A5049167024- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Bone health and treatments
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Total Knee Arthroplasty Outcomes
- Bone health and osteoporosis research
- Circular RNAs in diseases
- Pomegranate: compositions and health benefits
- Spinal Fractures and Fixation Techniques
- Inflammatory mediators and NSAID effects
- Musculoskeletal pain and rehabilitation
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Medicinal Plants
- Extracellular vesicles in disease
- Autoimmune and Inflammatory Disorders Research
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Trace Elements in Health
- Pelvic and Acetabular Injuries
Soochow University
2016-2025
First Affiliated Hospital of Soochow University
2016-2025
New York University Shanghai
2024
Shanghai University
2024
Soochow University
2021-2023
Changshu No.1 People's Hospital
2022
Yuhuangding Hospital
2015
Qingdao University
2015
Abstract Immune response and new tissue formation are important aspects of repair. However, only a single aspect is generally considered in previous biomedical interventions, the synergistic effect unclear. Here, dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn 2+ ) osteoinductive growth factors BMP-2 peptide) designed via mussel adhesion-mediated ion coordination molecular clicking strategy. Compared to bare TiO 2 group, can increase M2 macrophage recruitment by up...
Diabetes mellitus is a chronic metabolic disease with proinflammatory microenvironment, causing poor vascularization and bone regeneration. Due to the lack of effective therapy one-sided focus on direct angiogenic properties biomaterials osteogenesis stimulation, treatment diabetic defect remains challenging complex. In this study, using gelatin methacryloyl (GelMA) as template, lithium (Li) -modified bioglass-hydrogel for regeneration developed. It exhibits sustained ion release better...
Polyetheretherketone (PEEK) is a desirable alternative to conventional biomedical metals for orthopedic implants due the excellent mechanical properties. However, inherent bioinertness of PEEK contributes inferior osseointegration implants, especially under pathological conditions osteoporosis. Herein, programmed surface designed and fabricated on dictate osteoimmunomodulation bone regeneration sequentially. A degradable hybrid coating consisting poly(lactide-co-glycolide) alendronate (ALN)...
Nanozymes are considered to represent a new era of antibacterial agents, while their efficiency is limited by the increasing tissue depth infection. To address this issue, here, we report copper and silk fibroin (Cu-SF) complex strategy synthesize alternative single-atom nanozymes (SAzymes) with atomically dispersed sites anchored on ultrathin 2D porous N-doped carbon nanosheets (CuN x -CNS) tunable N coordination numbers in CuN (x = 2 or 4). The -CNS SAzymes inherently possess triple...
Accumulating evidence indicates that intracellular reactive oxygen species (ROS) production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation. Interestingly, ROS are known as oxidizing agents exert dose-dependent biphasic properties remodeling, including preventing activity but accelerating resorption. mainly composed of superoxide anion radical, hydroxyl nitric oxide, and two-electron reduction product hydrogen peroxide, which important...
In this study, we investigated the mechanisms by which puerarin alleviates osteoclast-related loss of bone mass in ovariectomy (OVX)-induced osteoporosis model mice. Puerarin-treated OVX mice exhibited higher density, fewer tartrate-resistant acid phosphatase (TRAcP)-positive osteoclasts, and levels lower reactive oxygen species (ROS) within tissues than vehicle-treated Puerarin suppressed vitro osteoclast differentiation, hydroxyapatite resorption activity, expression...
Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical physicochemical tolerance. However, its biological inertness, poor osteoinduction, weak antibacterial activity make the clinical applications in a dilemma. Inspired by mussel adhesion mechanism, here we reported biomimetic surface strategy for rational integration optimization of anti-infectivity osteo-inductivity onto PEEK surfaces using foot proteins (Mfps)-mimic peptide with...
Activated fibroblast-like synovial (FLS) cells are regarded as an important target for rheumatoid arthritis (RA) treatment via starvation therapy mediated by glucose oxidase (GOx). However, the hypoxic RA-FLS environment greatly reduces oxidation process of and leads to a poor therapeutic effect GOx-based therapy. In this work, we designed hollow mesoporous copper sulfide nanoparticles (CuS NPs)-based smart GOx/atovaquone (ATO) codelivery system (named V-HAGC) targeting realize O2-economized...
Glucocorticoids (GCs) are used in treating viral infections, acute spinal cord injury, autoimmune diseases, and shock. Several patients develop GC-induced osteonecrosis of the femoral head (ONFH). However, pathogenic mechanisms underlying ONFH remain poorly understood. GC-directed bone marrow mesenchymal stem cells (BMSCs) fate is an important factor that determines ONFH. At high concentrations, GCs induce BMSC apoptosis by promoting oxidative stress. In present study, we aimed to elucidate...
Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) a DNA demethylase that regulates cellular function and differentiation potential. Macroautophagy/autophagy maintains homeostasis recycling unnecessary damaged organelles. This study revealed promoted loss in oophorectomized (OVX) mice osteoclast regulating autophagy. Tet2 knockdown inhibited autophagy vitro. Mechanistically, increased...
The main target of current drugs for alleviating bone loss is osteoclasts. However, the long-term application such will also cause side effects. Therefore, it great need to develop new and safer therapeutics osteoporosis. In recent years, drug development based on gut microbiota has gradually attracted attention. This manuscript investigates inhibitory effect urolithin B (UB) osteoclastogenesis differentiation in vitro ovariectomized (OVX) mice.CCK-8 was used analyse cytotoxicity UB; BMMs...
Nucleus pulposus (NP) cell (NPC) senescence is one of the main causes intervertebral disc degeneration (IVDD). However, underlying mechanism NPC still unclear. The cannabinoid type 2 receptor (CB2R) a member system and plays an important role in antioxidative stress, anti-inflammatory antisenescence activities. In this study, we used hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced model rat acupuncture IVDD to explore CB2R vitro vivo. First, confirmed that expression p16INK4a NP...
Abstract The homeostasis of bone microenvironment is the foundation health and comprises 2 concerted events: formation by osteoblasts resorption osteoclasts. In early 21st century, leptin, an adipocytes-derived hormone, was found to affect through hypothalamic relay sympathetic nervous system, involving neurotransmitters like serotonin norepinephrine. This discovery has provided a new perspective regarding synergistic effects endocrine systems on skeletal homeostasis. Since then, more...