A5080166750- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ and Tissue Transplantation Research
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Surgery and Complications
- Nutrition and Health in Aging
- Renal Transplantation Outcomes and Treatments
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Diet and metabolism studies
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Organ Donation and Transplantation
- Enhanced Recovery After Surgery
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Childhood Cancer Survivors' Quality of Life
- Transplantation: Methods and Outcomes
- Infant Nutrition and Health
- Liver Diseases and Immunity
Icahn School of Medicine at Mount Sinai
2014-2025
Mount Sinai Hospital
2019-2025
Mount Sinai Hospital
2009-2024
Mount Sinai Medical Center
2012-2024
Mount Sinai Hospital
2007-2022
Massachusetts General Hospital
2018
Merck (Japan)
2016
Fordham University
2009
Park Terrace Care Center
2007
Lurie Children's Hospital
2005-2006
The Registry has gathered information on intestine transplantation (IT) since 1985. During this time, individual centers have reported progress but small case volumes potentially limit the generalizability of information. present study was undertaken to examine recent global IT activity. Activity assessed with descriptive statistics, Kaplan–Meier survival curves and a multiple variable analysis. Eighty-two programs 2887 transplants in 2699 patients. Regional practices outcomes are now...
The goal was to improve immunosuppressant adherence for pediatric patients with orthotopic liver transplants by using text messaging (TM).A prospective study of sending TM reminders the primary medication administrator (patient or caregiver) transplant recipients performed. Patient records were reviewed, comparing year before and study. SD serum tacrolimus levels used as an indicator adherence.Forty-one provided consent. median age 15 years (range: 1-27 years), at time transplantation 2 4...
To determine if growth hormone (GH) and glutamine (Gln) might allow for a reduction in parenteral nutrition (PN) individuals with short bowel syndrome.
In Brief Objective: The goals of this study were to describe the clinical and anatomic features infants undergoing Kasai portoenterostomy (KPE) for biliary atresia (BA) examine associations between these parameters outcomes. Methods: Infants enrolled in prospective Childhood Liver Disease Research Education Network, who underwent KPE studied. Patients a blinded, interventional trial excluded from survival analysis. Primary endpoints successful surgical drainage (total bilirubin less than 2...
Introduction. Abdominal wall closure management has become an important challenge during recipient candidate selection, at the time of donor to matching and planning surgical procedure for intestinal or multiorgan transplantation. Different strategies have been proposed overcome lack abdominal domain: reduce graft size increase domain. Based on recent concept using acellular dermis matrix (Alloderm) availability tissues from same organ donor, we conceived idea fascia rectus muscle (FoRM) as...
Background: In phase III clinical studies, treatment with teduglutide was associated clinically meaningful reductions (≥20% from baseline) in parenteral support (PS; nutrition and/or intravenous fluids) requirements adult patients intestinal failure short bowel syndrome (SBS‐IF). This analysis reports characteristics of who achieved complete independence PS during treatment. Materials and Methods: Post hoc 0.05 mg/kg/d. Data were pooled 5 trials (2 placebo‐controlled [NCT00081458...
Abstract Background Patients with intestinal failure associated short bowel syndrome (SBS–IF) require parenteral support (PS) to maintain fluid balance or nutrition. Teduglutide (TED) reduced PS requirements in patients SBS–IF the randomized, placebo (PBO)‐controlled STEPS study (NCT00798967) and its 2‐year, open‐label extension, STEPS‐2 (NCT00930644). Methods STEPS‐3 (NCT01560403), a 1‐year, extension who completed STEPS‐2, further monitored safety efficacy of TED (0.05 mg/kg/day). Baseline...
To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 familial intrahepatic cholestasis‐1 (FIC1), 18 bile salt export pump (BSEP) disease, and 4 others low γ‐glutamyl transpeptidase disease (levels <100 U/L), were identified across 14 Childhood Liver Disease Research Network (ChiLDReN) centers. Data collected retrospectively from individuals who collectively had 39 partial external...
The most common application of small bowel transplantation is for the patient with parenteral nutrition-induced liver failure. In this setting, intestine transplanted simultaneously liver. We identified three technical problems that we believe contributed to complications in our first eight patients. First, pancreaticoduodenectomy was challenging infant donor. Second, graft prone volvulus around skeletonized donor portal vein. Third, pediatric recipient, use Roux-en-Y biliary reconstruction...
Abstract The purpose of this study was to examine the safety, feasibility, acceptability, and preliminary efficacy a cross‐age peer mentoring program created improve adherence psychosocial outcomes for pediatric liver transplant recipients. Twenty‐two participants were assigned “mentor now” or later” waitlist control group. Tacrolimus SD , validated measure adherence, assessed six months pre‐ post‐intervention both groups. Self‐report measures self‐management HRQOL completed at recruitment...
In multiple clinical studies, teduglutide reduced parenteral support (PS) with a consistent safety profile in adults short bowel syndrome-associated intestinal failure (SBS-IF). The objective of this study was to assess adverse events (AEs) from pooled data set.Safety four prospective trials patients SBS-IF were assimilated. AEs evaluated patient groups based on treatment received each and populations stratified create distinct subgroups aetiology, anatomy baseline PS volume...
Abstract Background Rare and nutritionally complex diseases, like chronic intestinal failure (CIF), are not encountered regularly by clinicians. Specialized centers with experience in relatively sparse, leading many patients to rely on local Previously published reports demonstrated lack of knowledge among gastroenterologists the United States, Europe, Kingdom. This study aims evaluate a cohort registered dietitians. Methods A validated, 20‐question survey CIF covering four key domains was...
The purpose of the present study was to describe and compare mastery health care management in adolescent (aged 14-17 years) young adult recipients a liver transplant (age ≥ 18 expected transfer from pediatric settings.Fifty-two completed Developmentally Based Skills Checklist, which asks how often patients independently engage specific skills.Overall, reported greater than adolescents. However, less half adults surveyed consistently managing their disease independently, making own...
Abstract Background Children have increased prevalence of food allergy ( FA ) and eosinophilic gastrointestinal disease EGID following liver transplantation. The aim this study was to identify related risk factors. Methods Chart review pediatric transplant LT recipients with de novo and/or post‐ non‐allergic controls. Results We identified 30 (8.5%) children among 352 recipients. Median age at 0.9 inter‐quartile range IQR 0.6–2.0) years. developed a median 1.0 0.5–8.2) yr manifested symptoms...