A5108167217- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutritional Studies and Diet
- Free Radicals and Antioxidants
- Schizophrenia research and treatment
- Computational Drug Discovery Methods
- Sleep and related disorders
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Obesity, Physical Activity, Diet
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Wnt/β-catenin signaling in development and cancer
- Functional Brain Connectivity Studies
- Folate and B Vitamins Research
- S100 Proteins and Annexins
University of Catania
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Oasi Maria SS
2016-2025
University Hospital of Lausanne
2025
Neurocentre Magendie
2015-2023
Inserm
2015-2023
Université de Bordeaux
2023
Centre National de la Recherche Scientifique
2019
Assistance Publique – Hôpitaux de Paris
2019
Pitié-Salpêtrière Hospital
2019
The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor protein)-overexpressing mice (Lesné 2006), neuronal cultures treated with synthetic Aβ peptides (Lambert 1998) indicate that self-association monomers into soluble oligomers is required for neurotoxicity. function monomeric unknown. evidence present CSF normal...
We used primary cultures of cortical neurons to examine the relationship between beta-amyloid toxicity and hyperphosphorylation tau protein, biochemical substrate for neurofibrillary tangles Alzheimer's brain. Exposure peptide (betaAP) induced expression secreted glycoprotein Dickkopf-1 (DKK1). DKK1 negatively modulates canonical Wnt signaling pathway, thus activating tau-phosphorylating enzyme glycogen synthase kinase-3beta. was at late times after betaAP exposure, its dependent on tumor...
Cannabis use disorder (CUD) is widespread, and there no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, signaling-specific inhibitor cannabinoid receptor 1 (CB1-SSi). AEF0117 selectively inhibits subset intracellular effects resulting from Δ9-tetrahydrocannabinol (THC) binding without modifying behavior per se. In mice non-human primates, decreased self-administration THC-related behavioral impairment producing significant adverse effects....
Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though pathogenesis this fatal disorder remains unclear, transforming growth factor-β (TGF-β)-induced differentiation proliferation recognized as primary event. The molecular pathways involved TGF-β signalling are generally Smad-dependent yet Smad-independent pathways, including phosphatidylinositol-3-kinase/protein...
Abstract Transforming Growth Factor β1 (TGF-β1) is a well-known neuroprotective and neurotrophic factor demonstrated to play role in synaptic transmission. However, its involvement physiological mechanisms underlying plasticity memory at hippocampal level has not been thoroughly investigated. Here, we examine the of TGF-β1 long-term potentiation (LTP) adult wild type mice. Our data provide evidence that administration exogenous able convert early-phase-LTP into late-phase-LTP. Furthermore,...
Sleep quality has been associated with human health and diseases, including cognitive decline dementia; however major determinants of sleep disorders are largely unknown. The aim this study was to evaluate the association between adherence Mediterranean dietary pattern in a sample Italian adults.A total 1936 individuals were recruited urban area Catania during 2014-2015 through random sampling. A food frequency questionnaire validated instruments used assess diet (Pittsburg index)....
Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. involved cellular defense mechanisms against oxidative stress, including inhibition of amyloid-beta (Aβ) aggregation scavenging reactive species. Microglia play central role pathogenesis Alzheimer's disease, promoting neuroinflammation through secretion inflammatory mediators free radicals. However, effects carnosine on microglial cells are not well...