A5101489637- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Hemodynamic Monitoring and Therapy
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Structural Anomalies and Repair
- Complex Network Analysis Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Opinion Dynamics and Social Influence
Harbin Medical University
2011-2024
Second Affiliated Hospital of Harbin Medical University
2012-2024
Harbin Engineering University
2014-2023
Nanjing Forestry University
2023
State Key Laboratory of Oncology in South China
2023
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Key Laboratory of Guangdong Province
2023
First Affiliated Hospital of Henan University
2018-2021
Jiangsu Cancer Hospital
2013-2020
Purpose: Triple-negative breast cancer (TNBC) is an especially aggressive and hard-to-treat disease. Although the anticancer role of kaempferol has been reported in cancer, effect on TNBC remains unclear. Materials methods: This experiment investigated migration-suppressive a low dose cells. Wound-healing assays cell invasion were used to confirm migration cells treated with or transfected indicated constructs. We evaluated activations RhoA, Rac1 Cdc42 Rho activation assay. A panel...
miR-203a-3p was reported as a tumor suppressor and disregulated in many malignancies including nasopharyngeal carcinoma (NPC). However, its function growth metastasis NPC has rarely been reported. The expression level of human tissues cell lines detected via real-time PCR (RT-PCR). Cell proliferation, migration invasion were assessed vitro by MTT, colony formation transwell assay, respectively. vivo through xenograft lung metastatic mice model. Dual-luciferase reporter assay used to identify...
A small-world simulation model of a regional innovation system combining the strength intersubject relationship with loosely coupled is constructed. We use to observe knowledge flow within under relationships varying strength. The results show that when between subjects reaches certain strength, will exhibit high module independence and network integrity, forming system. in exhibits emergence fast rate, mean value little variance. When at other levels, cannot be identified.
Abstract Background To evaluate the efficacy and outcomes of hypofractionated stereotactic radiotherapy (HSRT) for brain metastases > 3 cm. Methods From March 2003 to October 2009, 40 patients with larger than cm were treated by HSRT. HSRT was applied in 29 primary treatment 11 rescue. Single metastasis detected 21 patients. Whole incorporated into 10 treatment. boosts 23 The diameters ranged from 3.1 5.5 (median, 4.1 cm). median prescribed dose (not including boosts) Gy (range, 20-53 Gy)...
Lung cancer is notorious for high morbidity and mortality around the world. Interleukin (IL)-8, a proinflammatory chemokine with tumorigenic proangiogenic effects, promotes lung cells growth migration contributes to cell aggressive phenotypes. Integrin αvβ6 receptor of transmembrane heterodimeric surface adhesion, its overexpression correlates poor survival from non–small cancer. However, cross talk between IL-8 in has not been characterized so far. Herein, human samples were analyzed, it...
A recent study found that dysregulated microRNA-184 (miR-184) is involved in the proliferation and survival of nasopharyngeal carcinoma (NPC). This aimed to evaluate detailed mechanisms invasion, migration metastasis NPC cells.Quantitative reverse-transcription PCR (qRT-PCR) Western blot were used confirm expression levels miR-184 Notch2. cell invasion subsequently examined using vitro wound-healing assays, respectively. MicroRNA (miRNA) target gene prediction databases dual-luciferase...
Aim: This article aimed to determine treatment compliance, acute toxicities and the short-term curative effects of combining cetuximab with chemoradiation following induction chemotherapy locoregionally advanced nasopharyngeal carcinoma (NPC). Materials & methods: A total 21 patients NPC were scheduled receive one cycle followed by intensity-modulated radiotherapy, weekly administration concurrent (at least two cycles a limit six). Results: All completed planned 14 (67%) without breaks, 20...
This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with tumor volume and prognosis in patients locally advanced nasopharyngeal carcinoma (NPC). A total 165 newly diagnosed NPC were identified from September 2011 July 2012. EBV-DNA was detected using fluorescence quantitative polymerase chain reaction (PCR) amplification. The calculated by systematic summation method computer software. median copy number before treatment 3790 copies/mL....
