A5067954910- Breastfeeding Practices and Influences
- Infant Nutrition and Health
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Child Nutrition and Feeding Issues
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Nutritional Studies and Diet
- Air Quality and Health Impacts
- Gestational Diabetes Research and Management
- Eating Disorders and Behaviors
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Health, Environment, Cognitive Aging
- Virus-based gene therapy research
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- Human Health and Disease
- Regulation of Appetite and Obesity
- Bone health and osteoporosis research
- Pediatric health and respiratory diseases
- Climate Change and Health Impacts
- Infant Development and Preterm Care
Brigham and Women's Hospital
2022-2025
Harvard University
2022-2025
Children's Hospital of Los Angeles
2019-2022
University of Southern California
2017-2022
Mass General Brigham
2022
Keck Hospital of USC
2020
University of Georgia
2013-2017
University of Würzburg
1991
Infant cognitive development is influenced by maternal factors that range from obesity to early feeding and breast milk composition. Animal studies suggest a role for human oligosaccharide (HMO), 2'-fucosyllactose (2'FL), on learning memory, yet no have examined its impact infant relative other HMOs factors.To determine the of 2'FL at 24 months age frequency.Hispanic mother-infant pairs (N = 50) were recruited across spectrum pre-pregnancy BMI. Breast was collected 1 6 months, feedings/day...
Human milk oligosaccharides (HMOs) are complex glycans that highly abundant in human milk. While over 150 HMOs have been identified, it is unknown how individual change concentration 24 months of lactation.To understand HMO concentrations lactation.Breast samples were collected from participants a longitudinal cohort study Hispanic mother-infant pairs at 1, 6, 12, 18, and postpartum. Concentrations 19 the most measured using HPLC. Because parent ongoing not all finished time points yet,...
We aimed to determine if the newborn gut microbiota is an underlying determinant of early life growth trajectories. 132 Hispanic infants were recruited at 1-month postpartum. The infant microbiome was characterized using 16S rRNA amplicon sequencing. Rapid defined as a weight-for-age z-score (WAZ) change greater than 0.67 between birth and 12-months age. Measures included in WAZ, weight-for-length (WLZ), body mass index (BMI) z-scores from anthropometrics (weight, skinfold thickness). Of...
Epidemiological studies in adults have shown that exposure to ambient air pollution (AAP) is associated with the composition of adult gut microbiome, but these relationships not been examined infancy. We aimed determine if 6-month postnatal AAP was infant microbiota at 6 months age a cohort Latino mother-infant dyads from Southern California Mother's Milk Study (n = 103). estimated particulate matter (PM2.5 and PM10) nitrogen dioxide (NO2) birth 6-months based on residential address...
Abstract Background Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors childhood adolescence. However, few studies have assessed changes infant body composition or multiple pollutant exposures. Therefore, the objective this study was examine relationships between prenatal residential AAP growth adiposity. Methods Residential (particulate matter...
Childhood obesity disproportionately impacts marginalized and under-resourced communities, particularly Latinos. Although consumption of sugar-sweetened beverages juices (SSBJs) in infancy is linked to increased obesity, few early-life interventions have targeted SSBJ reduction. To determine the efficacy a culturally tailored home intervention for reducing intake risk Latino mothers infants. Mother-infant dyads (N = 210) were randomly assigned 1 3 2 years: 1) general health education...
While studies in rat pups suggest that early zinc exposure is critical for optimal brain structure and function, associations of prenatal intake with measures development infants are unknown. This study aimed to assess the maternal during pregnancy MRI tissue microstructure neurodevelopmental outcomes, as well determine whether mediated relationship between indices. Forty-one adolescent mothers were recruited a longitudinal pregnancy. Maternal was assessed third trimester using 24 h dietary...
This study determined the effects of consuming a high-fructose corn syrup (HFCS)-sweetened beverage on breast milk fructose, glucose, and lactose concentrations in lactating women. At six weeks postpartum, mothers (n = 41) were randomized to crossover consume commercially available HFCS-sweetened or artificially sweetened control beverage. each session, pumped complete expression every hour for consecutive hours. The baseline fasting 5.0 ± 1.3 µg/mL, 0.6 0.3 mg/mL, 6.8 1.6 g/dL,...
Infant formula feeding, compared with human milk, has been associated development of a distinct infant gut microbiome, but no previous study examined effects added sugars. This work differences in microbiota among 91 Hispanic infants who consumed milk [at breast (BB) vs. pumped bottle (BP)] and 2 kinds [(traditional lactose-based (TF) lactose-reduced sugar (ASF)]. At 1 6 months, stool was collected to characterize microbiota. mothers completed 24-hour dietary recalls questionnaires determine...
Animal studies have shown that human milk oligosaccharides (HMOs) are important in early brain development, yet their roles not been assessed humans. The purpose of this study was to determine the associations HMOs with MRI indices tissue microstructure and regional cerebral blood flow (rCBF) infants. Mother-infant pairs (N = 20) were recruited at 1 month postpartum. Milk assayed for concentrations 2'-fucosyllactose (2'FL), 3-fucosyllactose (3FL), 3'-sialyllactose (3'SL), 6'-sialyllactose...
Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant equivocal.Associations of Ad36 with total body adiposity inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).Fasting blood samples measured for presence Ad36-specific antibodies TNF-α, IL-6, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1). Fat mass fat-free soft tissue by...
The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain 6 months and associations varied by HMO secretor status.Participants were 157 Hispanic mother-infant pairs. Human samples collected month. Nineteen individual HMOs analyzed using high-performance liquid chromatography, status determined the presence 2'-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant measured months. Path analysis used test effects composition on...
Summary Background Human milk oligosaccharides (HMOs) are naturally occurring glycans in human breast that act as prebiotics the infant gut. Prebiotics have been demonstrated to suppress appetite both adults and children. Therefore, HMOs may affect eating behaviour. Objective To determine if associated with behaviour Hispanic infants. Methods Cross‐sectional analysis of a prospective cohort mother‐infant dyads (1‐month, n = 157; 6‐months, 69). Breast samples were screened for 19 using high...
Previous RCTs to prevent early rapid weight gain were conducted in predominantly White, well-educated, middle-income mother-infants at low risk for obesity. To inform the design of an RCT a higher-risk sample, we short-term, longitudinal study compare maternal feeding beliefs and behaviors, infant sleep, intake, growth African American formula (AAFF) dyads comparison sample White breastfeeding (WBF) dyads. We also assessed feasibility recruiting retaining AAFF participants. (n = 32) WBF 25)...