A5018296431- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Protein Tyrosine Phosphatases
- Advanced Proteomics Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Cancer Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Mass Spectrometry Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Metabolomics and Mass Spectrometry Studies
- Machine Learning in Bioinformatics
- Galectins and Cancer Biology
- Tryptophan and brain disorders
- Indigenous Health, Education, and Rights
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
University of Kentucky
2018-2025
Lafora disease (LD) is a fatal childhood epilepsy caused by recessive mutations in either the EPM2A or EPM2B gene. A hallmark of LD intracellular accumulation insoluble polysaccharide deposits known as bodies (LBs) brain and other tissues. In mouse models, genetic reduction glycogen synthesis eliminates LB formation rescues neurological phenotype. Therefore, LBs have become therapeutic target for ameliorating LD. Herein, we demonstrate that human pancreatic α-amylase degrades LBs. We fused...
Abstract Prostate cancer is the most common in men worldwide. Despite its prevalence, there a critical knowledge gap understanding factors driving disparities survival among different cohorts of patients with prostate cancer. Identifying molecular features separating disparate populations an important first step research that could lead to fundamental hypotheses biology, predictive biomarker discovery, and personalized therapy. N-linked glycosylation cotranslational event during protein...
Background: Microdose lithium is protective against Alzheimer’s disease (AD), although the precise mechanisms through which its effects are conferred remain unclear. Objective: To further examine during earliest stages of Aβ pathology, we evaluated whether NP03, a microdose formulation, modulates Aβ-mediated oxidative damage and neuroinflammation when applied to rat transgenic model AD-like amyloidosis overexpressing amyloid precursor protein (APP). Method: McGill-R-Thy1-APP rats wild-type...
Lafora disease (LD) is a fatal juvenile epilepsy characterized by the accumulation of aberrant glucan aggregates called bodies (LBs). Delivery protein-based therapeutics to central nervous system (CNS) for clearance LBs remains unique challenge in field. Recently, humanized antigen-binding fragment (hFab) derived from murine systemic lupus erythematosus DNA autoantibody (3E10) has been shown mediate cell penetration and proposed as broadly applicable carrier cellular targeting uptake. We...
Abstract Prostate cancer is the most common in men worldwide. Despite its prevalence, there a critical knowledge gap regarding underlining molecular events that result higher incidence and mortality rate Black men. Identifying features separate racial disparities step prostate research could lead to predictive biomarkers personalized therapy. N-linked glycosylation co-translational event during protein folding modulates myriad of cellular processes. Recently, aberrant has been reported...
Abstract Lafora disease (LD) is a fatal childhood epilepsy and non-classical glycogen storage disorder with no effective therapy or cure. LD caused by recessive mutations in the EPM2A EPM2B genes that encode phosphatase laforin an E3 ubiquitin ligase malin, respectively. A hallmark of intracellular accumulation abnormal insoluble α-linked polysaccharide deposits known as bodies (LBs) several tissues, including most regions brain. In mouse models LD, genetic reduction synthesis eliminates LB...
Abstract Lafora disease is a fatal juvenile epilepsy, characterized by the malignant accumulation of aberrant glucan inclusions called Bodies (LBs). Cerebral delivery protein-based therapeutics for clearance remain unique challenge in field. Recently, humanized antigen-binding fragment (hFab) derived from murine systemic lupus erythematosus DNA autoantibody (3E10) has been shown to mediate cell penetration and proposed as broadly applicable carrier cellular targeting uptake. We report...
<p>Supplemental Figure 2. Prostate tumor tissue exhibits decreased abundance of selected N-glycans proportional to grade.</p>
<p>Supplemental Figure Legends 1-6</p>
<p>Supplemental Figure 4. N-glycans are further elevated in adjacent benign tissue of Black patient sample.</p>
<p>Supplemental Figure 5. N-glycans as a potential biomarker for disease recurrence in Black prostate cancer patients.</p>
<p>Supplemental Figure 6. Differential N-glycan profiles for Appalachian versus non-Appalachian prostate tumor patients, separated by grade.</p>
<p>Supplemental Figure 3. Elevated N-glycans detected in grade group 1 Black patient sample.</p>
<p>Supplemental Figure 1. Hematoxylin & Eosin (H&E) staining of the three prostate TMAs used for this study.</p>
<p>Supplemental Figure Legends 1-6</p>
<p>Supplemental Figure 1. Hematoxylin & Eosin (H&E) staining of the three prostate TMAs used for this study.</p>
<p>Supplemental Figure 5. N-glycans as a potential biomarker for disease recurrence in Black prostate cancer patients.</p>
<p>Supplemental Figure 4. N-glycans are further elevated in adjacent benign tissue of Black patient sample.</p>
<p>Supplemental Figure 3. Elevated N-glycans detected in grade group 1 Black patient sample.</p>
<p>Supplemental Figure 6. Differential N-glycan profiles for Appalachian versus non-Appalachian prostate tumor patients, separated by grade.</p>
<p>Supplemental Figure 2. Prostate tumor tissue exhibits decreased abundance of selected N-glycans proportional to grade.</p>
<div>Abstract<p>Prostate cancer is the most common in men worldwide. Despite its prevalence, there a critical knowledge gap understanding factors driving disparities survival among different cohorts of patients with prostate cancer. Identifying molecular features separating disparate populations an important first step research that could lead to fundamental hypotheses biology, predictive biomarker discovery, and personalized therapy. N-linked glycosylation cotranslational event...