A5056558330- Gut microbiota and health
- Diet and metabolism studies
- Birth, Development, and Health
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Neonatal Respiratory Health Research
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Probiotics and Fermented Foods
- Health, Environment, Cognitive Aging
- Tryptophan and brain disorders
- Adolescent and Pediatric Healthcare
- Dietary Effects on Health
- Climate Change and Health Impacts
- Colorectal Cancer Screening and Detection
North Carolina Agricultural and Technical State University
2025
Children's Hospital of Los Angeles
2019-2024
Johns Hopkins University
2024
University of Illinois Urbana-Champaign
2023
University of Southern California
2017-2021
University of North Carolina at Charlotte
2016-2020
Southern California University for Professional Studies
2020
Keck Hospital of USC
2020
Despite recent decreases in the cost of sequencing, shotgun metagenome sequencing remains more expensive compared with 16S rRNA amplicon sequencing. Methods have been developed to predict functional profiles microbial communities based on their taxonomic composition. In this study, we evaluated performance three commonly used prediction tools (PICRUSt, PICRUSt2, and Tax4Fun) by comparing significance differential abundance predicted gene those from across different environments.We selected 7...
Animal work indicates exposure to air pollutants may alter the composition of gut microbiota. This study examined relationships between and microbiome in young adults residing Southern California. Our results demonstrate significant associations using whole-genome sequencing. Higher 24-hour O3 was associated with lower Shannon diversity index, higher Bacteroides caecimuris, multiple gene pathways, including L-ornithine de novo biosynthesis as well pantothenate coenzyme A I. Among other...
Infant cognitive development is influenced by maternal factors that range from obesity to early feeding and breast milk composition. Animal studies suggest a role for human oligosaccharide (HMO), 2'-fucosyllactose (2'FL), on learning memory, yet no have examined its impact infant relative other HMOs factors.To determine the of 2'FL at 24 months age frequency.Hispanic mother-infant pairs (N = 50) were recruited across spectrum pre-pregnancy BMI. Breast was collected 1 6 months, feedings/day...
Abstract The purpose of this study is to evaluate similarities and differences in gut bacterial measurements stability the microbial communities three different types samples that could be used assess niches microbiome: rectal swab, stool, normal mucosa samples. In swab-stool comparisons, there were substantial taxa with some varying largely by sample type (e.g. Thermaceae), inter-individual subject variation Desulfovibrionaceae), or both participant Enterobacteriaceae). Comparing all...
Background A western high fat, carbohydrate diet has been shown to be associated with decreased gut bacterial diversity and reductions in beneficial bacteria. This bacteria dysbiosis could develop early life contribute chronic disease risk such as obesity, type 2 diabetes non-alcoholic fatty liver disease.Objective To determine how dietary macronutrients are the relative abundance of healthy adolescents.Methods Fifty-two obese participants (12–19 years) from two studies, many who were...
Human milk oligosaccharides (HMOs) are complex glycans that highly abundant in human milk. While over 150 HMOs have been identified, it is unknown how individual change concentration 24 months of lactation.To understand HMO concentrations lactation.Breast samples were collected from participants a longitudinal cohort study Hispanic mother-infant pairs at 1, 6, 12, 18, and postpartum. Concentrations 19 the most measured using HPLC. Because parent ongoing not all finished time points yet,...
Abstract Emerging evidence highlights a critical relationship between gut microbiota and neurocognitive development. Excessive consumption of sugar other unhealthy dietary factors during early life developmental periods yields changes in the microbiome as well impairments. However, it is unclear whether these two outcomes are functionally connected. Here we explore excessive added sugars negatively impacts memory function via microbiome. Rats were given free access to sugar-sweetened...
Summary Background Numerous studies have shown that there are links between obesity, liver fat and the gut microbiome. However, mixed results on whether probiotics could impact microbiome and/or help to decrease obesity outcomes. Objective This study aimed determine a probiotic supplement (VSL#3 ® ) intervention altered microbiota hormones associated with appetite regulation. The secondary aim of this was VSL#3 body composition fibrosis. Methods We conducted double‐blind, randomized...
