A5044296441- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Pain Management
- Polyomavirus and related diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Anesthesia and Sedative Agents
- Tumors and Oncological Cases
- Transplantation: Methods and Outcomes
- Clinical Nutrition and Gastroenterology
- Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations and Hemangiomas
- Immunotherapy and Immune Responses
- Pediatric Hepatobiliary Diseases and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Eosinophilic Disorders and Syndromes
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
Stanford Medicine
1995-2023
Stanford University
2013-2022
University of Pittsburgh
2008-2020
Magee-Womens Hospital
1985-2019
Barro Colorado Island
2016-2019
Alberta Bible College
2019
Children's Hospital of Pittsburgh
2007-2018
Pain and Rehabilitation Medicine
2017-2018
University of Pittsburgh Medical Center
1988-2018
Palo Alto Institute
2018
Twenty cases of Epstein-Barr virus (EBV)-associated lymphoproliferative syndrome (LPS), defined by the presence EBV nuclear antigen and/or DNA in tissues, were diagnosed 1467 transplant recipients Pittsburgh from 1981–1985. The frequency occurrence pediatric was 4% (10/253), while adults it 0.8% (10/1214) (P < .0005). LPS declined after 1983 coincidental with introduction cyclosporine monitoring. However there no apparent decline children. We describe these ten and one additional case a...
Epstein-Barr virus (EBV) has been associated with nasopharyngeal carcinoma, some lymphomas, and lymphoproliferative disease after organ transplantation. Many tumors that occur transplantation are clonal, a property classifies them as neoplastic. Clonality can be determined by analysis of the extrachromosomal circular DNA episomes produced EBV infection.We describe three young children in whom smooth-muscle developed 18 months to 5 1/2 years liver immunosuppression. We examined microscopy...
A sulfated glycoprotein, entactin, of apparent molec- ular weight 158,000 has been isolated from an extracel- lular basement membrane-like matrix.This matrix is elaborated in cell culture by a mouse endodermal line.Antibodies prepared rabbits against this sul- fated glycoprotein react with and rat membranes variety tissues.These antibodies also specific manner discrete component kidney glomeruli.The electrophoretic mobility identical to that entactin.The antigen, as shown immunoelectron...
We studied the malignant lymphomas that developed in patients with Sjögren's syndrome and antecedent benign salivary-gland lesions to determine their cellular characteristics. used an immunoperoxidase technic identified intracellular gamma, alpha mu heavy chains kappa lambda light chains. In six of nine patients, were composed cells containing intracytoplasmic immunoglobulin was exclusively IgMK. The lymphoepithelial preceding these tumors consisted approximately equal numbers lymphoid...
Abstract Lymphopenia and lymphoid depletion occur in adults dying of sepsis. Prolactin increases Bcl-2 expression, suppresses stress-induced lymphocyte apoptosis, improves survival from experimental We hypothesized that prolonged lymphopenia, depletion, hypoprolactinemia children with sepsis multiple organ failure (MOF). Fifty-eight critically ill 55 without MOF admitted to a university hospital pediatric intensive care unit were enrolled prospective, longitudinal, observational clinical...
<b><i><i>Objective:</i></i></b> To evaluate the production rate of CSF in patients with differing disease states. <b><i><i>Methods:</i></i></b> The authors measured three groups patients: five PD below age 60 (aged 51 ± 4 years, mean SD), nine over 69 6 and seven dementia Alzheimer’s type (AD) 72 9 SD). This method, based on Masserman technique, employs ventricular rather than a lumbar access to space. Furthermore, volume removed during procedure is only 3 mL 10 mL....
Four small round cell malignant tumors of bone occurring in children are described. There was no catecholamine secretion and the clinical, radiologic, biopsy diagnosis each Ewing's sarcoma. Glycogen sparse both on imprints tissue sections. The tumors, when extensively sampled, had areas a lobular growth pattern Homer Wright rosettes. rosettes were always focal varied complexity from case to case; they rudimentary one instance markedly fibrillar most obvious instance. Neuron-specific enolase...
Epstein-Barr virus (EBV)—associated post-transplantation lymphoproliferative disease (PTLD) develops in 1 to 10 percent of transplant recipients, whom it can be treated by a reduction the level immunosuppression. We postulated that tissue expression small RNA transcribed EBER-1 gene during latent EBV infection would identify patients at risk for PTLD.
Central nervous system Langerhans cell histiocytosis (CNS-LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH-ND) of unknown etiology. The goal this study was to define the mechanisms pathogenesis that drive CNS-LCH.Cerebrospinal fluid (CSF) biomarkers including CSF proteins and extracellular BRAFV600E DNA were analyzed in from patients with CNS-LCH compared tumors other conditions. Additionally, presence tested peripheral mononuclear blood cells (PBMCs)...
This study was designed to evaluate intrathecal (IT) sufentanil for labor analgesia with respect sensory changes, side effects, and fetal heart rate (FHR) changes. In Phase I of the study, data regarding duration hemodynamic changes were obtained retrospectively from anesthetic records 90 patients who had received IT sufentanil, 10 micrograms in 1 mL saline, during active labor. II, an additional 18 parturients similar treatment studied prospectively document sensory, motor, as well...
<h2>Abstract</h2> Our aim was to analyze the clinical course and outcome of patients with graft vs. host disease (GVHD) after intestinal transplantation (ITx). All receiving ITx between May, 1990 December, 2003 were retrospectively reviewed for evidence GVHD. Two hundred fifty underwent during study period. Graft suspected clinically in 23 on basis presentation such as skin rash, ulceration oral mucosa, diarrhea, lymphadenopathy, or native liver dysfunction. Fourteen (eight children six...
Langerin is a recently identified lectin for which antibodies can be used as immunohistochemical markers of Langerhans cells (LCs). We describe the distribution staining in autopsy pediatric tissues, dermatopathic and other reactive lymph nodes, childhood histiocytic lesions using 12D6 antibody (Novocastra). also correlate CD1a (antibody O1O) to these factors. on epidermal LCs has coarsely granular cell membrane cytoplasmic pattern that always associated with expression. All 6 skin samples...
Although tumors are a known complication of von Recklinghansen's neurofibromatosis (NF), they often develop after the second decade and their characteristics in pediatric population unclear. To define frequency distribution tumor types children with NF, authors reviewed experience at Children's Hospital Pittsburgh between 1953 1984. During that time, 121 younger than 18 years documented NF were seen. Three patients (2.5%) developed locally extensive, unresectable sarcomas, two which clearly...
Mouse embryonal carcinoma F9 cells were exposed to retinoic acid and dibutyryl cyclic AMP. The treated synthesized secreted into the culture medium basal lamina components, laminin (GP-1 GP-2) entactin. time course of secretion components was examined by electron microscopic immunochemical procedures. induction resulted in major morphological changes deposition both entactin at cell surface junctions. Intracellular deposits could be localized endoplasmic reticulum membrane-bound...