A5103235002- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Eicosanoids and Hypertension Pharmacology
- Paraquat toxicity studies and treatments
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Gastric Cancer Management and Outcomes
- Reproductive System and Pregnancy
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Food Quality and Safety Studies
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- RNA regulation and disease
- Heme Oxygenase-1 and Carbon Monoxide
- Endometriosis Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Postharvest Quality and Shelf Life Management
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
Minhang District Central Hospital
2021-2025
Fudan University
2021-2025
Inner Mongolia University of Science and Technology
2022-2025
Chinese Academy of Agricultural Sciences
2013-2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2015-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Guangxi University of Chinese Medicine
2023
Chinese People's Armed Police Force
2017-2019
Logistics University of People's Armed Police Force
2017-2019
Ministry of Agriculture
2018-2019
Paraquat (PQ) is an effective and commercially important herbicide that widely used worldwide. However, PQ highly toxic can cause various complications acute organ damage. Aspirin eugenol ester (AEE) a potential new compound with anti-inflammatory antioxidant stress pharmacological activity. The present study was to reveal the therapeutic effects protective effect of AEE against PQ-induced lung injury (ALI) help oxidative damage in A549 cells rats. might have no significant on had...
Background and Purpose Aspirin eugenol ester (AEE) is a new drug compound synthesized by combining aspirin with eugenol. It was reported to possess anti‐thrombotic, anti‐atherosclerotic, anti‐oxidative effects. However, its molecular mechanism against oxidative injury unclear. This study investigated how AEE affected the of vascular endothelial cells in vivo vitro. Experimental Approach A hamster model atherosclerosis induced high fat diet (HFD) an vitro stress, H 2 O ‐induced apoptosis...
Salinity stress is a major abiotic factor that adversely affects plant growth and development. This study investigated the physiological molecular responses of Brassica rapa L. ssp. Pekinensis to salinity by subjecting seedlings varying concentrations NaCl. Physiological analysis revealed significant wilting, chlorosis, marked reduction in chlorophyll carotenoid contents NaCl-treated seedlings, indicating impaired photosynthetic efficiency oxidative mitigation. RNA-seq identified extensive...
Thioflavin T (ThT) is widely used as a fluorescent probe for amyloid fibril detection. Yet the exact kinetic mechanism of ThT binding onto remains elusive. Previously reported studies using ThT-fluorescence-detected design suggested two completely different ThT-binding mechanisms. In one study, multistep sequential single site was suggested. another one-step parallel multiple sites The discrepancy likely due to incapability differentiate above-mentioned Considering weakness approach, we...
Hyperlipidemia is an important lipid disorder and a risk factor for health. Aspirin eugenol ester (AEE) novel synthetic compound which made up of two chemical structural units from aspirin eugenol. Therapeutic effect AEE on hyperlipidemia has been confirmed in animal model. But the action mechanism still poorly understood. In this study, we investigated effects liver feces metabolic profile through UPLC-Q-TOF/MS-based untargeted metabolomics hamster induced with high fat diet (HFD),...
Naringenin, a flavanone, has been reported for wide range of pharmacological activities. However, there are few reports on the absorption, transport and antioxidant effects naringenin. The study was to explore uptake, naringenin in vitro. Cell transmembrane resistance, lucifer yellow transmission rate, alkaline phosphatase activity were used evaluate successful construction cell model. results showed that absorption by Caco-2 cells time- concentration-dependent. Different temperatures (37...
Atherosclerosis is a chronic immune inflammatory disease. Aspirin eugenol ester (AEE) novel safe and non-toxic compound with many pharmacological effects such as anti-inflammatory, anti-hyperlipidemic anti-thrombotic action. In order to investigate the effect of AEE on inhibition aortic lipid plaque formation macrophage-derived foam cell induced by oxidized low density lipoprotein (ox-LDL), in vivo atherosclerosis model feeding ApoE-/- mice high-fat diet cells vitro ox-LDL-induced RAW264.7...
