A5053091870- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Per- and polyfluoroalkyl substances research
- Air Quality Monitoring and Forecasting
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Energy and Environment Impacts
- Toxic Organic Pollutants Impact
- Vehicle emissions and performance
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Infant Nutrition and Health
- Noise Effects and Management
- Mitochondrial Function and Pathology
- Atmospheric chemistry and aerosols
- Diet and metabolism studies
- Atmospheric Ozone and Climate
- Cardiac Ischemia and Reperfusion
- Environmental Justice and Health Disparities
- Anesthesia and Neurotoxicity Research
- Fluorine in Organic Chemistry
- Global Health Care Issues
Emory University
2016-2025
Atlanta VA Medical Center
2024
Guangzhou Chemistry (China)
2024
Guangxi University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Guangxi University of Chinese Medicine
2024
Florida State University
2024
Chinese Center For Disease Control and Prevention
2022
New Orleans Public Library
2022
The novel human coronavirus disease 2019 (COVID-19) pandemic has claimed more than 600,000 lives worldwide, causing tremendous public health, social, and economic damages. Although the risk factors of COVID-19 are still under investigation, environmental factors, such as urban air pollution, may play an important role in increasing population susceptibility to pathogenesis.We conducted a cross-sectional nationwide study using zero-inflated negative binomial models estimate association...
Prenatal exposures to per- and polyfluoroalkyl substances (PFAS) have been linked reduced fetal growth. However, the detailed molecular mechanisms remain largely unknown. This study aims investigate biological pathways intermediate biomarkers underlying association between serum PFAS growth using high-resolution metabolomics in a cohort of pregnant African American women Atlanta area, Georgia.Serum perfluorohexane sulfonic acid (PFHxS), perfluorooctane (PFOS), perfluorooctanoic (PFOA),...
Abstract Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- polyfluoroalkyl substances (PFAS) has been reported reduce length gestation, but the underlying mechanisms are unknown. In present study, we characterized molecular signatures prenatal PFAS exposure gestational age at outcomes in newborn dried blood spot metabolome among 267 African American dyads Atlanta, Georgia between 2016 2020. Pregnant people with higher serum...
Per- and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the US population has been linked to adverse health outcomes including cardiometabolic diseases, immune dysregulation endocrine disruption. However, metabolic mechanism underlying effect of PFASs unknown.The aim this project investigate association between altered pathways increased risk in young adults.A total 102 adults with 82% overweight or obese participants were enrolled from Southern California 2014 2017....
Abstract Background The novel human coronavirus disease 2019 (COVID-19) pandemic has claimed more than 240,000 lives worldwide, causing tremendous public health, social, and economic damages. While the risk factors of COVID-19 are still under investigation, environmental factors, such as urban air pollution, may play an important role in increasing population susceptibility to pathogenesis. Methods We conducted a cross-sectional nationwide study using zero-inflated negative binomial models...
Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite abundance observational and controlled studies reporting associations between traffic sources exacerbation hospitalizations.To identify molecular pathways perturbed following exposures, we analyzed data as part Atlanta Commuters Exposure (ACE-2) study, a crossover panel commuters without asthma.We measured 27 pollutants conducted high-resolution metabolomics profiling...
Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air among women could enhance our understanding of potential biological pathways underlying pollution's reproductive toxicity. To identify serum metabolites associated and evaluate extent to which these mediate association between live birth. We included 200 undergoing a fresh assisted technology (ART) cycle at Massachusetts General Hospital Fertility Center...
Epidemiological evidence suggests air pollution adversely affects cognition and increases the risk of Alzheimer's disease (AD), but little is known about biological effects fine particulate matter (PM2.5, with aerodynamic diameter ≤2.5μm) on early predictors future risk.
Fine particulate matter (PM
Abstract Background A better understanding of lung cancer etiology and the development screening biomarkers have important implications for prevention. Methods We included 623 matched case–control pairs from Cancer Prevention Study (CPS) cohorts. Pre-diagnosis blood samples were collected between 1998 2001 in CPS-II Nutrition cohort 2006 2013 CPS-3 sent metabolomics profiling simultaneously. Cancer-free controls at time case diagnosis 1:1 to cases on date birth, draw date, sex,...
Abstract INTRODUCTION Growing evidence indicates that fine particulate matter (PM 2.5 ) is a risk factor for Alzheimer's disease (AD), but the underlying mechanisms have been insufficiently investigated. We hypothesized differential DNA methylation (DNAm) in brain tissue as potential mediator of this association. METHODS assessed genome‐wide DNAm (Illumina EPIC BeadChips) prefrontal cortex and three AD‐related neuropathological markers (Braak stage, CERAD, ABC score) 159 donors, estimated...
Epidemiological studies in adults have shown that exposure to ambient air pollution (AAP) is associated with the composition of adult gut microbiome, but these relationships not been examined infancy. We aimed determine if 6-month postnatal AAP was infant microbiota at 6 months age a cohort Latino mother-infant dyads from Southern California Mother's Milk Study (n = 103). estimated particulate matter (PM2.5 and PM10) nitrogen dioxide (NO2) birth 6-months based on residential address...
Background: Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, few large studies have focused on autism-related outcomes. We investigated whether blood concentrations of PFAS in pregnancy are associated child Methods: included 10 cohorts from the National Institutes Health (NIH)-funded Environmental influences Child Outcomes (ECHO) program (n = 1,429). measured 14 analytes maternal collected during...
Prenatal exposure to single chemicals belonging the per- and polyfluoroalkyl substances (PFAS) family is associated with biological perturbations in mother, fetus, placenta, plus adverse health outcomes. Despite our knowledge that humans are exposed multiple PFAS, potential joint effects of PFAS on metabolome remain largely unknown. Here, we leveraged high-resolution metabolomics identify metabolites metabolic pathways perturbed by a mixture during pregnancy. Targeted assessment...
Hypoxia administered after transient global cerebral ischemia (tGCI) has been shown to induce neuroprotection in adult rats, but the underlying mechanisms for this protection are unclear. Here, we tested hypothesis that hypoxic postconditioning (HPC) induces through upregulation of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth (VEGF), involves phosphatidylinositol-3-kinase (PI3K), p38 mitogen–activated protein kinase (p38 MAPK), mitogen-activated kinase/extracellular...
Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has unique role regulation autophagy. Hypoxic preconditioning (HPC) provides neuroprotection against transient global cerebral ischemia (tGCI). However, underlying mechanisms remain poorly understood. Thus, current study explored potential molecular mechanism neuroprotective effect HPC by investigating how Rab7 mediates autophagosome (AP) maturation after tGCI adult...
Background: The novel human coronavirus disease 2019 (COVID-19) pandemic has claimed more than 240,000 lives worldwide, causing tremendous public health, social, and economic damages. While the risk factors of COVID-19 are still under investigation, environmental factors, such as urban air pollution, may play an important role in increasing population susceptibility to pathogenesis. Methods: We conducted a cross-sectional nationwide study using zero-inflated negative binomial models estimate...