failure prior PD-1/PD-L1 inhibitor treatments...
The lack of a thorough understanding the Vif–inhibitor complex severely limits discovery and structure optimization Vif inhibitors. By employing blind docking, focused MD simulations MM/GBSA calculations, we found that binding mode C10a which is located at BC box domain Vif, has good correlation (R2 = 0.941) between experimental calculated pIC50. Moreover, all five RN-18 analogues share common pattern to inhibit degradation A3G: ring C inserts into forms strong nonpolar interaction with...
Lymphoepithelioma-like carcinoma (LELC) is a rare malignant tumor of the lung. It related to EB virus infection. Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are rarely found in this disease, while high level programmed cell death ligand 1 (PD-L1) expression observed. Here series patients with advanced LELC treated immunotherapy were summarized.This retrospective, observational study was conducted who pathologically confirmed, metastatic or recurrent patients....
Endostatin is an important endogenous inhibitor of neovascularization, which has been widely used in anti-angiogenesis therapy for cancer. To fully explore the potential endostatin, we evaluated anti-tumor efficacy combination recombinant human endostatin adenovirus and low-dose gemcitabine nude mice. We injected intratumorally plus a low dose i.p. routinely. The treatment produced no side-effects, resulted marked suppression tumor formation growth established lung carcinoma xenografts mice,...