We aimed to determine if the newborn gut microbiota is an underlying determinant of early life growth trajectories. 132 Hispanic infants were recruited at 1-month postpartum. The infant microbiome was characterized using 16S rRNA amplicon sequencing. Rapid defined as a weight-for-age z-score (WAZ) change greater than 0.67 between birth and 12-months age. Measures included in WAZ, weight-for-length (WLZ), body mass index (BMI) z-scores from anthropometrics (weight, skinfold thickness). Of...
Monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (MT) and inflammation with ageing despite equivalent health status, lifelong diet environmental conditions. We evaluated colonic structural, microbiomic functional changes in old female vervet monkeys (Chlorocebus aethiops sabeus) how age-related leaky gut alters responses to Western diet. additionally assessed serum bovine immunoglobulin therapy lower MT burden....
Abstract Background Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors childhood adolescence. However, few studies have assessed changes infant body composition or multiple pollutant exposures. Therefore, the objective this study was examine relationships between prenatal residential AAP growth adiposity. Methods Residential (particulate matter...
Colonic diverticula are protrusions of the mucosa through weak areas colonic musculature. The etiology diverticulosis is poorly understood, but could be related to gut bacteria. Using mucosal biopsies from sigmoid colon 226 subjects with and 309 without during first-time screening colonoscopy, we assessed whether individuals incidental have alternations in adherent bacterial communities colon. We found little evidence substantial associations between microbial community among cases controls....
Growing evidence indicates that human milk oligosaccharides (HMOs) are important bioactive compounds enhance health and developmental outcomes in breastfed babies. Maternal dietary intake likely contributes to variation HMO composition, but studies identifying diet–HMO relationships few inconsistent. This study aimed investigate how the maternal of macronutrients micronutrients—specifically proteins, fats, vitamins, minerals—associated with HMOs at 1 month (n = 210), 6 months 131), 12...
Infant formula feeding, compared with human milk, has been associated development of a distinct infant gut microbiome, but no previous study examined effects added sugars. This work differences in microbiota among 91 Hispanic infants who consumed milk [at breast (BB) vs. pumped bottle (BP)] and 2 kinds [(traditional lactose-based (TF) lactose-reduced sugar (ASF)]. At 1 6 months, stool was collected to characterize microbiota. mothers completed 24-hour dietary recalls questionnaires determine...
The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain 6 months and associations varied by HMO secretor status.Participants were 157 Hispanic mother-infant pairs. Human samples collected month. Nineteen individual HMOs analyzed using high-performance liquid chromatography, status determined the presence 2'-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant measured months. Path analysis used test effects composition on...
Abstract Background Probiotics have been demonstrated to ameliorate clinical signs of gastrointestinal diseases in dogs various studies. However, the effect probiotics a healthy population, as well factors contributing individualized responses, remain largely unknown. This trial examined gut microbiota (GM) and health outcomes household after synbiotic (SN) supplementation containing inulin (a prebiotic). Healthy were randomized receive SN (50 mg/d 20 billion total CFU/d L. reuteri , P....
Summary Background Human milk oligosaccharides (HMOs) are naturally occurring glycans in human breast that act as prebiotics the infant gut. Prebiotics have been demonstrated to suppress appetite both adults and children. Therefore, HMOs may affect eating behaviour. Objective To determine if associated with behaviour Hispanic infants. Methods Cross‐sectional analysis of a prospective cohort mother‐infant dyads (1‐month, n = 157; 6‐months, 69). Breast samples were screened for 19 using high...
Summary Background It is unknown to what extent higher maternal blood pressure (BP) in early postpartum impacts the relationship between weight status and greater infant gain postpartum. Objective To evaluate mediating role of BP at 1 month on association over 6 months Methods Participants were 169 Hispanic mother‐infant pairs. Maternal body mass index (BMI) assessed Infant was measured calculate weight‐for‐age z scores (WAZ). Multiple linear regression models used for prediction, Sobel test...
Abstract Background Despite recent decreases in the cost of sequencing, shotgun metagenome sequencing remains more expensive compared with 16S rRNA amplicon sequencing. Methods have been developed to predict functional profiles microbial communities based on their taxonomic composition, and PICRUSt is most widely used these techniques. In this study, we evaluated performance by comparing significance differential abundance gene predicted those from across different environments. Results We...