A5011434153- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Inflammatory Bowel Disease
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Ginseng Biological Effects and Applications
- Mycobacterium research and diagnosis
- Bone Metabolism and Diseases
- Nephrotoxicity and Medicinal Plants
- Biochemical and Structural Characterization
- Viral Infections and Vectors
- Bioinformatics and Genomic Networks
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
Hangzhou Hospital of Traditional Chinese Medicine
2019-2025
Second Hospital of Anhui Medical University
2023-2025
Anhui Medical University
2023-2025
Chinese PLA General Hospital
2025
Affiliated Hospital of Qingdao University
2025
Qingdao University
2025
Sichuan Agricultural University
2023-2024
Wuxi Fourth People's Hospital
2024
Jinan Central Hospital
2022-2024
Shandong First Medical University
2022-2024
In this study, we investigated the mechanisms by which puerarin alleviates osteoclast-related loss of bone mass in ovariectomy (OVX)-induced osteoporosis model mice. Puerarin-treated OVX mice exhibited higher density, fewer tartrate-resistant acid phosphatase (TRAcP)-positive osteoclasts, and levels lower reactive oxygen species (ROS) within tissues than vehicle-treated Puerarin suppressed vitro osteoclast differentiation, hydroxyapatite resorption activity, expression...
// Jie Zhu 1 , Huirong Shi Huina Liu Xiaojuan Wang and Fengmei Li 2 Department of Gynecology Obstetrics, The First Affiliated Hospital Zhengzhou University, 450052, Henan, China Obstetrics Gynecology, Central Hospital, 450000, Correspondence to: Zhu, email: jiezhu0073@163.com Keywords: cervical cancer, TUG1, SIRT1, miR-138-5p, Wnt/β-catenin Received: March 21, 2017 Accepted: April 07, Published: May 26, 2017 ABSTRACT Increasing evidences showed that long...
Bipolar disorder (BD) is a complex mental with high mortality and disability rates worldwide; however, research on its pathogenesis diagnostic methods remains limited. This study aimed to elucidate potential candidate hub genes key pathways related BD in pre-frontal cortex sample. Raw gene expression profile files of GSE53987, including 36 samples, were obtained from the omnibus (GEO) database. After data pre-processing, 10,094 selected for weighted co-expression network analysis (WGCNA)....
Abstract Background Growing evidence has suggested that immune-related genes play crucial roles in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, utility for evaluating prognosis HCC patients are still lacking. The study aimed to explore gene signatures prognostic values HCC. Methods We comprehensively integrated expression data acquired from 374 50 normal tissues Cancer Genome Atlas (TCGA). Differentially expressed (DEGs) analysis univariate Cox regression...
Glycyrrhetinic acid (GA) is a natural compound extracted from liquorice, which often used in traditional Chinese medicine. The purpose of the present study was to investigate antitumor effect GA human non‑small cell lung cancer (NSCLC), and its underlying mechanisms vitro. We have shown that suppressed proliferation A549 NCI‑H460 cells. Flow cytometric analysis showed arrested cycle G0/G1 phase without inducing apoptosis. Western blot indicated mediated G1‑phase arrest by upregulation...
Abstract Background The inhibition of osteogenic differentiation is a major factor in glucocorticoid-induced bone loss, but there currently no effective treatment. Dopamine, neurotransmitter, transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1 to D5. Although the relevance neuroendocrine system metabolism has emerged, precise effects dopamine receptor signaling on osteoblastogenesis remain unknown. Methods In vitro, western blotting and...
Abstract Asparaginyl ligases have been extensively utilized as valuable tools for site-specific bioconjugation or surface-modification. However, the application is hindered by laborious and poorly reproducible preparation processes, unstable activity ambiguous substrate requirements. To address these limitations, this study employed a structure-based rational approach to obtain high-yield high-activity protein ligase called OaAEP1-C247A-aa55-351. It was observed that OaAEP1-C247A-aa55-351...
Objective We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model predict mortality outcomes.
Systemic inflammation is closely correlated with the progression of cancer. Inflammation-related indicators has been recognized as outcome predictors in triple-negative breast cancer (TNBC). Our study aimed to investigate predictive value several inflammation-related TNBC patients underwent chemotherapy (NAC). 100 were enrolled study. Levels interleukin-6 (IL-6) detected by enzyme-linked immunosorbent assays (ELISAs). Platelet-to-lymphocyte ratio (PLR) and immune inflammatory index (SII)...
Biomimetic cytomembrane nanovaccines were fabricated to enhance immunity and induce the generation of immune response fight against breast cancer challenge.
Abstract Background In 2022, a global outbreak of monkeypox occurred with significant shift in its epidemiological characteristics. The virus (MPXV) belongs to the B.1 lineage, and genomic variations that were linked investigated this study. Previous studies have suggested viral variation plays crucial role pathogenicity transmissibility viruses. Therefore, understanding MPXV is for controlling future outbreaks. Methods This study employed bioinformatics phylogenetic approaches evaluate key...
Abstract Propionibacterium acnes induces inflammatory and plays a vital role in the formation of comedones through activation cells, keratinocytes, sebocytes. Sirtuin6 (SIRT6), along with ADP‐ribosyltransferase deacetylase, has been proposed to mediate various biological functions, including inflammation. Nevertheless, no strong experimental evidence provided support effect SIRT6 treatment situation. Therefore, this study addressed inhibitory against P. –triggered inflammation human...
Pepper is an important vegetable in the world. In this work, mRNA and ncRNA transcriptome profiles were applied to understand heterosis effect on alteration gene expression at seedling flowering stages between hybrid its parents Capsicum chinense . Our phenotypic data indicated that has dominance leaf area, plant scope, height, fruit-related traits. Kyoto Encyclopedia of Genes Genomes analysis showed nine members hormone signal transduction pathway upregulated hybrid, which was supported by...
BACKGROUND Atopic dermatitis is a chronic inflammatory disease of the skin. It has high prevalence worldwide and affected persons are prone to recurrent attacks, seriously affecting physical mental patients. The exact etiology still unclear. MATERIAL AND METHODS There 7 datasets on atopic in Gene Expression Omnibus database, including 142 lesional 134 non-lesional skin biopsy samples. Differential analysis was performed after were integrated by robust multi-array average method. Functional...
Abstract Bladder cancer is one of the most common cancers worldwide. The immune response and cell infiltration play crucial roles in tumour progression. Immunotherapy has delivered breakthrough achievements past decade bladder cancer. Differentially expressed genes immune-related (DEIRGs) were identified by using edgeR package. Gene ontology annotation Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses performed for functional enrichment analysis DEIRGs. Survival-associated IRGs...
Abstract Osteolysis around the prosthesis and subsequent aseptic loosening are main causes of failure. Inflammation due to wear particles osteoclast activation key factors in osteolysis also potential targets for treatment osteolysis. However, it is not clear whether puerarin can inhibit chronic inflammation alleviate In this study, we investigated effect on Ti particle‐induced inflammatory vivo rat femoral models vitro receptor activator nuclear factor kappa‐B ligand (RANKL)‐induced models....