A5063846847- Metabolomics and Mass Spectrometry Studies
- Per- and polyfluoroalkyl substances research
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality Monitoring and Forecasting
- Vitamin D Research Studies
- Diet and metabolism studies
- Advanced Chemical Sensor Technologies
- Climate Change and Health Impacts
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Carcinogens and Genotoxicity Assessment
- Parkinson's Disease Mechanisms and Treatments
- Childhood Cancer Survivors' Quality of Life
- Tryptophan and brain disorders
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Delphi Technique in Research
- Pesticide Exposure and Toxicity
Emory University
2015-2025
Icahn School of Medicine at Mount Sinai
2018-2024
Georgia Department of Public Health
2018-2024
Brigham and Women's Hospital
2022
Boston Children's Museum
2022
Boston Children's Hospital
2022
Emory and Henry College
2022
Harvard University
2022
University of Kansas
2021
Walker (United States)
1998-2019
Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. Here we show that HKL blocks agonist-induced pressure overload-mediated, cardiac hypertrophic responses, ameliorates pre-existing hypertrophy, in mice. Our data suggest anti-hypertrophic effects depend on activation deacetylase Sirt3. We demonstrate present mitochondria, enhances Sirt3 expression nearly twofold may bind to...
Improved analytical technologies and data extraction algorithms enable detection of >10 000 reproducible signals by liquid chromatography–high-resolution mass spectrometry, creating a bottleneck in chemical identification. In principle, measurement more than one million chemicals would be possible if were available to facilitate utilization the raw spectrometry data, especially low-abundance metabolites. Here we describe an automated computational framework annotate ions for identity using...
Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood urine. However, ISF has received limited attention due largely to lack simple collection methods. Here, we developed a minimally invasive, microneedle-based method sample from human skin was well tolerated by participants. Using microneedle patch create array micropores in coupled with mild suction, sampled 21 participants identified clinically...
The exposome is the cumulative measure of environmental influences and associated biological responses throughout lifespan, including exposures from environment, diet, behavior, endogenous processes. A major challenge for research lies in development robust affordable analytic procedures to broad range biologic impacts occurring over a lifetime. Biomonitoring an established approach evaluate internal body burden exposures, but use biomonitoring often limited by high costs with quantification...
Toxicant-associated steatohepatitis has been described in adults but less is known regarding the role of toxicants liver disease children. Perfluoroalkyl substances (PFAS) cause hepatic steatosis rodents, few previous studies have examined PFAS effects on severity injury We aimed to examine relationship histologic nonalcoholic fatty (NAFLD) Seventy-four children with physician-diagnosed NAFLD were recruited from Children's Healthcare Atlanta between 2007 and 2015. Biopsy-based histological...
Reference standardization was developed to address quantification and harmonization challenges for high-resolution metabolomics (HRM) data collected across different studies or analytical methods. relies on the concurrent analysis of calibrated pooled reference samples at predefined intervals enables a single-step batch correction high-throughput metabolomics. Here, we provide quantitative measures approximately 200 metabolites each three materials (220 Qstd3, 211 CHEAR, 204 NIST1950) show...
The first evidence of micro- and nanoplastic (MNP) exposure in the human placenta is emerging. However, toxicokinetics toxicity MNPs placenta, specifically environmentally relevant particles, remain unclear.We examined transport, uptake, pristine experimentally weathered nonsyncytialized syncytialized BeWo b30 choriocarcinoma cells.We performed untargeted chemical characterization using liquid chromatography high-resolution mass spectrometry to evaluate compositional differences following...
We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well biomarkers of TB onset, progression resolution. Such data may inform development anti-tuberculosis drugs. Plasma samples from adults with newly diagnosed pulmonary their matched, asymptomatic, sputum culture-negative household contacts were analyzed using liquid chromatography high-resolution mass spectrometry (LC-MS) metabolites. Statistical...
To examine the prospective associations between exposure to perfluoroalkyl substances (PFASs) and longitudinal measurements of glucose metabolism in high-risk overweight obese Hispanic children.Forty children (8-14 years) from urban Los Angeles underwent clinical measures 2-hour oral tolerance tests (OGTT) at baseline a follow-up visit (range: 1-3 years after enrollment). Baseline plasma perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic (PFHxS),...
Progression of Parkinson's disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection management. Unfortunately, this represents a complex problem due to the heterogeneous nature humans in regards demographic characteristics, genetics, diet, environmental exposures health behaviors. In pilot study, we employed high resolution mass spectrometry-based metabolic profiling investigate...
Per- and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the US population has been linked to adverse health outcomes including cardiometabolic diseases, immune dysregulation endocrine disruption. However, metabolic mechanism underlying effect of PFASs unknown.The aim this project investigate association between altered pathways increased risk in young adults.A total 102 adults with 82% overweight or obese participants were enrolled from Southern California 2014 2017....
Abstract Background Insulin impairment and inflammation are two features common to type 2 diabetes Alzheimer’s disease; however, the molecular signaling interactions underlying this relationship not well understood. Mounting evidence point associations between disruption of metabolite processing in insulin neurodegenerative conditions such as Alzheimer’s. Although brain depends partially on metabolites processed periphery, date, little is known about how soluble tumor necrosis factor...
Background: Occupational exposure to trichloroethylene (TCE) has been linked adverse health outcomes including non-Hodgkin's lymphoma and kidney liver cancer; however, TCE's mode of action for development these diseases in humans is not well understood. Methods: Non-targeted metabolomics analysis plasma obtained from 80 TCE-exposed workers [full shift range 0.4 230 parts-per-million air (ppma)] 95 matched controls were completed by ultra-high resolution mass spectrometry. Biological response...
Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite abundance observational and controlled studies reporting associations between traffic sources exacerbation hospitalizations.To identify molecular pathways perturbed following exposures, we analyzed data as part Atlanta Commuters Exposure (ACE-2) study, a crossover panel commuters without asthma.We measured 27 pollutants conducted high-resolution metabolomics profiling...
Interstitial fluid (ISF) surrounds the cells and tissues of body. Since ISF has molecular components similar to plasma, as well compounds produced locally in tissues, it may be a valuable source biomarkers for diagnostics monitoring. However, there not been comprehensive study determine metabolite composition compare plasma. In this study, metabolome suction blister (SBF), which largely consists ISF, collected from 10 human volunteers was analyzed using untargeted high-resolution...
The holistic characterisation of the human internal chemical exposome using high-resolution mass spectrometry (HRMS) would be a step forward to investigate environmental ætiology chronic diseases with an unprecedented precision. HRMS-based methods are currently operational reproducibly profile thousands endogenous metabolites as well externally-derived chemicals and their biotransformation products in large number biological samples from cohorts. These approaches provide solid ground for...