A5059897855- Alzheimer's disease research and treatments
- Down syndrome and intellectual disability research
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Extracellular vesicles in disease
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Cholinesterase and Neurodegenerative Diseases
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Health, Environment, Cognitive Aging
- GDF15 and Related Biomarkers
- Cardiovascular Health and Disease Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Bipolar Disorder and Treatment
- Sex and Gender in Healthcare
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
Hospital de Sant Pau
2020-2025
Universitat Autònoma de Barcelona
2020-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2024
Women's Brain Project
2018-2024
Biomedical Research Institute
2021-2022
Instituto de Salud Carlos III
2022
McGill University
2009-2021
John Wiley & Sons (United States)
2021
Université de Montréal
2016-2021
Centro de Investigación Biomédica en Red
2021
Epidemiological and experimental studies suggest that a disease-aggravating neuroinflammatory process is present at preclinical stages of Alzheimer's disease. Given individuals with Down syndrome are increased genetic risk disease therefore develop the spectrum neuropathology in uniform manner, they constitute an important population to study evolution neuroinflammation across continuum. Therefore, this cross-sectional study, we characterized brain inflammatory profile lifespan syndrome....
Given that Alzheimer's pathology develops silently over decades in Down syndrome (DS), prognostic biomarkers of dementia are a major need.We investigated the plasma levels Aβ, proNGF, tPA, neuroserpin, metallo-proteases and inflammatory molecules 31 individuals with DS (with without dementia) healthy controls. We examined associations between cognitive decline.Aβ40 Aβ42 were elevated compared to controls, even dementia. Plasma Aβ correlated rate decline across 2 years. ProNGF, MMP-1, MMP-3,...
<h3>Importance</h3> Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the<i>APOE</i>ɛ4 allele plays a role risk and age at onset dementia DS; however, data on vivo biomarkers remain scarce. <h3>Objective</h3> To investigate association clinical multimodal AD adults DS. <h3>Design, Setting, Participants</h3> This dual-center cohort study recruited DS Barcelona, Spain, Cambridge, UK, between June 1, 2009, February...
Abstract The study of sex differences in Alzheimer’s disease is increasingly recognized as a key priority research and clinical development. People with Down syndrome represent the largest population genetic link to (&gt;90% 7th decade). Yet, manifestations have not been fully investigated these individuals, who are candidates for preventive trials. In this double-centre, cross-sectional 628 adults [46% female, 44.4 (34.6; 50.7) years], we compared prevalence, well cognitive outcomes...
Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer’s disease (AD) pathology, capable triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. However, occurrence pathological relevance intracellular Aβ remain a matter controversial debate. In this study, we used multidimensional approach including high-magnification super-resolution microscopy, cerebro-spinal fluid (CSF) mass spectrometry...
Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its synaptic integrity and the phenotypic maintenance of cell bodies. progressively degenerate Alzheimer's disease Down's syndrome, their atrophy contributes to manifestation dementia. Paradoxically, brains, synthesis not affected there abundance precursor, proNGF. We have shown that this phenomenon result deficit NGF's extracellular metabolism compromises proNGF maturation...
Abstract General DNA hypomethylation is associated with Alzheimer’s disease (AD), but it unclear when starts or plays a role in AD pathology whether re-methylation would rescue early amyloid-related cognitive impairments. In an APP transgenic mouse model of AD-like amyloid we found that intraneuronal beta build-up sufficient to unleash global and beta-site precursor protein cleaving enzyme 1 (bace-1) demethylation AD-vulnerable brain regions. S-adenosylmethionine administration at these...
Background Arterial stiffness is associated with cognitive decline and dementia; however, the precise mechanisms by which it affects brain remain unclear. Methods Results Using a mouse model based on carotid calcification this study characterized that could contribute to degeneration due arterial stiffness. At 2 weeks postcalcification, attenuated resting cerebral blood flow in several regions including perirhinal/entorhinal cortex, hippocampus, thalamus, determined autoradiography ( P...
Abstract Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD individuals Down syndrome (DS). We included 366 adults DS (240 asymptomatic, 43 prodromal AD, 83 dementia) and 44 euploid cognitively normal controls. measured Single molecule array (Simoa) assay. examined diagnostic performance for detection relationship other fluid imaging...
Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role the behavioral variant of frontotemporal dementia (bvFTD) unknown.We included 216 patients with bvFTD 235 controls magnetic resonance imaging (MRI) from a large multicenter cohort. We compared characteristics cortical thickness between men women controls. followed residuals approach to study cognitive reserve.At diagnosis, showed greater atrophy burden...
The expression of matrix metallo-proteases (MMP-2, MMP-3, MMP-7, and MMP-9), plasminogen their regulators (TIMP-1, tissue activator neuroserpin) was investigated in cerebrospinal fluid (CSF) from subjective cognitive impairment (SCI) subjects, mild (MCI), Alzheimer's disease (AD) cases. ELISA analysis revealed a significant increase MMP-3 protein levels CSF AD compared to age-matched SCI MCI No differences MMP-2 MMP-9 were detected between the three groups. MMP-7 undetectable all individuals...
Abstract Introduction AF710B (aka ANAVEX 3‐71) is a novel selective allosteric M1 muscarinic and sigma‐1 receptor agonist. In 3×Tg‐AD mice, attenuates cognitive deficits decreases Alzheimer‐like hallmarks. We now report on the long‐lasting disease‐modifying properties of in McGill‐R‐Thy1‐APP transgenic (Tg) rats. Methods Chronic treatment with (10 μg/kg) was initiated postplaque 13‐month‐old Tg Drug or vehicle administered orally daily for 4.5 months interrupted 5 weeks before behavioral...
Alzheimer disease (AD) is the main medical problem in adults with Down syndrome (DS). However, associations of age, intellectual disability (ID), and clinical status progression longitudinal cognitive decline have not been established.To examine along AD continuum its related to explore presence practice effects floor repeated assessments.This a single-center cohort study (aged >18 years) DS different ID levels at least 6 months follow-up between November 2012 December 2021. The data are...
Brain-derived extracellular vesicles (BEVs) in blood allows for minimally-invasive investigations of central nervous system (CNS) -specific markers age-related neurodegenerative diseases (NDDs). Polymer-based EV- and immunoprecipitation (IP)-based BEV-enrichment protocols from have gained popularity. We systematically investigated protocol consistency across studies, determined CNS-specificity proteins associated with these protocols.