Diabetic wound is hard to heal mainly because of the difficulty in vascularization area. Accumulating results have shown that desferrioxamine (DFO) can promote secretion hypoxia inducible factor-1 (HIF-1α), thereby upregulating expression angiogenic growth factors and facilitating revascularization. Our preliminary study has demonstrated Si ions bioglass (BG) upregulate vascular endothelial factor (VEGF) expression, thus promoting It hypothesized combined use BG DFO may a synergistic effect...

Abstract STEM education has received increasing attention in recent years. However, developing valid and reliable assessment of interdisciplinary learning been a challenge. This study is comprehensive review during the last two decades. A total 49 empirical research articles were collected from an initial library 635 focusing on education. two-dimensional framework was developed to examine literature. The first dimension concerns nature disciplines being assessed includes three categories:...

Background — Inducible nitric oxide synthase (iNOS) is expressed in the myocardium after myocardial infarction (MI) and heart failure. Its pathophysiological role these conditions, however, not clear. We hypothesized that increased NO production from iNOS expression causes dysfunction results higher mortality MI. Methods Results MI was induced by left coronary artery ligation −/− mutant wild-type mice. Mortality followed up for 30 days. resulted a significant increase both mice compared with...

Abstract Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. In this study, simvastatin was incorporated into the mesoporous hydroxyapatite microspheres (MHMs) synthesized through a microwave-assisted hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as an organic phosphorous source. The effects of simvastatin-loaded MHMs (S-MHMs) on differentiation rat marrow mesenchymal stem cells (rBMSCs) angiogenesis...

Traditional therapeutic methods for skin wounds have many disadvantages, and new wound dressings that can facilitate the healing process are thus urgently needed. Platelet-rich plasma (PRP) contains multiple growth factors (GFs) shows a significant capacity to heal soft tissue wounds. However, these GFs short half-life deactivate rapidly; we therefore need sustained delivery system overcome this shortcoming. In study, poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide)...

Using multiple representations and argumentation are two fundamental processes in science. With the advancements of information communication technologies, these blended more so than ever before. However, little is known about how interact with each other student learning. Hence, we conducted a design-based study order to distill relationship between processes. Specifically, designed learning unit on nuclear energy implemented it group preservice middle school teachers. The participants used...

The Outcome-Based education micro course teaching can effectively solve the problem of "what kind person to cultivate" and has attracted much attention from industry. However, in reality, it not had a substantial impact on improving quality talent cultivation. This article analyzes practical problems under concept Education， proposes corresponding improvement methods, which have certain significance for promoting development assisted enhancing value teaching.

Abstract This case study describes a teacher's development of and creativity in manipulating physical models an astronomy course for in‐service science teachers K‐8. Specifically, she organized data table from several charts numbers, constructed moon‐ball model addition to 2‐D model, created hula hoop as concrete realization her mental model. Examination the transformation construction processes revealed how revised existing added new elements. These reconstruction experiences afforded with...

Pesticide poisoning rates remain high among farmworkers despite programs aimed at reducing pesticide exposure.A cross-sectional study was conducted 187 Hispanic in North Carolina. Farmworkers were interviewed to determine the association between safety training and knowledge about pesticides use of personal protective equipment (PPE).Use PPE higher who reported wearing gloves reduced harmful effects (adjusted odds ratio, 5.73; 95% confidence interval, 2.20-14.92) those received extension...

Scientific modeling has been advocated as one of the core practices in recent science education policy initiatives. In modeling-based instruction (MBI), students use, construct, and revise models to gain scientific knowledge inquiry skills. Oftentimes, benefits MBI have documented using assessments targeting students' conceptual understanding or affective domains. Fewer studies used directly built on ideas modeling. The purpose this study is synthesize examine modeling-oriented (MOA) last...

Metabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on metabolic basis sarcopenia muscle-related parameters among older adults remain incompletely understood. This study aimed to identify associations metabolites with its components, explore perturbations in men, who have a higher prevalence than women.

College science education needs to foster students' habit of mind beyond disciplinary constraints. However, little research has been devoted assessing interdisciplinary understanding. To address this problem, we formed a team experts from different disciplines develop assessments that target introductory college-level science. We started our project by focusing on osmosis, topic involves knowledge multiple disciplines. developed an instrument and administered it 3 classes college students. A...

Abstract This department column explores digital and disciplinary literacies across learning contexts disciplines within outside of school. Digital enhancements will encourage readers to post questions, comments, connections.

Understanding frames of reference is critical in describing planetary motion and learning astronomy. Historically, the geocentric heliocentric models were defended advocated against each other. Today, there are still many people who do not understand relationship between two models. This topic adequately treated astronomy instruction unstudied science education research. The present small‐scale study suggests that teachers K–8 hold alternative conceptions about solar system. Most 14 believed...

Cartilage regeneration is a promising potential therapy for articular cartilage defects and adult stem cells serve key role in regenerative medicine. Adipose‑derived (ADSCs) have been identified as an alternative source of recent years can be differentiated into numerous types cell, including chondrocytes, adipocytes osteoblasts. However, their clinical use restricted by the proliferation cells, tendency to dedifferentiate. Platelet‑rich plasma (PRP) has recently emerged bioactive material...

Students need to think and work across disciplinary boundaries in the twenty-first century. However, it is unclear what interdisciplinary thinking means how analyze interactions teamwork. In this paper, drawing on multiple theoretical perspectives empirical analysis of discourse contents, we formulate a framework that helps reasoning communication (IRC) processes collaboration. Specifically, propose four interrelated IRC processes—integration, translation, transfer, transformation, develop...