A5109035006- Hormonal and reproductive studies
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Polymer crystallization and properties
- Urinary Bladder and Prostate Research
- Pain Mechanisms and Treatments
- HIV-related health complications and treatments
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- RNA Research and Splicing
- Alcohol Consumption and Health Effects
- Peptidase Inhibition and Analysis
- Hypothalamic control of reproductive hormones
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Sexual function and dysfunction studies
- Hepatitis C virus research
- Graph theory and applications
- Cancer Mechanisms and Therapy
- Genetic and phenotypic traits in livestock
- Microplastics and Plastic Pollution
- MicroRNA in disease regulation
First Affiliated Hospital Zhejiang University
2025
Guangxi Medical University
2014-2024
City University of Macau
2024
East China University of Science and Technology
2016-2024
National Yang Ming Chiao Tung University
2024
Nanjing Polytechnic Institute
2024
Guangxi Veterinary Research Institute
2024
Xinjiang Medical University
2024
Sun Yat-sen University Cancer Center
2023
Sun Yat-sen University
2022-2023
Breast cancer, which is the second leading cause of cancer-associated mortality in women worldwide, develops from breast tissue. Chemotherapy most commonly used therapy to treat cancer. However, a number natural plant-derived products have been suggested as alternative therapies different types such The aim present study was determine anti-tumor effects ursolic acid and its effect on apoptosis inflammation cancer cells. anti-cancer were evaluated vitro using flow cytometry, western blotting...
Triglyceride (TG) is a complex phenotype influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels; however, such in Chinese populations are limited. A two-stage GWAS were conducted to identify variants that associated with TG population of 3495 men. Gene–environment interactions on serum levels further investigated for the seven single nucleotide polymorphisms (SNPs) studied stages. Two previously...
Vitamin B12 (VitB12 or cobalamin) is an essential cofactor in several metabolic pathways. Clinically, VitB12 deficiency associated with pernicious anemia, neurodegenerative disorder, cardiovascular disease and gastrointestinal disease. Although previous genome-wide association studies (GWAS) identified genes, including FUT2, CUBN, TCN1 MUT, that may influence levels European populations, common genetic determinants of remain largely unknown, especially Asian populations. Here we performed a...
Fragile X mental retardation protein (FMRP) has been proposed to play a potential role in the pathogenesis of autonomy and nociceptive paresthesia. However, involvement spinal FMRP neuropathic pain remains unexplored. Using rat model induced by chronic constriction injury (CCI), our investigation demonstrated an upregulation at 3, 7, 14 days post-CCI operation dorsal horn (SDH). Immunofluorescence staining revealed predominant expression neurons, which colocalized with Glutamate Ionotropic...
Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) men presenting with metabolic syndrome (MetS) and/or insulin resistance. We aimed to determine independent relationship between SUA and NAFLD non-diabetic Chinese male population, explore determinants among indexes adiposity, lipid, genotypes pertaining triglycerides metabolism, inflammation, oxidative stress, concentrations. A total 1440 men, classified depending on...
•Patients with dmNPC receiving chemotherapy plus anti-PD-1 mAbs had an ORR of 92.0% and a median PFS 20 months.•Chemotherapy monoclonal antibodies followed by LRRT improves survival outcomes.•Early clearance EBV DNA is biomarker for identifying suitable candidates in the era immunotherapy. BackgroundWe aimed to investigate efficacy locoregional radiotherapy (LRRT) patients de novo metastatic nasopharyngeal carcinoma (dmNPC) combined anti-programmed cell death receptor-1 (anti-PD-1 mAbs) as...
The goal of present study was to examine the influence demographic characteristics, lifestyle, and metabolic factors on pressure-induced pain threshold.The population comprised 2,517 healthy men at second-phase recruitment a population-based cohort in China. pressure threshold (PPT) two locations, triceps inguinal lines, obtained using digital algometer. Education occupation, as well lifestyle factors, were self-reported face-to-face interview. Blood lipid fasting glucose measured routine...
