A5101570739- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA regulation and disease
- Plant tissue culture and regeneration
- Mitochondrial Function and Pathology
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
- melanin and skin pigmentation
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Hair Growth and Disorders
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Tryptophan and brain disorders
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Phylogenetic Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plant-Microbe Interactions and Immunity
- Extracellular vesicles in disease
- Clostridium difficile and Clostridium perfringens research
Chinese Academy of Tropical Agricultural Sciences
2015-2025
Ministry of Agriculture and Rural Affairs
2025
Institute of Crop Sciences
2020-2024
Chinese Academy of Agricultural Sciences
2020-2024
Zhejiang Hospital
2024
Guangxi Veterinary Research Institute
2024
South Subtropical Crops Research Institute
2020-2023
Gansu Agricultural University
2023
University of Minnesota
2023
Shandong University of Technology
2022
Summary Drought and salt stresses impose major constraints on soybean production worldwide. However, improving agronomically valuable traits under drought conditions can be challenging due to trait complexity multiple factors that influence yield. Here, we identified a nuclear factor Y C subunit (NF‐YC) family transcription member, GmNF‐YC14, which formed heterotrimer with GmNF‐YA16 GmNF‐YB2 activate the GmPYR1‐mediated abscisic acid (ABA) signalling pathway regulate stress tolerance in...
The prokaryotic CRISPR/Cas9 system has recently emerged as a powerful tool for genome editing in mammalian cells with the potential to bring curative therapies patients genetic diseases. However, efficient vivo delivery of this machinery and indeed very feasibility using these techniques remain challenging most tissue types. Here, we show that nonreplicable Cas9/sgRNA ribonucleoproteins can be used correct defects skin stem postnatal recessive dystrophic epidermolysis bullosa (RDEB) mice. We...
Summary Sterols have long been associated with diverse fields, such as cancer treatment, drug development, and plant growth; however, their underlying mechanisms functions remain enigmatic. Here, we unveil a critical role played by GmNF‐YC9‐mediated CCAAT‐box transcription complex in modulating the steroid metabolism pathway within soybeans. Specifically, this directly activates squalene monooxygenase (GmSQE1), which is rate‐limiting enzyme synthesis. Our findings demonstrate that...
With the aim of enhancing plants' ability to respond pathogenic fungi, this study focuses on disease resistance genes. We commenced a series investigations by capitalizing pronounced differences in Fusarium wilt between resistant and susceptible varieties. Through an in-depth exploration metabolic pathways that bolster defense, we identified genes associated with oxysporum f. sp. cubense (Foc). For our analysis, root tissues from seedlings had been contact for four days were harvested,...
Aquaporins (AQPs) function to selectively control the flow of water and other small molecules through biological membranes, playing crucial roles in various processes. However, little information is available on AQP gene family bananas. In this study, we identified 47 banana genes based genome sequence. Evolutionary analysis AQPs from banana, Arabidopsis, poplar, rice indicated that (MaAQPs) were clustered into four subfamilies. Conserved motif showed all contained typical AQP-like or major...
Nasopharyngeal carcinoma (NPC) is among the most common squamous cell in South China and Southeast Asia. Radiotherapy primary treatment for NPC. However, radioresistance acts as a significant factor that limits efficacy of radiotherapy NPC patients. Growing evidence supports microRNAs (miRNAs) play an important role radiation response. Real-time quantitative PCR was used to analyze expression miR-19b-3p lines NP69. profiles tissues were obtained from Gene Expression Omnibus database. The...
Ankyrin repeat (ANK) proteins are essential in cell growth, development and response to hormones environmental stresses. In the present study, 226 ANK genes were identified classified into nine subfamilies according conserved domains soybean genome (Glycine max L.). Among them, GmANK114 was highly induced by drought, salt, abscisic acid (ABA). The encodes a protein that belongs ANK-RF subfamily containing RING finger (RF) domain addition ankyrin repeats. Heterologous overexpression of...
Hypoxia administered after transient global cerebral ischemia (tGCI) has been shown to induce neuroprotection in adult rats, but the underlying mechanisms for this protection are unclear. Here, we tested hypothesis that hypoxic postconditioning (HPC) induces through upregulation of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth (VEGF), involves phosphatidylinositol-3-kinase (PI3K), p38 mitogen–activated protein kinase (p38 MAPK), mitogen-activated kinase/extracellular...
