A5043694977- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Abdominal Surgery and Complications
- Magnesium in Health and Disease
- Microscopic Colitis
- Metabolism and Genetic Disorders
- Gut microbiota and health
- Child Nutrition and Feeding Issues
- Parathyroid Disorders and Treatments
- Enhanced Recovery After Surgery
- Obesity and Health Practices
- Gastrointestinal motility and disorders
- Dietetics, Nutrition, and Education
- Intestinal Malrotation and Obstruction Disorders
- Intestinal and Peritoneal Adhesions
- Pancreatitis Pathology and Treatment
- Central Venous Catheters and Hemodialysis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Childhood Cancer Survivors' Quality of Life
- Esophageal and GI Pathology
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical studies and practices
Cleveland Clinic
2002-2022
Vanderbilt University Medical Center
2011-2020
Vanderbilt University
2013-2020
Mayo Clinic in Arizona
2020
American Society for Parenteral and Enteral Nutrition
2020
University of Illinois Chicago
2020
Icahn School of Medicine at Mount Sinai
2020
University of New Mexico
2020
Rhode Island Hospital
2020
Providence College
2020
Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics. This randomized clinical trial was designed to compare effectiveness and side effects ciprofloxacin metronidazole treating pouchitis. Acute defined as a score 7 or higher on 18-point Pouchitis Disease Activity Index (PDAI) symptom duration 4 weeks less. Sixteen patients were 2-week course 1,000 mg/d (n = 7) 20 mg/kg/d 9). Clinical...
Parenteral administration of long-chain triglyceride emulsions has been shown to have deleterious effects on reticuloendothelial system function in animal models. It is unknown whether this interference occurs humans with clinically relevant doses intravenous fat. Two studies were done. Eighteen patients prospectively enrolled for study. Patients received full feeding by continuous total parenteral nutrition (amino acids 1.5 g/kg/day and dextrose 4.5 g/kg/day) 33.1 kcal/kg/day. Forty-three %...
Abstract Background Magnesium plays an essential role in the synthesis and metabolism of vitamin D magnesium supplementation substantially reversed resistance to treatment patients with magnesium-dependent vitamin-D-resistant rickets. We hypothesized that dietary alone, particularly its interaction intake, contributes serum 25-hydroxyvitamin (25(OH)D) levels, associations between 25(OH)D risk mortality may be modified by intake level. Methods tested these novel hypotheses utilizing data from...
The currently available, standard soybean oil (SO)-based intravenous fat emulsions (IVFEs) meet the needs of most parenteral nutrition (PN) patients. There are alternative oil-based emulsions, such as medium-chain triglycerides (MCTs), olive oils (OOs), and fish (FOs), that, based on extensive usage in Europe, have an equivalent safety profile to SO. These IVFEs metabolized via different pathways, which may lead less proinflammatory effects immune suppression. not available United States....
Abstract The purpose of this study is to evaluate similarities and differences in gut bacterial measurements stability the microbial communities three different types samples that could be used assess niches microbiome: rectal swab, stool, normal mucosa samples. In swab-stool comparisons, there were substantial taxa with some varying largely by sample type (e.g. Thermaceae), inter-individual subject variation Desulfovibrionaceae), or both participant Enterobacteriaceae). Comparing all...
Clinical studies showed teduglutide to increase urine production and reduce need for parenteral support volume in patients with short bowel syndrome (SBS) intestinal failure, increasing wet weight absorption reducing diarrhea. However, the effects of on vary among patients. We performed a post hoc analysis phase III placebo-controlled study identify characteristics whom has largest response.We collected data from 85 SBS according European Society Nutrition Metabolism classification system,...
Inflammatory bowel disease (IBD) is associated with altered body composition, such as low muscle mass, which affects clinical outcomes. Body composition changes in overweight patients IBD are less understood. The study aim was to determine the prevalence of sarcopenic and obese a cohort starting new anti-tumor necrosis factor-α therapy examine differences response.This retrospective review medication that had computed tomography within 3 months initiation. L3 vertebral slice used for...
