A5081281804- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Neurobiology of Language and Bilingualism
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Memory and Neural Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Palliative Care and End-of-Life Issues
- Health disparities and outcomes
- Genetic Neurodegenerative Diseases
- Spatial Neglect and Hemispheric Dysfunction
- Intensive Care Unit Cognitive Disorders
- Chronic Disease Management Strategies
- Advanced Neuroimaging Techniques and Applications
- Cognitive Functions and Memory
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Intergenerational Family Dynamics and Caregiving
- Amyotrophic Lateral Sclerosis Research
- Pharmaceutical Practices and Patient Outcomes
- EEG and Brain-Computer Interfaces
University Memory and Aging Center
2016-2025
University of California, San Francisco
2016-2025
Global Brain Health Institute
2017-2025
Trinity College Dublin
2020-2024
Center for Neurosciences
2024
Trinity College
2021-2023
RELX Group (Netherlands)
2021
University of Saint Katherine
2021
New York University Press
2019
Cambridge University Press
2019
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical success of disease-modifying therapies. We sought to improve pathological prediction by exploring clinicopathological correlations large bvFTD cohort. Among 438 whom was either top or an alternative possible clinical diagnosis, 117 had available autopsy data, including 98 primary lobar degeneration...
Abstract Executive functioning is widely targeted when human cognition assessed, but there little consensus on how it should be operationalized and measured. Recognizing the difficulties associated with establishing standard operational definitions of executive functioning, National Institute Neurological Disorders Stroke entered into a contract University California-San Francisco to develop psychometrically robust measurement tools that would accepted by neurology clinical trials research...
Few health systems have adopted effective dementia care management programs. The Care Ecosystem is a model for delivering from centralized hubs across broad geographic areas to caregivers and persons with (PWDs) independently of their system affiliations.To determine whether the in improving outcomes important PWDs, caregivers, payers beyond those achieved usual care.A single-blind, randomized clinical trial pragmatic design was conducted among PWDs caregivers. Each PWD-caregiver dyad...
Network hyperexcitability may contribute to cognitive dysfunction in patients with Alzheimer disease (AD).To determine the ability of antiseizure drug levetiracetam improve cognition persons AD.The Levetiracetam for Alzheimer's Disease-Associated Hyperexcitability (LEV-AD) study was a phase 2a randomized double-blinded placebo-controlled crossover clinical trial 34 adults AD that conducted at University California, San Francisco, and Minnesota, Twin Cities, between October 16, 2014, July 21,...
The US aging population is rapidly becoming more racially and ethnically diverse. Early diagnosis of dementia a health care priority.
Abstract Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding health disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex neurodegeneration) on brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American Caribbean (LAC) 8 non-LAC countries). Based higher-order interactions, we developed a deep learning architecture functional...
<b><i><i>Objective:</i></i></b> To evaluate the production rate of CSF in patients with differing disease states. <b><i><i>Methods:</i></i></b> The authors measured three groups patients: five PD below age 60 (aged 51 ± 4 years, mean SD), nine over 69 6 and seven dementia Alzheimer’s type (AD) 72 9 SD). This method, based on Masserman technique, employs ventricular rather than a lumbar access to space. Furthermore, volume removed during procedure is only 3 mL 10 mL....
Abstract This study tested the hypothesis that diffusion tensor imaging can detect alteration in microscopic integrity of white matter and basal ganglia regions known to be involved Parkinson's disease (PD) pathology. It was also hypothesized there is an association between abnormality PD severity subtype. Diffusion at 4 Tesla obtained 12 20 control subjects, measures fractional anisotropy mean diffusivity were evaluated using both region‐of‐interest voxel‐based methods. Movement deficits...
Apolipoprotein ε4 (apoE4) has been strongly linked with Alzheimer's disease (AD) and contributes to several other neurological disorders. We investigated the influence of allele carrier status on pattern gray matter atrophy severity in 51 patients probable AD 31 behavioral variant frontotemporal dementia (bvFTD), compared 56 healthy controls. Voxel-based morphometry was performed by using statistical parametric mapping. The frequency higher group ( P < 0.001) than controls but not bvFTD...
<h3>Objective:</h3> To determine whether oral quinacrine increases survival in sporadic Creutzfeldt-Jakob disease (sCJD). <h3>Methods:</h3> This NIH/National Institute on Aging–funded, double-blinded, placebo-controlled, stratified randomization treatment trial was conducted at the University of California, San Francisco from February 2005 through May 2009 (ClinicalTrials.gov, NCT00183092). Subjects were randomized (50:50) to (300 mg daily) or placebo with inpatient evaluations baseline, and...
Clearer delineation of the phenotypic heterogeneity within behavioral variant frontotemporal dementia (bvFTD) will help uncover underlying biological mechanisms and improve clinicians' ability to predict disease course design targeted management strategies.To identify subtypes bvFTD syndrome based on distinctive patterns atrophy defined by selective vulnerability specific functional networks in using statistical classification approaches.In this retrospective observational study, 90 patients...
<h3>Objective:</h3> The objective of this study was to determine which aspects executive functions are most affected in behavioral variant frontotemporal dementia (bvFTD) and best differentiate syndrome from Alzheimer disease (AD). <h3>Methods:</h3> We compared 22 patients diagnosed with bvFTD, 26 AD, 31 neurologically healthy controls using a conceptually driven comprehensive battery function tests, the NIH EXAMINER (http://examiner.ucsf.edu). <h3>Results:</h3> bvFTD AD were similarly...
Background/Objectives Brief cognitive screens lack the sensitivity to detect mild impairment ( MCI ) or support differential diagnoses. The objective of this study was validate 10‐minute, tablet‐based University California, San Francisco UCSF Brain Health Assessment BHA overcome these limitations. Design Cross‐sectional. Setting Memory and Aging Center. Participants Older adults (N = 347) (neurologically healthy controls (n 185), individuals diagnosed with 99), dementia 42), as normal...
<h3>Importance</h3> As the life expectancy of people with Down syndrome (DS) has markedly increased over past decades, older adults DS may be experiencing a higher incidence aging conditions. In addition to longevity, amyloid precursor protein gene located on chromosome 21 places individuals at high risk for developing Alzheimer disease. Yet, few studies have determined prevalence dementia and comorbidities among DS. <h3>Objective</h3> To determine aging-related in adult <h3>Design, Setting,...
To characterize the cognitive and neuropsychiatric symptoms of patients with behavioral variant frontotemporal dementia (bvFTD) over natural course disease.We examined initial subsequent neuropsychological test performance in a large cohort bvFTD (n = 204) across progressive stages disease as measured by Clinical Dementia Rating (CDR). We also compared impairments to those an age-matched Alzheimer (AD) 674).At earliest stage (CDR 0.5), had profound disturbances, insensitivity errors, slower...
The coronavirus (COVID-19) pandemic is still evolving, causing hundreds of millions infections around the world. long-term sequelae COVID-19 and neurologic syndromes post COVID remain poorly understood. present study aims to characterize cognitive performance in patients experiencing symptoms post-COVID infection. Patients evaluated at a clinic Northern Israel who endorsed were referred for consultation. work-up included detailed medical history, symptom inventory, neurological examination,...