Bisphenol A (BPA) is widely distributed in the environment and human surroundings closely related to occurrence of many chronic diseases including female infertility. Although BPA-induced granulosa cell apoptosis has been reported, underlying mechanisms remain unknown. In this study, we evaluated induction effect BPA exposure on regulation KGN cells (a granulosa-like tumor line). Our results indicated that induced a dose- time-dependent manner. significantly promoted expression pro-apoptotic...

Scope While probiotics‐based therapies have exhibited potential in alleviating alcohol‐associated liver disease (ALD), the specific role of postbiotics derived from Lactobacillus reuteri ( L. ) ALD remains elusive. This study aims to investigate impact on ameliorating alcohol‐induced hepatic steatosis and underlying mechanisms. Methods results Using network pharmacology, elucidates targets pathways impacted by , identifying farnesoid X receptor (FXR) as a promising target for against ALD,...

Background and Purpose Aspirin eugenol ester (AEE) is a new drug compound synthesized by combining aspirin with eugenol. It was reported to possess anti‐thrombotic, anti‐atherosclerotic, anti‐oxidative effects. However, its molecular mechanism against oxidative injury unclear. This study investigated how AEE affected the of vascular endothelial cells in vivo vitro. Experimental Approach A hamster model atherosclerosis induced high fat diet (HFD) an vitro stress, H 2 O ‐induced apoptosis...

Long non-coding RNAs (lncRNAs) play a significant role in multiple human cancers as competing endogenous (ceRNAs). However, systematic mRNA-microRNA (miRNA)-lncRNA network linked to kidney renal clear cell carcinoma (KIRC) prognosis has not been described. In this study, we aimed identify the prognosis-related ceRNA regulatory and analyzed its relationship with immune infiltration predict KIRC patient survival. The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 related of was obtained through...

Inducible nitric oxide synthase (iNOS) and vascular endothelial dysfunction have been implicated in the development progression of atherosclerosis. This study aimed to elucidate role iNOS dysfunction. Ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with multivariate data analysis was used characterize metabolic changes human umbilical vein cells (HUVECs) response different treatment conditions. In addition, molecular biology techniques were...

Porcine epidemic diarrhea, a disastrous gastrointestinal disease, causes great financial losses due to its high infectivity, morbidity and mortality in suckling piglets despite the development application of various vaccines. In this study, high-throughput sequencing was used explore differences intestinal microbiota between uninfected infected with porcine diarrhea virus (PEDV). The results revealed that small PEDV showed low diversity dominated by Proteobacteria (49.1%). Additionally,...

Alcoholic liver disease (ALD), a type of chronic that is prevalent worldwide, still identified to have poor prognosis despite many medical treatment protocols. Thus, it urgent develop and test new protocols for ALD. Lactobacillus reuteri (L. reuteri) has been widely used in the clinical digestive system diseases, but studies on protective effect L. ALD are considered be rare. Therefore, present study, we examined provide data significant development An model established C57BL/6J mice treated...

Alcoholic liver disease (ALD) is caused by alcohol abuse and can progress to hepatitis, cirrhosis, even hepatocellular carcinoma. Previous studies suggested that Lactobacillus reuteri (L. reuteri) ameliorates ALD, but the exact mechanisms are not fully known. This study created an ALD model in mice, results showed L. significantly alleviating lipid accumulation mice. Transcriptome sequencing treatment group had most enriched metabolic pathway genes. We then studied farnesoid X receptor (FXR)...

The oxidative stress of vessel endothelium is a major risk factor cardiovascular disorders. Antioxidative drugs are widely used in therapy. Aspirin eugenol ester (AEE) new pharmaceutical compound synthesized by esterification reaction aspirin with eugenols and possesses antioxidative activity. present study was designed to investigate the mechanism how AEE protects human umbilical vein endothelial cells (HUVECs) from H 2 O -induced stress. given HUVECs or without pretreatment. Changes...

Species are facing strong selection pressures to adapt inhospitable high-altitude environments. Yaks a valuable species and an iconic symbol of the Qinghai-Tibet Plateau. Extensive studies adaptation have been conducted, but few focused on metabolism. In present study, we determined differences in serum metabolomics between yaks closely related low-altitude yellow cattle dairy cows. We generated high-quality metabolite profiling data for 36 samples derived from three species, clear...

The complex etiology, higher morbidity and mortality, poor prognosis, expensive cost of calf diarrhea have made it a catastrophic disease in the dairy industry. This study aims to assess biomarkers calves with predict related pathway. As subjects, nine healthy were enrolled, according strict enrollment criteria. serum metabolites detected by liquid chromatographic tandem mass spectrometry (LC-MS/MS), then analyzed online multivariate statistical analysis software further screen biomarkers....

Aspirin eugenol ester (AEE) possesses anti-thrombotic, anti-atherosclerotic and anti-oxidative effects. The study aims to clarify the mechanism underlying effects of AEE on vascular endothelial dysfunction. Both high-fat diet (HFD)-induced atherosclerotic rat model H2O2-induced human umbilical vein cells (HUVECs) were used investigate UPLC/QTOF-MS coupled with a multivariate data analysis method profile variations in metabolites HUVECs response different treatments. Pretreatment...

Aspirin eugenol ester (AEE) is a new potential drug with anti-inflammatory and antioxidant stress pharmacological activity. Paraquat (PQ) an effective commercially important herbicide that widely used worldwide. However, paraquat highly toxic can cause various complications acute organ damage, such as liver, kidney lung damage. The purpose of this study was to investigate whether AEE has protective effect on hepatotoxicity induced by PQ in vivo vitro. Cell viability, apoptosis rate,...

The purpose of this study is to investigate the protective effect γ-oryzanol (ORY) against hepatic ischemia reperfusion (HIR) injury and potential mechanisms ORY. ORY an important biologically active ingredient isolated from rice bran oil, which has anti-inflammatory antiapoptotic effects. However, it still unknown whether can protect liver HIR damage. In study, was administered orally for seven days, after animals were subjected 60 minutes reperfused 6 hours. Related indicators analyzed....

The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers clinical veterinarians in investigating the treatment schedule. This study aims to investigate RP dairy cows by plasma metabolomics. As subjects, 10 with healthy were enrolled according strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, deregulation total bilirubin (T-bil), alkaline phosphatase (ALP), reproductive hormones shown detecting biochemical...

Among digestive system cancers, the extremely poor prognosis of pancreatic cancer (PC) is a pressing concern. Nonoperative treatments such as targeted and immunotherapy, have improved current situation, however, accompanying side effects these chemicals should not be ignored. Here, we discovered novel hydroxycinnamic acid named sinapic (SA) derived from fruits, vegetables, cereals, oil crops an effective anti-PC molecule. Both in vitro vivo models designed showed that SA exhibited anticancer...

Metabolic abnormality has been considered to be the seventh characteristic in cancer cells. The potential prospect of using serum biomarkers metabolites differentiate ALL from AML remains unclear. purpose our study is probe whether differences metabolomics are related clinical laboratory-related indicators. We used LC-MS-based analysis 50 peripheral blood samples leukemia patients a single center. Then Chi-square test and T were analyze characteristics, laboratory indicators cytokines with...