Previous study demonstrated that patients who received total parenteral nutrition (TPN) with standard intermittent infusion of long chain triglyceride (LCT) at 0.13 g kg −1 hr over 10 for each three days showed a significant decline in 99 Tc‐sulfur colloid (TSC) clearance rate by the reticuloendothelial system (RES). The present studies evaluated eight same lipid dose LCT infused continuously as three‐in‐one admixture, and another nine receiving amount fat medium (MCT)/LCT (75%/25%) emulsion...
The 1 American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) is a professional society of physicians, nurses, dietitians, pharmacists, allied health professionals researchers dedicated to assuring that every patient receives optimal nutrition care. A.
Abstract Background Patients with intestinal failure associated short bowel syndrome (SBS–IF) require parenteral support (PS) to maintain fluid balance or nutrition. Teduglutide (TED) reduced PS requirements in patients SBS–IF the randomized, placebo (PBO)‐controlled STEPS study (NCT00798967) and its 2‐year, open‐label extension, STEPS‐2 (NCT00930644). Methods STEPS‐3 (NCT01560403), a 1‐year, extension who completed STEPS‐2, further monitored safety efficacy of TED (0.05 mg/kg/day). Baseline...
Background: Abnormal liver enzymes and endstage disease are reported to occur in 25%–100% 15%–40% of adult patients receiving long‐term parenteral nutrition (PN), respectively. The purpose this historic cohort study was investigate the incidence possible factors leading development our large home PN population. Methods: All on for at least 6 months from July 1991 through June 2002 were eligible. Patients excluded if they had active malignancy, underlying disease, or exposure a hepatotoxin....
Short bowel syndrome–associated intestinal failure (SBS‐IF) as a consequence of extensive surgical resection the gastrointestinal (GI) tract results in chronic reduction absorption. The ensuing malabsorption conventional diet with associated diarrhea and weight loss dependency on parenteral nutrition and/or intravenous fluids (PN/IV). A natural compensatory process adaptation occurs years after body responds to lack sufficient functional nutrient‐processing surface area. adaptive improves...
In multiple clinical studies, teduglutide reduced parenteral support (PS) with a consistent safety profile in adults short bowel syndrome-associated intestinal failure (SBS-IF). The objective of this study was to assess adverse events (AEs) from pooled data set.Safety four prospective trials patients SBS-IF were assimilated. AEs evaluated patient groups based on treatment received each and populations stratified create distinct subgroups aetiology, anatomy baseline PS volume...
Abstract The gut microbiota plays an important role in human health and disease. Stool, rectal swab mucosal tissue samples have been used individual studies to survey the microbial community but consequences of using these different sample types are not completely understood. In this study, we report differences stool, communities with shotgun metagenome sequencing 1397 from 240 participants. taxonomic composition stool was distinct, less each other than samples. Functional profile between...
Abstract Background Teduglutide response, in terms of parenteral support (PS) volume reduction, is associated with specific disease characteristics among adults short bowel syndrome–associated intestinal failure (SBS‐IF). Whether these associations apply to PS weaning teduglutide unknown. Methods Adults SBS‐IF treated the phase III STEPS study and open‐label extensions STEPS‐2 STEPS‐3 were included analysis. Patients required ≥ 3 times weekly for 12 months at enrollment. The population was...
Venous thrombosis is a potential postplacement complication of central venous access device (VAD). Improper catheter tip position predisposing factor, especially when the used to administer parenteral nutrition (PN). American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) guidelines recommend that VAD PN be placed with its in superior vena cava (SVC) adjacent right atrium (RA). The purpose this study determine prevalence improper factors associated malpositioning.All adult...
Background : An electromagnetic tube placement device (ETPD) monitors tip position of feeding tubes (FT) during in the digestive tract. It helps to avoid airway misplacement and permits positioning into small bowel (SB). This study compares overall agreement between FT location as determined by an ETPD vs abdominal radiograph kidneys, ureter, bladder (KUB). Methods Using ETPD, A nurse placed postpyloric FTs ICU patients. We included all patients whom was used for placement. Data were...