A5013128000- Air Quality and Health Impacts
- Birth, Development, and Health
- Climate Change and Health Impacts
- Gestational Diabetes Research and Management
- Per- and polyfluoroalkyl substances research
- Maternal Mental Health During Pregnancy and Postpartum
- Energy and Environment Impacts
- Noise Effects and Management
- Global Health Care Issues
- Smoking Behavior and Cessation
- Vitamin D Research Studies
- Breastfeeding Practices and Influences
- Effects and risks of endocrine disrupting chemicals
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Pregnancy and preeclampsia studies
- Health disparities and outcomes
- Anesthesia and Neurotoxicity Research
- Cardiovascular Health and Risk Factors
- Prenatal Screening and Diagnostics
- Sleep and related disorders
- Cancer Risks and Factors
- Fluoride Effects and Removal
University of Southern California
2020-2025
Okayama University
2025
Southern California University for Professional Studies
2022-2024
Keck Hospital of USC
2023-2024
BGI Group (China)
2023-2024
BGI Research
2024
University of Chinese Academy of Sciences
2023-2024
California State University, Northridge
2023
Per- and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the US population has been linked to adverse health outcomes including cardiometabolic diseases, immune dysregulation endocrine disruption. However, metabolic mechanism underlying effect of PFASs unknown.The aim this project investigate association between altered pathways increased risk in young adults.A total 102 adults with 82% overweight or obese participants were enrolled from Southern California 2014 2017....
Recent studies in Canadian and Mexican populations suggest an association of higher prenatal fluoride exposure with poorer neurobehavioral development, but whether this holds for US-based is unknown.
Importance Fetal growth is precisely programmed and could be interrupted by environmental exposures during specific times pregnancy. Insights on potential sensitive windows of air pollution exposure in association with birth weight are needed. Objective To examine the ambient heterogeneity individual- neighborhood-level stressors. Design, Setting, Participants Data a cohort low-income Hispanic women singleton term pregnancy were collected from 2015 to 2021 ongoing Maternal Developmental...
Air pollution has been associated with gestational diabetes mellitus (GDM). We aim to investigate susceptible windows of air exposure and factors determining population vulnerability. ascertained GDM status in the prospective Maternal Developmental Risks from Environmental Social Stressors (MADRES) pregnancy cohort Los Angeles, California, USA. calculated relative risk by ambient particulate matter (PM10; PM2.5), nitrogen dioxide (NO2), ozone (O3) each week 12 weeks before 24 after...
Personal exposure to fine particulate matter (PM
Abstract Context Worldwide, obesity remains one of the most challenging crises with children being susceptible populations. The effect maternal stress during pregnancy on newborn body composition, measured by fat mass and lean has, not been extensively studied. Objectives We evaluated association between perceived late infant adiposity at 1 month assessed modification sex preterm birth. Methods Mother-infant dyads (N = 138) were included from ongoing MADRES cohort. Maternal was 10-item...
BACKGROUND: Psychosocial stress is a cardiovascular risk factor; however, little known about whether prenatal psychosocial stressors influence postpartum health. We aimed to examine the associations of multiple measures on maternal blood pressure (BP) in first 4 years after birth. METHODS: Among 225 MADRES cohort (Maternal and Developmental Risks From Environmental Social Stressors) participants, we examined average Perceived Stress Scale (PSS), Center for Epidemiological Studies Depression...
Evidence suggests organophosphate esters (OPEs) are neurotoxic; however, the epidemiological literature remains scarce. We investigated whether prenatal exposures to OPEs were associated with child neurobehavior in MADRES cohort.We measured nine OPE metabolites 204 maternal urine samples (gestational age at collection: 31.4 ± 1.8 weeks). Neurobehavior problems assessed among 36-month-old children using Child Behavior Checklist's (CBCL) three composite scales [internalizing, externalizing,...
Diet during pregnancy may be a potential intervention for preventing hypertensive disorders of that disproportionally burdens Hispanic/Latina women.
Introduction Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals found in household products that can cross the placenta during pregnancy. We investigated whether PFAS exposure pregnancy was associated with infant birth outcomes a predominantly urban Hispanic population. Methods Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorohexanesulfonic (PFHxS), perfluorononanoic (PFNA), perfluorodecanoic (PFDA) were...
Perfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals with long half-lives and known to cross the placenta during pregnancy. We examined influence of maternal PFAS levels on
Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure potential vulnerability by comorbidities, such as prenatal depression, remain unclear.
It is well documented that persons of color experience disproportionate exposure to environmental contaminants, including air pollution, and have poorer pregnancy outcomes. This study assessed the critical windows ambient pollution on in utero fetal growth among structurally marginalized populations urban Los Angeles.Participants (N = 281) from larger ongoing MADRES cohort were included this analysis. Fetal outcomes measured average at 32 [Formula: see text] 2 weeks gestation by a certified...
We examined the associations between social support and postpartum mental health in 137 U.S. foreign-born Latinas MADRES pregnancy cohort. also whether language, years U.S., country of birth moderates these relationships. Participants were administered PROMIS measures 1 month postpartum; Perceived Stress Postpartum Distress Measure 3, 6, 12 months CESD scale postpartum. stress was lower at 6 for women reporting higher emotional (p = 0.01), informational 0.03), instrumental < 0.001); 0.01)....
Air pollution is a hazardous contaminant, exposure to which has substantial consequences for health during critical periods, such as pregnancy. MicroRNA (miRNA) an epigenetic mechanism that modulates transcriptome responses the environment and been found change in reaction air exposure. The data are limited regarding extracellular-vesicle (EV) miRNA variation associated with pregnancy susceptible populations who may be disproportionately exposed. This study aimed identify EV-miRNA expression...
Abstract Analyzing cell types of origin cell-free RNA can enhance the resolution liquid biopsies, thereby deepening understanding molecular and cellular changes in development disease processes. Existing deconvolution methods typically rely on meticulously curated gene expression profiles or employ deep neural network with vast complex solution spaces that are difficult to interpret. These approaches overlook synergistic co-expression effects among genes biological signaling pathways,...
Abstract Background Ambient air pollution has been linked to postpartum depression. However, few studies have investigated the effects of traffic-related NO x on depression and whether any pregnancy-related factors might increase susceptibility. Objectives To evaluate association between depressive anxiety symptoms, effect modification by hypertension. Methods This study included 453 predominantly low-income Hispanic/Latina women in MADRES cohort. Daily concentrations road class were...