A5102936964- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Coronary Interventions and Diagnostics
- Pancreatic function and diabetes
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Pediatric Hepatobiliary Diseases and Treatments
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Simulation-Based Education in Healthcare
- Acute Myocardial Infarction Research
- Tissue Engineering and Regenerative Medicine
- Pancreatitis Pathology and Treatment
- Biomedical Ethics and Regulation
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Mental Health Research Topics
- Surgical Simulation and Training
- Venous Thromboembolism Diagnosis and Management
- Treatment of Major Depression
Ain Shams University
2021
Cleveland Clinic
2012-2020
Institut für Abfall, Abwasser, Site und Facility Management
2018
John Wiley & Sons (United States)
2018
Alexandria University
2017
Mazor Mental Health Center
2003
The effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology donation after cardiac death (DCD) livers transplantation have not been addressed thoroughly represent objective this study. Ten (5 per group) with 60 minutes warm ischemia were preserved via cold storage (CS) or sanguineous NMP for 10 hours, then they reperfused 24 hours whole blood in an isolated system to simulate transplantation. In our experiment, arterial...
Normothermic machine perfusion (NMP) is an emerging preservation modality that holds the potential to prevent injury associated with low temperature and promote organ repair follows ischemic cell damage. While several animal studies have showed its superiority over cold storage (CS), minimal in literature focused on safety, feasibility, reliability of this technology, which represent key factors implementation into clinical practice. The aim present study report safety performance data NMP...
The utilization of normothermic machine perfusion (NMP) may be an effective strategy to resuscitate livers from donation after circulatory death (DCD). There is no consensus regarding the efficacy different perfusates on graft and bile duct viability. aim this study was compare, in NMP porcine DCD model, preservation potential three perfusates. Twenty with 60 min warm ischemia were separated into four groups: cold storage (CS), Steen solution (Steen; XVIVO Perfusion Inc., Denver, CO), plus...
Normothermic machine perfusion (NMP) is an emerging technology to preserve liver allografts more effectively than cold storage (CS). However, little known about the effect of NMP on steatosis and markers indicative hepatic quality during NMP. To address these points, we perfused 10 discarded human livers with oxygenated for 24 hours after 4-6 CS. All had a variable degree at baseline. The perfusate consisted packed red blood cells fresh frozen plasma. Perfusate analysis showed increase in...
Introduction Normothermic machine perfusion (NMP) of the liver is a promising preservation modality that holds potential to better preserve and even repair marginal grafts. In spite several literature studies showing benefits NMP over cold storage, there paucity data regarding mechanisms involved in optimization microcirculation during these organs. We present our on impact different vasodilators DCD porcine livers preserved with NMP. Materials methods Livers from 15 female Yorkshire pigs...
Normothermic machine perfusion (NMP) has been introduced as a promising technology to preserve and possibly repair marginal liver grafts. The aim of this study was compare the effect temperature on preservation donation after cardiac death (DCD) grafts in an ex vivo model NMP (38.5°C) subnormothermic (SNMP, 21°C) with control group preserved by cold storage (CS, 4°C). Fifteen porcine livers 60 min warm ischemia were for 10 h NMP, SNMP or CS (n = 5/group). After phase all reperfused 24...
Purpose Ex vivo perfusion of marginal kidney grafts offers the chance to expand donor pool, but there is no current clinical standard for prolonged warm renal grafts. This exploratory pilot study seeks identify a stable ex model that can support low intravascular resistance and preserve histologic architecture in porcine donation after cardiac death (DCD) model. Methods 15 kidneys were preserved 1 3 settings: normothermic whole blood (NT-WB), Steen Solution ™ (XVIVO Perfusion) with...
Not enough is known about the propensity of individual negative symptoms to respond treatment and dynamics this change. We have previously shown that adding selective serotonin reuptake inhibitor fluvoxamine antipsychotics can improve symptoms, now provide data on response such treatment. examined items Schedule for Assessment Negative Symptoms patients participating in two published controlled studies comparing effect add-on placebo symptoms. Using a mixed regression model, we analysed item...
Abstract Background Routine thrombus aspiration during primary PCI does not improve clinical outcomes. Although recent guidelines for management of patient presented by ST-elevation myocardial infarction treated recommend routine use and ranking it as class III recommendation. However, there is remaining uncertainty about rule TA in group patients STEMI their initial coronary angiogram shows large burden a logical rationale greater benefit, still, are no clear this patients; the aim study to...
Chronic pancreatitis (CP) is a severely disabling disorder with potential detrimental effects on quality of life, gut function, and glucose homeostasis. Disease progression often results in irreversible morphological functional abnormalities development chronic pain, mechanical obstruction, pancreatic insufficiency. Along comprehensive medical management, the concept total pancreatectomy islet autotransplantation (TP-AIT) was introduced 40 years ago for patients intractable pain preserved...
Introduction: In this study we investigated the ability of ex-vivo NMP to prevent primary graft non function severely injured DCD livers (WI=60 minutes) and promote biliary epithelium regeneration. Methods: Four porcine exposed 1hr WI were preserved by for 7hrs with whole blood as perfusate, then transplanted (DCD group). Two without directly a control group. Results: All 6 recipients presented excellent early function, extubated after surgery normal kidney function. 2/4 survived more than 5...
Introduction Hypothermic machine perfusion (HMP) represents the standard of care for preservation DCD kidneys. However, during HMP kidneys remain O2 deprived and cold temperatures are injurious. Ex-vivo normothermic (NMP) is an emerging technology given that providing graft with nutrients at physiologic can prevent both hypoxia. The aim this study to describe our initial results ex-vivo NMP in a porcine model using acellular plasma-like perfusate (Steen solution, SS). Methods Six underwent...
Introduction: Chronic pancreatitis is a debilitating disease that can lead to recurrent pain, malnutrition and pancreatic insufficiency. Total pancreatectomy with autologous islet transplantation (AIT) represents valid surgical option for both pain glycemic control. The liver the most common organ where cells are infused after processing. We present here an unusual case of total autoislet cell in patient prior (LT). Case: developed parenteral nutrition (TPN) dependent intestinal failure at...