A5024781925- Nutrition and Health in Aging
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Body Composition Measurement Techniques
- Child Nutrition and Feeding Issues
- HIV-related health complications and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
- Gastroesophageal reflux and treatments
- Bariatric Surgery and Outcomes
- Geriatric Care and Nursing Homes
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Eosinophilic Esophagitis
- Food Security and Health in Diverse Populations
- Dietetics, Nutrition, and Education
- Helicobacter pylori-related gastroenterology studies
- Child Nutrition and Water Access
- Obesity and Health Practices
- Thermoregulation and physiological responses
Vanderbilt University Medical Center
2015-2025
VA Tennessee Valley Healthcare System
2018-2025
Vanderbilt University
2010-2023
Nashville Oncology Associates
2018
Florida International University
2000-2003
University of Miami
1993
We aimed to determine changes in body mass and composition relation energy balance, inflammatory state, physical function before after concurrent chemoradiation (CCR).Seventeen patients with stage III IVa head neck cancer, aged 58.9 +/- 5.4 years, who had completed a 9-week regimen of low-dose induction chemotherapy came the General Clinical Research Center pre- post-CCR for measurement by dual-energy X-ray absorptiometry, resting expenditure (REE) indirect calorimetry, performance (by...
Inflammatory bowel disease (IBD) is associated with altered body composition, such as low muscle mass, which affects clinical outcomes. Body composition changes in overweight patients IBD are less understood. The study aim was to determine the prevalence of sarcopenic and obese a cohort starting new anti-tumor necrosis factor-α therapy examine differences response.This retrospective review medication that had computed tomography within 3 months initiation. L3 vertebral slice used for...
To investigate the hypothesis that weight loss with glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide alone would lead to a greater reduction in proportion of fat lean tissue mass when compared caloric restriction (CR) alone, as well treatment sitagliptin, dipeptidyl peptidase-4 (DPP-4) inhibitor, also enhances GLP-1 activity - determine independent effects each treatment.
We designed a prospective randomized, controlled pilot trial to investigate the effects of an enriched oral nutrition supplement on body composition and clinical outcomes following radical cystectomy.A total 61 patients were randomized or multivitamin multimineral twice daily during 8-week perioperative period. Body was determined by analyzing abdominal computerized tomography images at L3 vertebra. Sarcopenia defined as skeletal muscle index less than 55 cm/m in males 39 females. The...
Reducing dietary energy density has proven to be an effective strategy reduce intakes and promote weight control. This effect appears most robust when a low dense preload is consumed before meals. Yet, much discussion continues regarding the optimal form of preload. The purpose present study was compare effects solid (grapefruit), liquid (grapefruit juice) water prior breakfast, lunch dinner in context caloric restriction.Eighty-five obese adults (BMI 30-39.9) were randomly assigned (127 g)...
Metabolic effects of glucagon-like peptide 1 (GLP-1) receptor agonists are confounded by weight loss and not fully recapitulated increasing endogenous GLP-1. We tested the hypothesis that GLP-1 (GLP-1R) exert loss–independent, GLP-1R–dependent differ from Individuals with obesity prediabetes were randomized to receive for 14 weeks GLP-1R agonist liraglutide, a hypocaloric diet, or dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin. The antagonist exendin(9-39) placebo administered in...
The prevalence of metabolic syndrome has been increasing in young adults, concomitant with the occurrence increased abdominal adiposity. We previously reported that consuming tree nuts, as replacement for typical high-carbohydrate snacks, reduces visceral fat and waist circumference adults who have one or more risk factors. aimed to investigate effects nuts snack consumption on plasma adipose tissue fatty acid profiles along changes expression genes involved thermogenesis, glycemia,...
Background: Evidence from animal models suggests that redox homeostasis (the balance between oxidative stressors and antioxidants) vascular health are important in the pathogenesis of sensorineural hearing loss (SNHL) dietary nutrients have roles these processes could influence susceptibility to SNHL. Purpose: To examine associations total nutrient intakes auditory function outcomes an older human population. Research Design: Descriptive characteristics data food frequency questionnaires...
Prior research has indicated that greater dietary variety in a single eating episode increases caloric intake, contributing to weight gain and obesity. This study presents novel conceptual framework for investigating across the entire diet according time frame (cumulative vs. daily), aggregation level (overall episode-specific), categorization (individual foods food groups). is used assess how naturally occurring relates loss among overweight/obese women enrolled 16-week trial achieve loss....
Patients with achalasia present dysphagia, regurgitation, and varying degrees of weight loss. However, despite it being a disorder the lower esophageal sphincter functional obstruction in all patients, is unclear why certain patients lose significantly more compared to others. The aims this study are assess demographic, clinical, manometric characteristics large cohort determine potential correlates loss population. diagnosis referred our center between 2009 2016 were evaluated. Demographic...
To test the hypothesis that glucagon-like peptide-1 receptor (GLP-1R) agonists have beneficial effects on vascular endothelial function, fibrinolysis and inflammation through weight loss-independent mechanisms.
INTRODUCTION: This is the first randomized controlled diet intervention trial to investigate both amount and type of carbohydrate on symptomatic gastroesophageal reflux disease (GERD). METHODS: Ninety-eight veterans with GERD were randomly assigned high total/high simple, total/low low or simple for 9 weeks. The primary outcomes esophageal acid exposure time (AET) total number episodes derived from 24-hour ambulatory pH monitoring. Secondary symptoms rated using Gastroesophageal Reflux...
•The prevalence of sarcopenia is high among patients with cirrhosis.•Despite liver transplantation, in most never resolves afterwards.•Skeletal muscle mass worsens the years following transplant worsening being pronounced first year.•The degree exposure to calcineurin inhibitors was not associated evolution post-LT.•There no evidence that post—transplant mortality this study. Background & AimsSarcopenia has significant burden cirrhosis and been shown worsen short-term post-liver...
Obesity is a threat to public health worldwide primarily due the comorbidities related visceral adiposity, inflammation, and insulin resistance that increase risk for type 2 diabetes cardiovascular disease. The translational research portfolio originally described these factors was significantly enhanced by imaging techniques, such as dual-energy X-ray absorptiometry (DEXA), computed tomography (CT), magnetic resonance (MRI). In this article, we briefly review important contributions of...
Improved understanding of how depot-specific adipose tissue mass predisposes to obesity-related comorbidities could yield new insights into the pathogenesis and treatment obesity as well metabolic benefits weight loss. We hypothesized that three-dimensional (3D) contiguous "fat-water" MR imaging (FWMRI) covering majority a whole-body field view (FOV) acquired at 3 Tesla (3T) coupled with automated segmentation quantification amount, type, distribution lean soft would show great promise in...
Introduction Plasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been associated with risk type 2 diabetes (T2D) and atherosclerosis. However, little is known about relationship 2-AAA to other cardiometabolic markers in pre-disease states, or setting comorbid disease. Methods We measured circulating using two methods 1) a sample 261 healthy individuals (2-AAA Study), 2) 134 persons comprising 110 treated HIV, without T2D, population at high metabolic disease cardiovascular...