A5053614786- Air Quality and Health Impacts
- Birth, Development, and Health
- Energy and Environment Impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Climate Change and Health Impacts
- Pregnancy and preeclampsia studies
- Heavy Metal Exposure and Toxicity
- Pregnancy and Medication Impact
- Obesity, Physical Activity, Diet
- Noise Effects and Management
- Health disparities and outcomes
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Breastfeeding Practices and Influences
- Smoking Behavior and Cessation
- Respiratory Support and Mechanisms
- Urban Transport and Accessibility
- Congenital Heart Disease Studies
- Spine and Intervertebral Disc Pathology
- Per- and polyfluoroalkyl substances research
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Health, Environment, Cognitive Aging
University of Southern California
2016-2024
Southern California University for Professional Studies
2019-2023
Children's Hospital of Los Angeles
2015-2018
LAC+USC Medical Center
2018
Cornell University
2017
Deutsches Herzzentrum der Charité
2012-2015
The burden of childhood and adult obesity disproportionally affects Hispanic African-American populations in the US, these groups as well with lower income education levels are disproportionately affected by environmental pollution. Pregnancy is a critical developmental period where maternal exposures may have significant impacts on infant growth future health mother. We initiated "Maternal And Developmental Risks from Environmental Social Stressors (MADRES)" cohort study to address gaps...
Background: Reduced fetal growth increases the risk for adverse health outcomes. Growing evidence suggests that metal exposures contribute to reduced growth, but little is known about effects of complex mixtures. Objectives: We investigated impact a mixture metals on birth weight gestational age (BW GA) in Maternal and Developmental Risks from Environmental Social Stressors study, predominately lower-income Hispanic pregnancy cohort Los Angeles, California. Methods: Cadmium (Cd), cobalt...
Importance Fetal growth is precisely programmed and could be interrupted by environmental exposures during specific times pregnancy. Insights on potential sensitive windows of air pollution exposure in association with birth weight are needed. Objective To examine the ambient heterogeneity individual- neighborhood-level stressors. Design, Setting, Participants Data a cohort low-income Hispanic women singleton term pregnancy were collected from 2015 to 2021 ongoing Maternal Developmental...
Objective: To investigate the feasibility of ‘tele-rounding’ in neonatal intensive care. Methods: In this prospective study utilizing telemedicine technology NICU for daily patient bedside rounds (‘tele-rounds’), twenty pairs neonates were matched according to gestational age, diagnoses, and disease severity. One was cared by on-site team lead an neonatologist. The other but led off-site neonatologist using a remote-controlled robot. Patient rounding data, clinical outcomes, length stay,...
Personal exposure to fine particulate matter (PM
Disproportionately high rates of maternal overweight and obesity among the Hispanic population before, during, after pregnancy pose serious health concerns for both mothers (e.g., preeclampsia, gestational diabetes, weight retention) children elevated lifelong risk). A growing body evidence implicates environmental exposures air pollution, metals) social stressors poverty, violence) in contributing to obesity-related biobehavioral processes, such as physical activity, dietary intake,...
Abstract Background Depression is the leading cause of mental health-related morbidity and affects twice as many women men. Hispanic/Latina in US have unique risk factors for depression they lower utilization health care services. Identifying modifiable maternal depression, such ambient air pollution, an urgent public priority. We aimed to determine whether prenatal exposure pollutants was associated with at 12 months after childbirth. Methods One hundred eighty predominantly low-income...
Prenatal air pollution exposure may increase risk for childhood obesity. However, few studies have evaluated in utero growth measures and infant weight trajectories. This study will evaluate the associations of prenatal to ambient pollutants with trajectories from 3rd trimester through age 2 years.
Diet during pregnancy may be a potential intervention for preventing hypertensive disorders of that disproportionally burdens Hispanic/Latina women.
Circulating miRNA may contribute to the development of adverse birth outcomes. However, few studies have investigated extracellular vesicle (EV) miRNA, which play important roles in intercellular communication, or compared at multiple time points pregnancy. In current study, 800 were profiled for EVs from maternal plasma collected early (median: 12.5 weeks) and late 31.8 pregnancy 156 participants MADRES Study, a health disparity cohort. Associations between weight, weight gestational age...
Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute maternal-foetal communication and are dysregulated in However, metal impacts on maternal circulating EV during unknown. Our objective was investigate the impact of multiple exposures circulation MADRES Study. Associations between urinary concentrations nine 106 plasma were investigated using robust linear regression (N = 231). Primary analyses focused metal-miRNA associations early...
MicroRNA (miRNA) circulating in plasma have been proposed as biomarkers for a variety of conditions and diseases, including complications during pregnancy. During pregnancy, about 15–25% maternal exosomes, small size-class EVs, are hypothesized to originate the placenta, may play role communication between fetus mother. However, few studies addressed changes miRNA over course pregnancy with repeated measures, nor focused on diverse populations. We describe early late from MADRES cohort...
Abstract A growing number of studies have associated walkability and greenspace exposure with greater physical activity (PA) in women during pregnancy. However, most focused on examining women’s residential environments neglected locations outside the home neighborhood. Using 350 person-days ( N = 55 participants) smartphone global positioning system (GPS) location accelerometer data collected first third trimesters 4–6 months postpartum from Hispanic pregnant Maternal Developmental Risks...
Patients with congenital heart disease (CHD) demonstrate multidomain cognitive delays. Cingulo-opercular and cerebellar brain networks are critical to language functions. This is a description of our initial experience aiming identify an anatomic correlate for CHD patients expressive Fetal patients, prospectively enrolled, underwent serial fetal (1.5T), postnatal pre- postoperative (3T) MRI. Non-CHD were enrolled retrospectively from the same epoch. Comparable neonatal T2 contrast was used...
Determination of cardiac output requires measurement both heart rate and stroke volume. Techniques for measuring are widespread, 1 technique bedside monitoring volume is electrical impedance cardiography.To determine the accuracy precision measured via cardiography whether can be used to detect trends.Eleven healthy research participants (22-52 years old) were examined with simultaneous phase-contrast magnetic resonance imaging at rest during exercise. Bland-Altman analysis repeated-measures...
Infant birth weight influences numerous health outcomes throughout the life course including childhood obesity and metabolic morbidities. Maternal experience of stress, both before during pregnancy, has been hypothesized to influence fetal growth outcomes. However, these associations currently are not fully understood, due conflicting results in published literature. Salivary cortisol is often used as a biological biomarker assess diurnal pattern hypothalamic-pituitary-adrenal axis...