A5103506046- Epigenetics and DNA Methylation
- Vestibular and auditory disorders
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Hearing Loss and Rehabilitation
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- Hearing, Cochlea, Tinnitus, Genetics
- S100 Proteins and Annexins
- Ophthalmology and Eye Disorders
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Renal and related cancers
- Ear and Head Tumors
- DNA Repair Mechanisms
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Multiple and Secondary Primary Cancers
- Genomics and Chromatin Dynamics
- COVID-19 and Mental Health
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
Chinese PLA General Hospital
2024-2025
Peking University People's Hospital
2022-2025
Peking University
2022-2025
University of Florida
2025
Florida College
2025
Huazhong University of Science and Technology
2008
Tongji Hospital
2008
Karolinska Institutet
2000-2001
Objective:Aural fullness（AF） is one of the common symptoms in ENT outpatient department, incidence about 1.4%. Some patients have an unknown etiology and are diagnosed as idiopathic ear congestion. In this paper, therapeutic effect gabapentin on some with congestion was studied. Methods:Forty-eight cases distress main complaint between January 2024 September were examined by questionnaire, specialist physical examination, pure tone audiometry acoustic impedance. Among them, 19 definite...
To analyze the correlation between prognosis of sudden total deafness (STD) and peripheral blood inflammation markers including white cell count (WBC), monocytes, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), fibrinogen (FIB).125 patients with STD who were hospitalized in our department from 2014 to 2019 enrolled. The general physical conditions, clinical manifestations, pure tone audiometry, imaging examination, collected, all divided into effective ineffective two groups...
Age-related hearing loss (ARHL) is a major cause of chronic disability among the elderly. Individuals with ARHL not only have trouble sounds, but also speech perception. As perception auditory information reliant on integration between widespread brain networks to interpret stimuli, both and extra-auditory systems which mainly include visual, motor attention systems, play an important role in compensating for ARHL.
Background The von Hippel–Lindau (VHL) mutation is an important alteration in clear cell renal carcinoma (ccRCC); however, its imaging phenotype remains unclear. Purpose To investigate whether MRI features can reflect the VHL status. Study Type Retrospective. Field Strength/Sequence 3 T/fast spin echo T2‐weighted, spin‐echo planar diffusion‐weighted, gradient recalled T1‐weighted, chemical‐shift and contrast‐enhanced T1‐weighted sequences. Population One hundred five patients with ccRCC who...
Primary cilia are present on renal tubules and implicated to play a pivotal role in transducing signals during development; however, the oncogenic of clear cell carcinoma (ccRCC) has not been examined. Here we show that VHL wild-type ccRCC lines have high incidence primary cilia, frequency is positively correlated with expression poor prognosis. Besides, depletion KIF3A IFT88, genes required for ciliogenesis, significantly inhibited tumor proliferation metastasis vitro vivo. Further analysis...
Abstract The products of proliferating cell nuclear antigen (PCNA) and flap endonuclease (FEN1) genes are multifunctional proteins that involved in DNA replication damage repair. Yeast models suggest association mutant forms PCNA FEN1 with genomic instability. In our study, we have determined the single nucleotide polymorphisms human genes. We sequenced coding region adjacent noncoding both 120 alleles (60 individuals). gene, detected 9 sequence variants Hardy-Weinberg allele frequency...
Purpose This study aimed to investigate dynamic change of permeability blood‐labyrinth barrier (BLB) after noise exposure and its effect on the drug delivery efficiency systemic administration. Methods Gadopentetate dimeglumine (Gd‐DTPA) dexamethasone (DEX) were used as tracers, magnetic resonance imaging (MRI) immunofluorescence observe BLB strong in guinea pigs. High‐performance liquid chromatography‐mass spectrometry (LC–MS) was breakdown intravenous DEX. The pigs divided into 6 groups:...
To investigate the association between DNA polymorphisms, including single-nucleotide polymorphisms (SNPs) and insertion/deletion in exon 1 promoter of CDH1 gene, risk transitional cell carcinoma (TCC) urinary bladder (TCCB).This was a hospital-based case-control study 180 patients with TCCB 110 normal controls. Genomic extracted from blood samples all participants genotypes determined using polymerase chain reaction sequencing techniques. Haplotypes were analysed appropriate software.SNPs...
<title>Abstract</title> Primary cilia are present on renal tubules and implicated to play pivotal role in transducing signals during development; however, the oncogenic of clear cell carcinoma (ccRCC) has not been examined. Here we show that VHL wild-type ccRCC lines have high incidence primary cilia, frequency is positively correlated with expression poor prognosis. Besides, depletion Kif3a or Ift88, genes required for ciliogenesis, significantly inhibited tumor proliferation metastasis...
Background The pathway by which drugs are injected subcutaneously behind the ear to act on inner has not been fully elucidated.
刘宏德 1)** 罗坤 2) 马昕 3) 翟金城 1) 谢建明 孙啸 万亚坤 4)