Recent studies suggest that serum homocysteine (HCY) level is correlated to inflammatory/immune factors influence the development and progression of many diseases, such as cardiovascular disease. However, association between HCY in healthy populations has not been systematically investigated. This study was conducted based on Fangchenggang Area Male Health Examination Survey (FAMHES) project. After comprehensive baseline analysis, we could find any significant factors. next linear regression...
The amyloid precursor protein (APP) is well studied for its role in Alzheimer disease. However, little known about normal function. In this study, we examined the of APP neural stem/progenitor cell (NSPC) proliferation. NSPCs derived from APP-overexpressing Tg2576 transgenic mice proliferated more rapidly than corresponding background strain (C57Bl/6xSJL) wild-type mice. contrast, knock-out (APP-KO) had reduced proliferation rates when compared with (C57Bl/6). A secreted factor, identified...
Abstract Background Oxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD), prompting exploration antioxidants as a potential therapeutic avenue for mitigating progression. This study aims to investigate beneficial impact Tempol on progression CKD rat model utilizing oxidized albumin biomarker. Methods After four weeks treatment, metabolic parameters, including body weight, left ventricle residual urine volume, and water food intake, were measured. Systolic...
Influences of branch content (BC) and length (BL) on isothermal crystallization precisely branched polyethylene are studied by molecular dynamics simulation. Branch acts as a defect both in nucleation crystal growth process. BC affects not only kinetics but also final morphologies. Crystallization rate crystallinity decrease increases. Morphology Regimes change from lamellae to bundle at critical (20/1000 C) because different folding pattern. 50 CH 2 is the methyl sequence form crystal....
The two endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), play independent nonredundant roles in the body. This makes development of both selective dual inhibitors their inactivation an important priority. In this work we report a new series monoacylglycerol lipase (MAGL) fatty acid amide hydrolase (FAAH). Among them, (±)-oxiran-2-ylmethyl 6-(1,1'-biphenyl-4-yl)hexanoate (8) (2R)-(-)-oxiran-2-ylmethyl(4-benzylphenyl)acetate (30) stand out as potent human recombinant MAGL...
Summary Objective To examine the association of endogenous sex hormones and hormone‐binding globulin (SHBG) with C‐reactive protein ( CRP ) in Chinese men. Design participants The study population comprised 1989 men at baseline recruitment a population‐based cohort China. Participant information on risk factors was collected by face‐to‐face interview clinical examination. All subjects were without taking any kind medication for anti‐inflammation purpose or treatment hypogonadism value less...
Abstract Background Metabolic syndrome is often beneficial from testosterone replacement therapy. Although and sex hormone‐binding globulin (SHBG) are inversely associated with the risk of metabolic syndrome, it controversial whether association between independent SHBG. Methods Testosterone, SHBG were evaluated in 2361 men aged 20–73 years, who participated population‐based Fangchenggang Area Male Health Examination Survey. Total testosterone, other biochemical profiles measured. Free...
Multidrug resistance (MDR) in epithelial ovarian cancer (EOC) remains a public health issue for women worldwide, and its molecular mechanisms remain to be fully elucidated. The present study aimed predict the potential genes involved MDR, examine underlying MDR EOC using bioinformatics techniques. In study, four microarray datasets, including GSE41499, GSE33482, GSE15372 GSE28739, available Gene Expression Omnibus were downloaded, 11 microRNAs (miRNA; miRs), miR‑130a, miR‑214, let‑7i,...
Immune checkpoint blockade has attracted a lot of attention in the treatment human malignant tumors. We are trying to establish prognostic model gastric cancer (GC) based on expression profile immunoregulatory factor-related genes. Based TCGA database, we identified 234 differentially expressed factors. Gene Ontology (GO) and Kyoto Encyclopedia Genes Genomes (KEGG) conducted enrichment analysis clarify biological functions differential STRING database predicted interaction network between...
The presence of nonalcoholic fatty liver disease (NAFLD) is a strong risk predictor for type 2 diabetes (T2D). A reduction in sex hormone-binding globulin (SHBG) associated with NAFLD. Low SHBG also insulin resistance (IR). However, very limited data are available the association and IR patients study aims to clarify between In this cross-sectional study, 334 men NAFLD were recruited. SHBG, total testosterone, free cholesterol, triglyceride, insulin, glucose concentrations measured....