A5063363543- Biochemical effects in animals
- Genetic Neurodegenerative Diseases
- Free Radicals and Antioxidants
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Botulinum Toxin and Related Neurological Disorders
- Tryptophan and brain disorders
- Peripheral Nerve Disorders
- Hereditary Neurological Disorders
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Transcranial Magnetic Stimulation Studies
- Healthcare and Venom Research
- Metabolism and Genetic Disorders
- Pharmacological Effects of Natural Compounds
- Liver Disease and Transplantation
- Analytical Chemistry and Sensors
- Microfluidic and Bio-sensing Technologies
- Pain Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Bee Products Chemical Analysis
University of Parma
2020-2025
Oasi Maria SS
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1993-2025
University of Catania
2013-2025
University of Reggio Calabria
2022
University of Kansas
2011-2018
Ferrarotto Hospital
2015-2017
Lawrence University
2014
University of Naples Federico II
1992-2009
University of Copenhagen
1965-2009
Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. involved cellular defense mechanisms against oxidative stress, including inhibition of amyloid-beta (Aβ) aggregation scavenging reactive species. Microglia play central role pathogenesis Alzheimer's disease, promoting neuroinflammation through secretion inflammatory mediators free radicals. However, effects carnosine on microglial cells are not well...
The aim of this study was to assess the feasibility and safety early discharge (within 72 h) after transfemoral transcatheter aortic valve implantation (TAVI) identify baseline features and/or peri-procedural variables, which may affect post-TAVI length-of-stay (LoS) duration.Patients discharged within h TAVI (early group) were compared with consecutive patients 3 days (late group). Propensity-matched cohorts a 2:1 ratio created better control confounding bias. Among 465 patients, 107...
Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations the muscles and brain possesses well-characterized antioxidant anti-inflammatory activities. In an vitro model of macrophage activation, induced by lipopolysaccharide + interferon-gamma (LPS IFN-γ), we here report ability carnosine to modulate pro-oxidant pro-inflammatory activities macrophages, representing primary cell type that activated as part immune...
Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule present at high concentrations in several mammalian excitable tissues such as muscles brain, while it can be found low a few invertebrates. has been shown to involved different cellular defense mechanisms including the inhibition protein cross-linking, reactive oxygen nitrogen species detoxification well counteraction inflammation. As part immune response, macrophages are primary...
Blood–retinal barrier (BRB) dysfunction represents one of the most significant changes occurring during diabetic retinopathy. We set up a high-reproducible human-based in vitro BRB model using retinal pericytes, astrocytes, and endothelial cells order to replicate human vivo environment with same numerical ratio layer order. Our findings showed that high glucose exposure elicited breakdown, enhanced permeability, reduced levels junction proteins such as ZO-1 VE-cadherin. Furthermore, an...
Healthy successful aging with preserved mental and cognitive health is expected to be one of the most important challenges growing old population globally. Studies investigating these multi-dimensional aspects senescence are identify potential targets for early prevention. The aim this study was investigate relation between adherence Mediterranean diet health, quality life, in middle-age older adults living Sicily, southern Italy. Data from a sample 883 individuals collected including...
Summary: We have investigated the comparative effects of estradiol benzoate (EB), antiestrogenclomiphene citrate (CC), and progesting medroxyprogesterone acetate (MPA) on seizures induced by systemic injection kainic acid (15 mg/kg i.p.) in male female rats. Subcutaneous administration for 10 days EB (10 μg/kg) or high doses CC (50 mg/kg) significantly potentiated kainate‐induced seizures, with effect being more pronounced animals. Doses 2.5 rats but were ineffective Low (0.5 exhibited a...
Depression is a risk factor for the development of Alzheimer's disease (AD), and presence depressive symptoms significantly increases conversion mild cognitive impairment (MCI) into AD. A long-term treatment with antidepressants reduces to develop AD, different second-generation such as selective serotonin reuptake inhibitors (SSRIs) are currently being studied their neuroprotective properties in In present work, SSRI fluoxetine new multimodal antidepressant vortioxetine were tested ability...
Thymoquinone (TQ), a natural polyphenol, has been associated with various pharmacological responses; however, low bioavailability of TQ limits its clinical application. Thus, novel phytosomal delivery system TQ-Phospholipon® 90H complex (TQ-phytosome) was developed by refluxing combined anti-solvent precipitation. This optimized three-factor, three-level Box-Behnken design. The TQ-phytosome size (45.59 ± 1.82 nm) and the vesicle confirmed transmission electron microscopy. in vitro release...
Abstract Engineered nanoparticles are finding a wide spectrum of biomedical applications, including drug delivery and capacity to trigger cytotoxic phenomena, potentially useful against tumor cells. The full understanding their biosafety interactions with cell processes is mandatory. Using microglial (BV-2) alveolar basal epithelial (A549) cells, in this study we determined the effects engineered carbon nanodiamonds (ECNs) on viability, nitric oxide (NO) reactive oxygen species (ROS)...