ABSTRACT Hypoxic preconditioning (HPC) alleviates the selective and delayed neuronal death in hippocampal CA1 region induced by transient global cerebral ischemia (tGCI). This type of cell may include different programmed mechanisms, namely, apoptosis necroptosis. Although apoptotic signaling is well defined, mechanisms that underlie necroptosis are yet to be fully elucidated. In this study, we investigated whether HPC protects neurons from ischemia‐induced We observed tGCI up‐regulated...
Metabolites are major biological parameters sensed by many cell types in vivo, whether they function as signaling mediators of SC and niche cross talk to regulate tissue regeneration is largely unknown. We show here that deletion the Notch pathway co-factor RBP-J specifically mouse HFSCs triggers adjacent McSCs precociously differentiate their shared niche. Transcriptome screen vivo functional studies revealed elevated level retinoic acid (RA) caused de-repression RA metabolic process genes...
Possible sarcopenia (PS) and depression are prevalent among middle-aged older adults. However, few studies have evaluated the causal association between PS, as well its components. This study conducted both cross-sectional longitudinal analyses to explore relationship PS in a population aged 45 oledr. We components with using data from China Health Retirement Longitudinal Study (CHARLS). was assessed according Asian Working Group for gudielines established 2019 (AWGS 2019). Depression...
<title>Abstract</title> Objective The increasing threat of infectious diseases necessitates robust genomic resources for rapid and accurate analysis human pathogens. Human Pathogen Database (HPD) addresses this need by providing a comprehensive, curated collection pathogen data. database was built on high-quality, manually organized data pathogens, offering an interactive interface online browsing, searching, downloading, sequence alignment Results current iteration HPD encompassed...
Introduction Unbiased metagenomic sequencing (mNGS) is crucial for infectious disease diagnosis and epidemiological surveillance. However, its analysis requires specialized bioinformatics skills, creating barriers clinicians. We developed HPD-Kit (Henbio Pathogen Detection Toolkit) with an integrated pathogen database to simplify detection both human animal pathogens. Methods includes a specifically curated optimized pipeline. evaluated performance using simulated datasets at varying...
A recent study found that dysregulated microRNA-184 (miR-184) is involved in the proliferation and survival of nasopharyngeal carcinoma (NPC). This aimed to evaluate detailed mechanisms invasion, migration metastasis NPC cells.Quantitative reverse-transcription PCR (qRT-PCR) Western blot were used confirm expression levels miR-184 Notch2. cell invasion subsequently examined using vitro wound-healing assays, respectively. MicroRNA (miRNA) target gene prediction databases dual-luciferase...
Background and aims: Trimethylamine N-oxide (TMAO), a pro-atherosclerotic intestinal microbiota metabolite, has mechanistic links to atherosclerosis development cardiovascular diseases. In this study, we aimed investigate whether serum TMAO levels could predict early neurological deterioration (END) after acute ischemic stroke.Methods: We prospectively recruited patients with first-ever stroke hospitalized within 24 h of symptoms onset during Mar 2018 2019. Plasma were quantified using...
Excessive production of reactive oxygen species (ROS) leads to potential toxicity in an organism. Class III peroxidases (PRXs) play important role maintaining ROS homeostasis plants. Internal browning (IB) limits industrial development pineapple, which is the third most fruit trade world. IB mainly caused by ROS, and mechanism underlying still unknown from perspective ROS. Here, we soaked pineapples ascorbic acid after harvest before storage decrease excessive polyphenol oxidase (PPO)...
The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator autoimmunity. Here, we aim to characterize gut microbiota large cohort treatment-naïve anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis patients relative that healthy controls (HCs). Relative HCs, anti-NMDAR had decreased microbiome alpha-diversity index, marked disturbances microbial composition and intestinal permeability damage. Disturbed in might be linked with different...
microRNAs (miRNAs) play a crucial role in mediation of the cellular sensitivity to ionizing radiation (IR). Previous studies revealed that miR-300 was involved response IR or chemotherapy drug. However, whether could regulate DNA damage responses induced by extrinsic genotoxic stress human lung cancer and underlying mechanism remain unknown. In this study, expression examined cells treated with IR, effects on repair, cell cycle arrest, apoptosis senescence were investigated. It found...
Background: In recent years, miR-152 has been dysregulated in a variety of tumors and used as tumor suppressor. Nevertheless, its role nasopharyngeal carcinoma (NPC) remains unidentified. Materials methods: Real-time quantitative PCR (polymerase chain reaction) was performed to analyze the expression NPC cell lines. MiR-152 profiles tissues were obtained from Gene Expression Omnibus (GEO GSE36682). The effect on invasion proliferation cells determined through invasion, wound healing,...