Chemotherapy is a classical method of cancer treatment. Cisplatin-based chemotherapy traditional and essential therapeutic approach in gastric However, the development drug resistance during treatment major obstacle that limits their further application, molecular changes have occurred resistance. Here, we found Dickkopf-related protein 1 (DKK1) highly expressed related to poor prognosis patients through public database mining. Next, also identified DKK1 CDDP-resistant cell lines, supporting...
Hyperlipidemia, with an increasing of prevalence, has become one the common metabolic diseases in companion animal clinic. Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hyperlipidemia activities. However, its mechanisms are still not completely known. The objective present study was to investigate intervention effects AEE on cecal contents metabonomics profile and microbiota hyperlipidemia rats.Three groups rats were fed control diet, or high fat diet (HFD)...
Immune checkpoint blockade has attracted a lot of attention in the treatment human malignant tumors. We are trying to establish prognostic model gastric cancer (GC) based on expression profile immunoregulatory factor-related genes. Based TCGA database, we identified 234 differentially expressed factors. Gene Ontology (GO) and Kyoto Encyclopedia Genes Genomes (KEGG) conducted enrichment analysis clarify biological functions differential STRING database predicted interaction network between...
BACKGROUND The treatment of gastric cancer (GC) has caused an enormous social burden worldwide. Accumulating studies have reported that N6-methyladenosine (m6A) is closely related to tumor progression. METTL5 a m6A methyltransferase plays pivotal role in maintaining the metabolic stability cells. However, its aberrant regulation GC not been fully elucidated. AIM To excavate development GC. METHODS expression and clinicopathological characteristics were analyzed via Cancer Genome Atlas...
Abstract Based on the pro-drug principle, aspirin and eugenol were used to synthesize ester (AEE) by esterification reaction. In present study, anti-atherosclerosis effects of AEE investigated in hamsters with utilization metabonomic approach based UPLC-Q-TOF/MS. Biochemical parameters histopathological injures stomach, liver aorta evaluated. atherosclerotic hamster, oral administration normalized biochemical profile such as reducing TG, TCH LDL, significantly reduced body weight gain,...
The oxidative stress of vessel endothelium is a major risk factor cardiovascular disorders. Antioxidative drugs are widely used in therapy. Aspirin eugenol ester (AEE) new pharmaceutical compound synthesized by esterification reaction aspirin with eugenols and possesses antioxidative activity. present study was designed to investigate the mechanism how AEE protects human umbilical vein endothelial cells (HUVECs) from H 2 O -induced stress. given HUVECs or without pretreatment. Changes...
Abstract Quality controlling for capsule endoscopic images can be completed with the assistance of artificial intelligence, but labeling process is time‐consuming. Domain adaption a robust tool cross‐domain learning to reach consistent target. Current research aims study feasibility and effectiveness domain from ordinary in quality controlling. Dynamic adversarial adaptation network (DAAN) was trained identify low‐quality using corresponding labels (source supervision) without (target so...
Aspirin eugenol ester (AEE) possesses anti-inflammatory and anti-oxidative effects. The study was conducted to evaluate the protective effect of AEE on paraquat-induced acute liver injury (ALI) in rats. against ALI by decreasing alanine transaminase aspartate levels blood, increasing superoxide dismutase, catalase, glutathione peroxidase levels, malondialdehyde blood liver. A total 32 metabolites were identified as biomarkers using metabolite analysis homogenate based ultra-performance...
Aspirin eugenol ester (AEE) is a new pharmaceutical compound esterified by aspirin and eugenol, which has anti‐inflammatory, antioxidant, other pharmacological activities. This study aimed at identifying the protective effect of AEE against H 2 O ‐induced apoptosis in rat adrenal pheochromocytoma PC12 cells possible mechanisms. The results cell viability assay showed that could increase stimulated , while alone had no significant on cells. Compared with control group, activities superoxide...