Objective: To evaluate the characteristics and risk factors for locoregional recurrence in patients with nasopharyngeal carcinoma (NPC) treated intensity-modulated radiotherapy (IMRT). Methods: The clinical diagnosis treatment data of 195 NPC IMRT from March 2005 to May 2010 (including 9, 24, 70, 92 cases stage I, II, III, IV disease, respectively, according 7th edition American Joint Committee on Cancer staging criteria) were retrospectively analyzed. Kaplan-Meier method was used survival...
Abstract Background The purpose of this study was to review the survival and toxicity in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated intensity‐modulated radiation therapy (IMRT) concurrent nedaplatin plus paclitaxel or fluorouracil (NP NF). Methods A total 155 NPC seen at our institution between January 2008 December 2010 were retrospectively reviewed. Seventy‐nine cases (51%) IMRT NP chemotherapy, 76 (49%) NF regimen. Survival reported. Results 3‐year...
Abstract MicroRNA‐32 (miR‐32) functioned as a tumor oncogene in some cancer, which control genes involved important biological and pathological functions facilitate the growth metastasis. However, role of miR‐32 modulates esophageal squamous cell carcinoma (ESCC) malignant transformation has not been clarified. Here, we focused on function underlying molecular mechanism ESCC. Results discovered significant increased expression ESCC tissues cells. Downregulation inhibited migration, invasion,...
Aberrant microRNAs (miRNAs) expressions could contribute to the progression of numerous cancers, including esophageal squamous cell carcinoma, while miR-10a participates in multiple biological processes on cancers. However, molecular mechanism carcinoma (ESCC) has not been investigated. Herein, was significantly reduced ESCC clinical tissues and lines (EC109 TE-3). In addition, immunohistochemistry indicated that α-SMA, Ki-67, PCNA tumor were higher than controls. vitro, overexpression...
Abstract Background To evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) in patients with residual nasopharyngeal carcinoma (NPC). Methods From January 2000 to December 2009, 136 NPC lesions after primary (RT) were treated by FSRT. The total dose RT was 68.0-78.0 Gy (median, 70.0 Gy). median time from FSRT 24.5 days. Tumor volumes for ranged 0.60 77.13 cm3 13.45 cm3). doses 8.0-32.0Gy 19.5 Gy) 2.0-10.0 per fraction. Results Five-year local failure-free...
The objective of this study is to evaluate the contribution induction (IC) or adjuvant (AC) chemotherapy additional concurrent chemoradiotherapy (CCRT) for patients with T3-4N0-1 nasopharyngeal carcinoma (NPC) in era intensity-modulate radiotherapy (IMRT).We retrospectively reviewed data on 685 newly diagnosed NPC. Propensity score matching (PSM) method was used match patients. Survival outcomes between different groups were calculated by Kaplan-Meier and compared using log-rank test. Cox...
To explore the risk factors of distant brain failure (DBF) for patients with metastasis (BM) who were treated stereotactic radiotherapy alone and to group on basis their levels.We retrospectively analyzed 132 newly diagnosed BM from May 2000 April 2010. Kaplan-Meier Cox proportional hazards regression analyses performed univariate multivariate analyses.The 1-year incidence rate DBF was 44.7%, median time (MDBFT) 18 months. In analysis, number BMs greater than 1 (p = 0.041), uncontrolled...
Background: This study aimed to compare concurrent chemoradiotherapy (CCRT) plus cetuximab (C) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma(NPC). Methods: A total of 682 NPC patients who had undergone or without were included. Propensity score-matching method was used match patients. Progression-free survival (PFS), overall (OS), locoregional relapse-free (LRFS), and distant metastasis-free (DMFS) compared between the two treatment arms. Results: After matching, 225...
This study aims to evaluate the radiosensitization effect of nedaplatin on nasopharyngeal carcinoma (NPC) cell lines with different Epstein-Barr virus (EBV) status. Human NPC CNE-2 (EBV-negative) and C666 (EBV-positive) were treated 0-100 μg/mL nedaplatin, inhibitory effects viability IC50 calculated by MTS assay. We assessed changes in radiosensitivity cells colony formation assays, detected apoptosis index cycle flow cytometry. assay showed that caused significant cytotoxicity a time-...