Christopher J. Machle

ORCID: 0009-0004-1243-7901
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Infant Nutrition and Health
  • Obesity, Physical Activity, Diet
  • Liver Disease Diagnosis and Treatment
  • Diet, Metabolism, and Disease
  • Breastfeeding Practices and Influences
  • Birth, Development, and Health
  • Air Quality and Health Impacts
  • Health and Lifestyle Studies
  • Diet and metabolism studies
  • Neonatal Respiratory Health Research
  • Child Nutrition and Water Access
  • Gestational Diabetes Research and Management
  • Gut microbiota and health
  • Digestive system and related health

Children's Hospital of Los Angeles
2023-2025

University of Oregon
2024-2025

Childhood obesity disproportionately impacts marginalized and under-resourced communities, particularly Latinos. Although consumption of sugar-sweetened beverages juices (SSBJs) in infancy is linked to increased obesity, few early-life interventions have targeted SSBJ reduction. To determine the efficacy a culturally tailored home intervention for reducing intake risk Latino mothers infants. Mother-infant dyads (N = 210) were randomly assigned 1 3 2 years: 1) general health education...

10.1016/j.ajcnut.2024.11.009 article EN cc-by-nc-nd American Journal of Clinical Nutrition 2025-01-09

Growing evidence indicates that human milk oligosaccharides (HMOs) are important bioactive compounds enhance health and developmental outcomes in breastfed babies. Maternal dietary intake likely contributes to variation HMO composition, but studies identifying diet–HMO relationships few inconsistent. This study aimed investigate how the maternal of macronutrients micronutrients—specifically proteins, fats, vitamins, minerals—associated with HMOs at 1 month (n = 210), 6 months 131), 12...

10.3390/nu16121795 article EN Nutrients 2024-06-07

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common paediatric disease. Latinos have high MASLD risk due to 50% prevalence of GG genotype PNPLA3. Our primary aim was evaluate associations between dietary carbohydrates/sugars and stiffness in Latino adolescents with obesity. secondary examine effect modification by (a) PNPLA3 or (b) severity. Data were obtained from 114 obesity involved two prior studies. No seen group as a whole. In subjects PNPLA3, total...

10.1111/liv.15946 article EN Liver International 2024-04-18

Abstract Objective This study explores the impact of maternal pre‐pregnancy BMI on infant neurodevelopment at 24 months in low‐income Latino families. It also investigates whether diet mediates this relationship. Methods mother‐infant pairs ( n = 163) were enrolled 1 month post partum and followed for 2 years, with assessments 6‐month intervals. Maternal anthropometrics self‐reported baseline, child was assessed using Bayley Scales Infant Development. Diet quality infants measured Healthy...

10.1002/oby.24010 article EN Obesity 2024-04-10
Coming Soon ...