A5076663918- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Intestinal Malrotation and Obstruction Disorders
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Xenotransplantation and immune response
- Organ Donation and Transplantation
- Metabolism and Genetic Disorders
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Nutrition and Health in Aging
- Inflammatory Bowel Disease
- Diet and metabolism studies
Cleveland Clinic
2013-2023
Case Western Reserve University
2019
Cleveland Clinic Lerner College of Medicine
2018-2019
University of Pittsburgh Medical Center
2006-2018
University of Pittsburgh
2005-2014
Columbia University Irving Medical Center
2014
Chinese University of Hong Kong
2014
University of Hong Kong
2014
UPMC Presbyterian
1992-2013
Presbyterian Hospital
2013
To evaluate the long-term survival outcomes of a large cohort liver transplant recipients and to identify static changing factors that influenced these over time.Liver transplantation has been accepted as therapeutic option for patients with end-stage disease since 1983, continual improvements in patient result advances immunosuppression medical management, technical achievements, procurement preservation. Although many reports, including registry data, have delineated short-term influence...
The intestine has been more difficult to transplant than other solid organs. We analyzed registry data determine the scope and success of transplantation in current era.All known intestinal-transplant programs participated. Patient- graft-survival estimates were obtained using Kaplan-Meier product limit method with Wilcoxon statistic.Sixty-one provided on 989 grafts 923 patients. Four patients lost follow-up. short-gut syndrome was most common primary indication for transplantation....
The Registry has gathered information on intestine transplantation (IT) since 1985. During this time, individual centers have reported progress but small case volumes potentially limit the generalizability of information. present study was undertaken to examine recent global IT activity. Activity assessed with descriptive statistics, Kaplan–Meier survival curves and a multiple variable analysis. Eighty-two programs 2887 transplants in 2699 patients. Regional practices outcomes are now...
To assess the evolution of visceral transplantation in milieu surgical technical modifications, new immunosuppressive protocols, and other management strategies.With clinical feasibility intestinal multivisceral 1990, multifaceted innovative tactics were required to improve outcome increase procedural practicality.Divided into 3 eras, 453 patients received 500 transplants. The primary used immunosuppression was tacrolimus-steroid-only during Era I (5/90–5/94), adjunct induction with multiple...
Objective To assess the long-term efficacy of intestinal transplantation under tacrolimus-based immunosuppression and therapeutic benefit newly developed adjunct immunosuppressants management strategies. Summary Background Data With advent tacrolimus in 1990, intestine began to emerge as therapy for failure. However, a high risk rejection, with consequent need acute chronic high-dose immunosuppression, has inhibited its widespread application. Methods During an 11-year period, divided into...
Background. Alemtuzumab is being increasingly used for the prevention and/or treatment of acute allograft rejection in organ transplant recipients. We assessed risks infection in, to our knowledge, largest cohort and broadest range recipients yet reported have received alemtuzumab. Methods. All patients who alemtuzumab from September 2002 through March 2004, either as induction therapy at time transplantation or rejection, were evaluated development an opportunistic (OI) until death 12...
Under FK 506-based immunosuppression, the entire cadaver small bowel except for a few proximal and distal centimeters was translated to 17 randomly matched patients, of whom two had antigraft cytotoxic antibodies (positive cross-match). Eight patients received intestine only, eight in continuity with liver, one full multivisceral graft that included stomach, pancreas. One liver-intestine recipient died after an intestinal anastomotic leak, sepsis, graft-versus-host disease. The other 16 are...
Ramos, Hector C.; Reyes, Jorge; Abu-Elmagd, Kareem; Zeevi, Adriana; Reinsmoen, Nancy; Tzakis, Andreas; Demetris, Anthony J.; Fung, John Flynn, Bridget; McMichael, John; Ebert, Fred; Starzl, Thomas E. Author Information
To evaluate the incidence of posttransplant lymphoproliferative disease (PTLD) and risk factors impact this complication on survival outcomes in a large cohort liver transplant recipients at single institution.Liver transplantation has been accepted as therapeutic option for patients with end-stage since 1983, part due to availability reliance use nonspecifically directed immunosuppression. However, predicted subsequently verified 1968, an increased certain de novo malignancies observed,...
In Brief Objective: To assess long-term survival, graft function, and health-related quality of life (QOL) after visceral transplantation. Background: Despite continual improvement in early the therapeutic efficacy transplantation has yet to be defined. Methods: A prospective cross-sectional study was performed on 227 allograft recipients who survived beyond 5-year milestone. Clinical data were used outcome including function survival predictors. The socioeconomic milestones QOL measures...
Background. Histologic evaluation of small bowel allograft biopsies is important for the diagnosis acute rejection. However, a standard histologic schema to grade severity intestinal rejection not currently available. The primary goal this study was develop grading system Methods. We evaluated 3268 obtained from adult patients who underwent transplantation at University Pittsburgh Medical Center between 1990 and 1999. A proposed validated by retrospective correlation with clinical outcomes....
Despite improvement in early outcome, rejection particularly chronic allograft enteropathy continues to be a major barrier long-term visceral engraftment. The potential role of donor specific antibodies (DSA) was examined 194 primary adult recipients. All underwent complement-dependent lymphocytotoxic crossmatch (CDC-XM) with pre- and posttransplant solid phase HLA-DSA assay 156 (80%). Grafts were ABO-identical random HLA-match. Liver included 71 (37%) allografts. Immunosuppression...
TODO, SATORU; TZAKIS, ANDREAS G.; ABU-ELMAGD, KAREEM; REYES, JORGE; FUNG, JOHN J.; CASAVILLA, ADRIAN; NAKAMURA, KENJIRO; YAGIHASHI, ATSUHITO; JAIN, ASHOK; MURASE, ; IWAKI, YUICHI; DEMETRIS, ANTHONY THIEL, DAVID VAN; STARZL, THOMAS E. Author Information
The effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology donation after cardiac death (DCD) livers transplantation have not been addressed thoroughly represent objective this study. Ten (5 per group) with 60 minutes warm ischemia were preserved via cold storage (CS) or sanguineous NMP for 10 hours, then they reperfused 24 hours whole blood in an isolated system to simulate transplantation. In our experiment, arterial...